SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma

Minori Tsuge; Mitsuhiko Osaki; Ryo Sasaki; Mio Hirahata; Futoshi Okada

doi:10.3390/ijms19030736

SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma

International Journal of Molecular Sciences ◽

10.3390/ijms19030736 ◽

2018 ◽

Vol 19 (3) ◽

pp. 736 ◽

Cited By ~ 1

Author(s):

Minori Tsuge ◽

Mitsuhiko Osaki ◽

Ryo Sasaki ◽

Mio Hirahata ◽

Futoshi Okada

Keyword(s):

Plasminogen Activator ◽

Lung Metastasis ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Human Osteosarcoma ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Faculty Opinions recommendation of Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019931.226492 ◽

2004 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A Novel Antithrombotic Role for High Molecular Weight Kininogen as Inhibitor of Plasminogen Activator Inhibitor-1 Function

Journal of Biological Chemistry ◽

10.1074/jbc.m204010200 ◽

2002 ◽

Vol 277 (36) ◽

pp. 32677-32682 ◽

Cited By ~ 14

Author(s):

Triantafyllos Chavakis ◽

Robin A. Pixley ◽

Irma Isordia-Salas ◽

Robert W. Colman ◽

Klaus T. Preissner

Keyword(s):

Molecular Weight ◽

High Molecular Weight ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

High Molecular Weight Kininogen ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A novel inhibitor of plasminogen activator inhibitor-1, T-686, modulates development of atherosclerosis in vivo in rabbits

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(96)80451-7 ◽

1996 ◽

Vol 27 (2) ◽

pp. 64 ◽

Cited By ~ 1

Author(s):

Boris Vinogradsky ◽

Stephen P. Bell ◽

Hitoshi Okada ◽

Amy S. Guala ◽

Dagnija Thornton ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Expert Opinion on Therapeutic Targets ◽

10.1517/14728222.12.11.1313 ◽

2008 ◽

Vol 12 (11) ◽

pp. 1313-1320 ◽

Cited By ~ 11

Author(s):

Jun-ichi Suzuki ◽

Masahito Ogawa ◽

Susumu Muto ◽

Akiko Itai ◽

Mitsuaki Isobe

Keyword(s):

Plasminogen Activator ◽

Specific Inhibitor ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Autoimmune Myocarditis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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PAI-039, An Inhibitor Of Plasminogen Activator Inhibitor-1, Ameliorates Lung Injury Induced By Bleomycin

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3706 ◽

2012 ◽

Author(s):

Jie Liu ◽

Xun Wang ◽

Qin Wang ◽

Chunxue Bai ◽

Yuanlin Song

Keyword(s):

Lung Injury ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization

Journal of Medicinal Chemistry ◽

10.1021/jm049766q ◽

2004 ◽

Vol 47 (14) ◽

pp. 3491-3494 ◽

Cited By ~ 93

Author(s):

Hassan Elokdah ◽

Magid Abou-Gharbia ◽

James K. Hennan ◽

Geraldine McFarlane ◽

Cheryl P. Mugford ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Synthesis of a conformationally constrained threonine–valine dipeptide mimetic: design of a potential inhibitor of plasminogen activator inhibitor-1

Tetrahedron Letters ◽

10.1016/s0040-4039(01)02080-9 ◽

2002 ◽

Vol 43 (1) ◽

pp. 41-43 ◽

Cited By ~ 10

Author(s):

Peter R Guzzo ◽

Michael P Trova ◽

Tord Inghardt ◽

Marcel Linschoten

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Conformationally Constrained ◽

Potential Inhibitor ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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SPECIFIC INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 ATTENUATES MYOCARDIAL CELL INFILTRATION AND GRAFT ARTERIAL DISEASES IN MURINE CARDIAC ALLOGRAFTS

Transplantation Journal ◽

10.1097/01.tp.0000332413.98060.c3 ◽

2008 ◽

Vol 86 (Supplement) ◽

pp. 110

Author(s):

J-I Suzuki ◽

M Ogawa ◽

S Muto ◽

Y Yamaguchi ◽

A Itai ◽

...

Keyword(s):

Plasminogen Activator ◽

Specific Inhibitor ◽

Plasminogen Activator Inhibitor ◽

Myocardial Cell ◽

Cell Infiltration ◽

Plasminogen Activator Inhibitor 1 ◽

Cardiac Allografts ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Epigallocatechin-3-gallate (EGCG) Serves as a Novel Scaffold for Designing an Inhibitor of Plasminogen Activator Inhibitor-1 (PAI-1)

Bulletin of the Korean Chemical Society ◽

10.1002/bkcs.11188 ◽

2017 ◽

Vol 38 (8) ◽

pp. 964-967

Author(s):

Kwang-Su Park ◽

Mi Kyoung Kim ◽

Yoon Kyung Choi ◽

Youhoon Chong

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Novel Scaffold ◽

Activator Inhibitor ◽

Pai 1 ◽

Inhibitor Of Plasminogen Activator

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SK-216, an Inhibitor of Plasminogen Activator Inhibitor-1, Limits Tumor Progression and Angiogenesis

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-13-0041 ◽

2013 ◽

Vol 12 (11) ◽

pp. 2378-2388 ◽

Cited By ~ 31

Author(s):

Takeshi Masuda ◽

Noboru Hattori ◽

Tadashi Senoo ◽

Shin Akita ◽

Nobuhisa Ishikawa ◽

...

Keyword(s):

Tumor Progression ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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