scholarly journals Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine

2018 ◽  
Vol 19 (3) ◽  
pp. 754 ◽  
Author(s):  
Hainan Sun ◽  
Jianbo Jia ◽  
Cuijuan Jiang ◽  
Shumei Zhai
Keyword(s):  
Cell Death ◽  
Gold Nanoparticle ◽  
Potential Applications

scholarly journals Characterization of Cell Lysis in Pseudomonas putida Induced upon Expression of Heterologous Killing Genes

1998 ◽  
Vol 64 (12) ◽  
pp. 4904-4911 ◽  
Author(s):  
M. Carmen Ronchel ◽  
Lázaro Molina ◽  
Angela Witte ◽  
Werner Lutbiz ◽  
Søren Molin ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Cell Death ◽  
Pseudomonas Putida ◽  
Membrane Permeability ◽  
Cell Lysis ◽  
Physiological Effects ◽  
Extracellular Medium ◽  
Biological Containment ◽  
Potential Applications

ABSTRACT Active biological containment systems are based on the controlled expression of killing genes. These systems are of interest for thePseudomonadaceae because of the potential applications of these microbes as bioremediation agents and biopesticides. The physiological effects that lead to cell death upon the induction of expression of two different heterologous killing genes in nonpathogenicPseudomonas putida KT2440 derivatives have been analyzed.P. putida CMC4 and CMC12 carry in their chromosomes a fusion of the PA1-04/03 promoter to the Escherichia coli gef gene and the φX174 lysis gene E, respectively. Expression of the killing genes is controlled by the LacI protein, whose expression is initiated from the XylS-dependent Pm promoter. Under induced conditions, killing of P. putidaCMC12 cells mediated by φX174 lysis protein E was faster than that observed for P. putida CMC4, for which the Gef protein was the killing agent. In both cases, cell death occurred as a result of impaired respiration, altered membrane permeability, and the release of some cytoplasmic contents to the extracellular medium.

scholarly journals Novel fluorinated ligands for gold nanoparticle labelling with applications in 19F-MRI

2017 ◽  
Vol 53 (16) ◽  
pp. 2447-2450 ◽  
Author(s):  
Olatz Michelena ◽  
Daniel Padro ◽  
Carolina Carrillo-Carrión ◽  
Pablo del Pino ◽  
Jorge Blanco ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Fluorinated Ligands ◽  
19F Mri ◽  
Potential Applications

Novel fluorinated ligands for gold nanoparticle labelling and with potential applications in 19F-MRI have been designed and synthesised.

scholarly journals Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Mengke Niu ◽  
Ming Yi ◽  
Ning Li ◽  
Suxia Luo ◽  
Kongming Wu
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Gene Mutations ◽  
Predictive Biomarkers ◽  
Tumor Infiltrating Lymphocytes ◽  
Driver Gene ◽  
Laboratory Findings ◽  
Mutation Burden ◽  
Potential Applications ◽  
Nsclc Patients

AbstractImmunotherapy, especially anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) treatment has significantly improved the survival of non-small cell lung cancer (NSCLC) patients. However, the overall response rate remains unsatisfactory. Many factors affect the outcome of anti-PD-1/PD-L1 treatment, such as PD-L1 expression level, tumor-infiltrating lymphocytes (TILs), tumor mutation burden (TMB), neoantigens, and driver gene mutations. Further exploration of biomarkers would be favorable for the best selection of patients and precisely predict the efficacy of anti-PD-1/PD-L1 treatment. In this review, we summarized the latest advances in this field, and discussed the potential applications of these laboratory findings in the clinic.

scholarly journals Cell death via remote heating of microparticles with potential applications in atherosclerosis and thrombosis therapy

2015 ◽  
Author(s):  
Angelo Gaitas ◽  
Gwangseong Kim
Keyword(s):  
Cell Death ◽  
Induction Heating ◽  
Initial Density ◽  
Spherical Particles ◽  
Maximum Temperature ◽  
Inductive Heating ◽  
Iron Particles ◽  
Heating Treatment ◽  
Potential Applications ◽  
Micrometer Size

We report a method to cause cell death by remotely heating microparticles by induction heating, this technique could be used to remove vascular deposits and thrombosis. In this preliminary work, we used micrometer size spherical (ferromagnetic) particles and (pure) iron particles to heat remotely macrophages using inductive heating. Iron particles achieved maximum temperatures of 51 ± 0.5 oC after 30 minutes of inductive heating, while spherical particles achieved a maximum temperature of 43.9 ± 0.2 oC (N=6). The therapeutic outcome was determined by monitoring cell re-growth for 2 days following inductive heating treatment. The initial density of cells in the first day prior to induction heating was 105,000 ± 20,820 cells/ml (N=3). 24 hours after induction heating this number was reduced to 6,666 ± 4,410 cells/ml for the spherical particles and 16,666 ± 9,280 cells/ml for the iron particles. The second day the cells grew to 26,667 ± 6,670 cells/ml and 30,000 ± 15,280 cells/ml respectively. Compared to cell cultures with iron and spherical particles that were not subjected to induction heating, we observed a 97% reduction in cell count for the spherical particles and a 91% reduction for the iron particles after the first 24 hours. After 48 hours we observed a 95% reduction in cell growth for both spherical and iron particles. Induction heating of microparticles was highly effective in reducing the macrophage population and preventing their growth.

scholarly journals Gold nanoparticle-doped silk film as biocompatible SERS substrate

RSC Advances ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 1937-1942 ◽  
Author(s):  
Chengchen Guo ◽  
Genevieve N. Hall ◽  
John B. Addison ◽  
Jeffery L. Yarger
Keyword(s):  
Gold Nanoparticle ◽  
Rapid Method ◽  
Biomedical Research ◽  
Sers Substrate ◽  
Potential Applications ◽  
Silk Films ◽  
Silk Film

In this work, we present a novel rapid method for fabricating biocompatible, biodegradable gold nanoparticle-embedded silk films (AuNP–silk films) that have potential applications in bioengineering and biomedical research.

Single Molecular Magnet - Gold Nanoparticle Composites

2009 ◽  
Vol 1198 ◽  
Author(s):  
Gopalan Balaji ◽  
Gudrun Bovenkamp ◽  
Vadim Palshin ◽  
Challa Kumar
Keyword(s):  
Gold Nanoparticle ◽  
Data Storage ◽  
Single Molecule ◽  
Composite Structures ◽  
Blocking Temperature ◽  
Molecular Magnet ◽  
Transition Elements ◽  
Single Molecule Magnets ◽  
Potential Applications ◽  
Ultrahigh Density

AbstractThe past decade has witnessed a great interest in single molecule magnets (SMM) especially those based on manganese such as Mn12-acetate due to their potential applications in ultrahigh density data storage and quantum computing devices. The focus so far has been in finding different derivatives of Mn or other complexes based on transition elements in order to raise the blocking temperature of single-molecule magnets (SMMs). Herein we propose a fundamentally new approach of generating new category of SMMs through formation of composite structures by binding SMMs on to nanoparticles. In this report, we present the synthesis and characterization of single molecular magnet - gold nanoparticle composite- Mn12-cysteinate functionalized gold nanoparticles.

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