Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1:  Design, Synthesis, and Preclinical Characterization

Hassan Elokdah; Magid Abou-Gharbia; James K. Hennan; Geraldine McFarlane; Cheryl P. Mugford; Girija Krishnamurthy; David L. Crandall

doi:10.1021/jm049766q

Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization

Journal of Medicinal Chemistry ◽

10.1021/jm049766q ◽

2004 ◽

Vol 47 (14) ◽

pp. 3491-3494 ◽

Cited By ~ 93

Author(s):

Hassan Elokdah ◽

Magid Abou-Gharbia ◽

James K. Hennan ◽

Geraldine McFarlane ◽

Cheryl P. Mugford ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Faculty Opinions recommendation of Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019931.226492 ◽

2004 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization.

ChemInform ◽

10.1002/chin.200442134 ◽

2004 ◽

Vol 35 (42) ◽

Author(s):

Hassan Elokdah ◽

Magid Abou-Gharbia ◽

James K. Hennan ◽

Geraldine McFarlane ◽

Cheryl P. Mugford ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.10.067 ◽

2008 ◽

Vol 18 (24) ◽

pp. 6419-6422 ◽

Cited By ~ 9

Author(s):

Hiroshi Miyazaki ◽

Tsuyoshi Ogiku ◽

Hiroshi Sai ◽

Hiroshi Ohmizu ◽

Jun Murakami ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Orally Active ◽

Activator Inhibitor ◽

Pai 1

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A Novel Antithrombotic Role for High Molecular Weight Kininogen as Inhibitor of Plasminogen Activator Inhibitor-1 Function

Journal of Biological Chemistry ◽

10.1074/jbc.m204010200 ◽

2002 ◽

Vol 277 (36) ◽

pp. 32677-32682 ◽

Cited By ~ 14

Author(s):

Triantafyllos Chavakis ◽

Robin A. Pixley ◽

Irma Isordia-Salas ◽

Robert W. Colman ◽

Klaus T. Preissner

Keyword(s):

Molecular Weight ◽

High Molecular Weight ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

High Molecular Weight Kininogen ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A novel inhibitor of plasminogen activator inhibitor-1, T-686, modulates development of atherosclerosis in vivo in rabbits

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(96)80451-7 ◽

1996 ◽

Vol 27 (2) ◽

pp. 64 ◽

Cited By ~ 1

Author(s):

Boris Vinogradsky ◽

Stephen P. Bell ◽

Hitoshi Okada ◽

Amy S. Guala ◽

Dagnija Thornton ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis

Expert Opinion on Therapeutic Targets ◽

10.1517/14728222.12.11.1313 ◽

2008 ◽

Vol 12 (11) ◽

pp. 1313-1320 ◽

Cited By ~ 11

Author(s):

Jun-ichi Suzuki ◽

Masahito Ogawa ◽

Susumu Muto ◽

Akiko Itai ◽

Mitsuaki Isobe

Keyword(s):

Plasminogen Activator ◽

Specific Inhibitor ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Autoimmune Myocarditis ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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PAI-039, An Inhibitor Of Plasminogen Activator Inhibitor-1, Ameliorates Lung Injury Induced By Bleomycin

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3706 ◽

2012 ◽

Author(s):

Jie Liu ◽

Xun Wang ◽

Qin Wang ◽

Chunxue Bai ◽

Yuanlin Song

Keyword(s):

Lung Injury ◽

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Synthesis of a conformationally constrained threonine–valine dipeptide mimetic: design of a potential inhibitor of plasminogen activator inhibitor-1

Tetrahedron Letters ◽

10.1016/s0040-4039(01)02080-9 ◽

2002 ◽

Vol 43 (1) ◽

pp. 41-43 ◽

Cited By ~ 10

Author(s):

Peter R Guzzo ◽

Michael P Trova ◽

Tord Inghardt ◽

Marcel Linschoten

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Conformationally Constrained ◽

Potential Inhibitor ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.03.045 ◽

2014 ◽

Vol 24 (10) ◽

pp. 2379-2382 ◽

Cited By ~ 7

Author(s):

Fanglei Chen ◽

Guiping Zhang ◽

Zebin Hong ◽

Zhonghui Lin ◽

Min Lei ◽

...

Keyword(s):

Plasminogen Activator ◽

Plasminogen Activator Inhibitor ◽

Plasminogen Activator Inhibitor 1 ◽

Design Synthesis ◽

Activator Inhibitor ◽

Pai 1

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SPECIFIC INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 ATTENUATES MYOCARDIAL CELL INFILTRATION AND GRAFT ARTERIAL DISEASES IN MURINE CARDIAC ALLOGRAFTS

Transplantation Journal ◽

10.1097/01.tp.0000332413.98060.c3 ◽

2008 ◽

Vol 86 (Supplement) ◽

pp. 110

Author(s):

J-I Suzuki ◽

M Ogawa ◽

S Muto ◽

Y Yamaguchi ◽

A Itai ◽

...

Keyword(s):

Plasminogen Activator ◽

Specific Inhibitor ◽

Plasminogen Activator Inhibitor ◽

Myocardial Cell ◽

Cell Infiltration ◽

Plasminogen Activator Inhibitor 1 ◽

Cardiac Allografts ◽

Activator Inhibitor ◽

Inhibitor Of Plasminogen Activator

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