scholarly journals FGF Family: From Drug Development to Clinical Application

2018 ◽  
Vol 19 (7) ◽  
pp. 1875 ◽  
Author(s):  
Qi Hui ◽  
Zi Jin ◽  
Xiaokun Li ◽  
Changxiao Liu ◽  
Xiaojie Wang
Keyword(s):  
Drug Development ◽  
Clinical Application

Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy

Nanoscale ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 611-621 ◽  
Author(s):  
Ya Chang ◽  
Shuo Yao ◽  
Yifang Chen ◽  
Jingjing Huang ◽  
Aihua Wu ◽  
...  
Keyword(s):  
Drug Development ◽  
Clinical Application ◽  
Tumor Targeting ◽  
Genetically Engineered ◽  
Ribosome Inactivating Proteins

A SHEATH strategy was developed to overcome the delivery barrier against drug development and the clinical application of the cytoplasmic active proteins (e.g., ribosome-inactivating proteins, RIPs).

scholarly journals Synthetic derivatives of genistein, their properties and possible applications.

2010 ◽  
Vol 57 (1) ◽  
Author(s):  
Aleksandra Rusin ◽  
Zdzisław Krawczyk ◽  
Grzegorz Grynkiewicz ◽  
Agnieszka Gogler ◽  
Jadwiga Zawisza-Puchałka ◽  
...  
Keyword(s):  
Drug Development ◽  
Physicochemical Properties ◽  
Clinical Application ◽  
Current Knowledge ◽  
Chemical Reactivity ◽  
Food Supplement ◽  
Basic Information ◽  
Chemopreventive Agent ◽  
Synthetic Derivatives ◽  
Derivatives Of

Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.

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