Anticancer effects of zoledronic acid against human osteosarcoma cells

2006 ◽  
Vol 24 (6) ◽  
pp. 1145-1152 ◽  
Author(s):  
B. Kubista ◽  
K. Trieb ◽  
F. Sevelda ◽  
C. Toma ◽  
F. Arrich ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Human Osteosarcoma Cells

scholarly journals The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1

2018 ◽  
Vol 19 (7) ◽  
pp. 1909 ◽  
Author(s):  
Felipe Lima ◽  
Viviane Seba ◽  
Gabriel Silva ◽  
Guilherme Torrezan ◽  
Carlos Polaquini ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Osteosarcoma Cells ◽  
Curcumin Analog ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Human Osteosarcoma Cells

Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells

2014 ◽  
Vol 22 (1) ◽  
pp. 66-72 ◽  
Author(s):  
Antonietta Rizzo ◽  
Gabriella Misso ◽  
Nazario Bevilacqua ◽  
Giovanna Donnarumma ◽  
Angela Lombardi ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Chlamydia Pneumoniae ◽  
Cytokine Production ◽  
Osteosarcoma Cells ◽  
Cytotoxic Effects ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

scholarly journals Ginsenoside Rg1 Drives Stimulations of Timosaponin AIII-Induced Anticancer Effects in Human Osteosarcoma Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Sang Yeol Lee
Keyword(s):  
Cell Migration ◽  
Ginsenoside Rg1 ◽  
Osteosarcoma Cells ◽  
Human Organ ◽  
Human Osteosarcoma ◽  
Anticancer Effects ◽  
Organ Systems ◽  
Human Osteosarcoma Cells ◽  
Mg63 Cells ◽  
Timosaponin Aiii

A ginsenoside Rg1 is an active compound extracted from the stem and/or root of ginseng. Rg1 has been known to affect various human organ systems including the immune, cardiovascular, and nervous systems with its pharmacological effects. Timosaponin AIII (TA3) is a type of spirostanol saponins that are the major compounds of Anemarrhena asphodeloides. TA3 exerts anticancer effects in various human cancers, and the effects include attenuations of cancer cell migration and induction of apoptosis. In this study, I report that Rg1 drives the stimulation of TA3-induced cytotoxic effects in MG63 human osteosarcoma cells. Rg1 stimulates TA3-induced apoptosis in MG63 cells via selective intensification of caspase-3 activation. Rg1 and TA3 synergistically induced antimetastatic effects such as attenuation of MG63 cell migration and inhibitions of matrix metalloproteinases (MMP-2 and MMP-9). Rg1 and TA3 synergistically suppressed JNK, p38, ERK, β-catenin, and CREB signaling, which are key regulators of cancer metastasis. Finally, the synergistic anticancer effects of Rg1 and TA3 were also observed in U2OS human osteosarcoma cells, and this may indicate that the synergy is not limited specifically to MG63 cells. The results presented here suggest that the combinatorial use of Rg1 and TA3 may be a promising way to develop an effective antiosteosarcoma agent.

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