Genetically-engineered protein prodrug-like nanoconjugates for tumor-targeting biomimetic delivery via a SHEATH strategy

Nanoscale ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 611-621 ◽  
Author(s):  
Ya Chang ◽  
Shuo Yao ◽  
Yifang Chen ◽  
Jingjing Huang ◽  
Aihua Wu ◽  
...  
Keyword(s):  
Drug Development ◽  
Clinical Application ◽  
Tumor Targeting ◽  
Genetically Engineered ◽  
Ribosome Inactivating Proteins

A SHEATH strategy was developed to overcome the delivery barrier against drug development and the clinical application of the cytoplasmic active proteins (e.g., ribosome-inactivating proteins, RIPs).

scholarly journals Tumor-Targeting Bacteria: As Vectors, Immunotherapeutic Agents And Tumor-Targeting Probes For Cancer Detection And Therapy

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Lihini Ranesha Weerakkody ◽  
Сhamindri Witharana
Keyword(s):  
Anticancer Agents ◽  
Tumor Targeting ◽  
Bacterial Species ◽  
Bifidobacterium Longum ◽  
Anticancer Therapy ◽  
Genetically Engineered ◽  
Treatment Modalities ◽  
Bacterial Strains ◽  
Angiogenic Proteins

Cancer is the world's second leading cause of death in humans. Conventional anticancer therapies are often associated with lack of tumor specificity, failure to detect small metastases, increased resistance of tumors to anticancer drugs, and unintended adverse effects. Numerous alternative and better strategies in cancer treatment have been developed to overcome the negative effects of traditional cancer therapies. More than a century ago, William Coley, the father of cancer immounotherapy, laid the groundwork for bacterial anticancer therapy. Bacterial immunotherapy has been emerging as a potential anticancer therapy. Moreover, certain obligate and facultative anaerobic bacterial species are exploited as vectors for gene delivery to treat cancer. These genes encode for anticancer agents, cytokines, cytotoxic peptides, anti-angiogenic proteins, therapeutic molecules and prodrug-converting enzymes. Genetically engineered bacterial strains of Salmonella, Bifidobacterium, Clostridium and Listeria are widely used to deliver genes in anticancer therapy since they can selectively accumulate in solid tumors with a hypoxic/necrotic core in vivo, providing appealing delivery systems to target therapeutic agents and immunomodulatory molecules to the site of tumor. Certain genetically modified bacterial species such as Bifidobacterium longum and Bacillus licheniformis have been effectively used for the enzyme/prodrug therapy for cancer. Furthermore, certain anaerobic bacteria are emerging as potential tumor markers due to the increased mobility and the selectivity in germinating and multiplying in hypoxic/anoxic environments. Many of these novel developments have been studied extensively in different experimental models of cancer and certain clinical trials are ongoing for some treatment modalities. Although favourable results have shown so far, further studies and technological innovations are required to ensure the efficacy of bacterial anticancer therapy.

scholarly journals Synthetic derivatives of genistein, their properties and possible applications.

2010 ◽  
Vol 57 (1) ◽  
Author(s):  
Aleksandra Rusin ◽  
Zdzisław Krawczyk ◽  
Grzegorz Grynkiewicz ◽  
Agnieszka Gogler ◽  
Jadwiga Zawisza-Puchałka ◽  
...  
Keyword(s):  
Drug Development ◽  
Physicochemical Properties ◽  
Clinical Application ◽  
Current Knowledge ◽  
Chemical Reactivity ◽  
Food Supplement ◽  
Basic Information ◽  
Chemopreventive Agent ◽  
Synthetic Derivatives ◽  
Derivatives Of

Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.

Metal-free semi-aromatic polyester as nanodrug carrier: A novel tumor targeting drug delivery vehicle for potential clinical application

2020 ◽  
Vol 107 ◽  
pp. 110285 ◽  
Author(s):  
Piyush Kumar Gupta ◽  
Surya Kant Tripathi ◽  
Sreenath Pappuru ◽  
Siva Chander Chabattula ◽  
Kavitha Govarthanan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Application ◽  
Tumor Targeting ◽  
Delivery Vehicle ◽  
Metal Free ◽  
Drug Delivery Vehicle ◽  
Potential Clinical Application ◽  
Aromatic Polyester

scholarly journals FGF Family: From Drug Development to Clinical Application

2018 ◽  
Vol 19 (7) ◽  
pp. 1875 ◽  
Author(s):  
Qi Hui ◽  
Zi Jin ◽  
Xiaokun Li ◽  
Changxiao Liu ◽  
Xiaojie Wang
Keyword(s):  
Drug Development ◽  
Clinical Application

ANALYSES OF DIFFERENT GENETICALLY ENGINEERED IMMUNOGLOBULIN FORMS FOR TUMOR TARGETING AND THERAPY

1994 ◽  
Vol 16 (2) ◽  
pp. 163
Author(s):  
J. Schlom ◽  
P. Hand ◽  
D. Slavin-Chiorini ◽  
J. Greiner ◽  
P. Schott ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Genetically Engineered
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