scholarly journals A Case-Control Study of the Genetic Variability in Reactive Oxygen Species—Metabolizing Enzymes in Melanoma Risk

2018 ◽  
Vol 19 (1) ◽  
pp. 242 ◽  
Author(s):  
Tze-An Yuan ◽  
Vandy Yourk ◽  
Ali Farhat ◽  
Argyrios Ziogas ◽  
Frank Meyskens ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Genetic Variability ◽  
Case Control Study ◽  
Reactive Oxygen ◽  
Case Control ◽  
Oxygen Species ◽  
Melanoma Risk ◽  
Metabolizing Enzymes ◽  
Control Study

Reactive oxygen species and gastric cancer risk: a large nested case–control study in Japan

2015 ◽  
Vol 30 (7) ◽  
pp. 589-594 ◽  
Author(s):  
Enbo Ma ◽  
Shizuka Sasazuki ◽  
Taichi Shimazu ◽  
Norie Sawada ◽  
Taiki Yamaji ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Risk ◽  
Case Control Study ◽  
Reactive Oxygen ◽  
Case Control ◽  
Oxygen Species ◽  
Gastric Cancer Risk ◽  
Nested Case Control ◽  
Control Study

scholarly journals CAT, GPX1, MnSOD, GSTM1, GSTT1, andGSTP1Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Claudia Bănescu ◽  
Adrian P. Trifa ◽  
Septimiu Voidăzan ◽  
Valeriu G. Moldovan ◽  
Ioan Macarie ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Polymorphisms ◽  
Myeloid Leukemia ◽  
Case Control Study ◽  
Case Control ◽  
Oxygen Species ◽  
Heterozygous Genotype ◽  
Variant Genotype ◽  
Homozygous Variant Genotype ◽  
Control Study

Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships betweenCATC262T,GPX1Pro198Leu,MnSODAla16Val,GSTM1, GSTT1, andGSTP1Ile105Val polymorphisms and the risk of CML. No association was observed between CML and variant genotypes ofGPX1, MnSOD, GSTM1, andGSTT1polymorphisms in any of the investigated cases. Our study suggests that the homozygous variant genotype of theGSTP1Ile105Val gene polymorphisms may be associated with the risk of developing CML (OR=2.5; 95% CI=1.08–5.7;Pvalue = 0.02), while the heterozygous genotype of theCATC262T polymorphism seems to have a protective effect against CML (OR=0.59, 95% CI=0.39–0.89,Pvalue = 0.01). In most cases, no association was found between laboratory parameters and prognostic factors and the variant genotype of investigated gene polymorphisms. We concluded thatCAT, GPX, MnSOD, GSTM1, andGSTT1gene polymorphisms are not associated with the risk of CML. Variant genotype of theGSTP1Ile105Val gene polymorphisms may contribute to the risk of developing CML.

scholarly journals Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: A case-control study

2008 ◽  
Vol 122 (9) ◽  
pp. 2077-2084 ◽  
Author(s):  
Chunying Li ◽  
Zhensheng Liu ◽  
Li E. Wang ◽  
Jeffrey E. Gershenwald ◽  
Jeffrey E. Lee ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Vdr Gene ◽  
Control Study

scholarly journals Melanocytic Nevi, Nevus Genes, and Melanoma Risk in a Large Case-Control Study in the United Kingdom

2010 ◽  
Vol 19 (8) ◽  
pp. 2043-2054 ◽  
Author(s):  
Julia A. Newton-Bishop ◽  
Yu-Mei Chang ◽  
Mark M. Iles ◽  
John C. Taylor ◽  
Bert Bakker ◽  
...  
Keyword(s):  
United Kingdom ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Melanocytic Nevi ◽  
The United Kingdom ◽  
Control Study ◽  
Large Case

scholarly journals Melanoma risk in association with serum leptin levels and lifestyle parameters: a case–control study

2008 ◽  
Vol 19 (2) ◽  
pp. 384-389 ◽  
Author(s):  
H. Gogas ◽  
M. Trakatelli ◽  
N. Dessypris ◽  
A. Terzidis ◽  
A. Katsambas ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Serum Leptin ◽  
Control Study

Relationship between sunbed use and melanoma risk in a large case-control study in the United Kingdom

2011 ◽  
Vol 130 (12) ◽  
pp. 3011-3013 ◽  
Author(s):  
Faye Elliott ◽  
Mariano Suppa ◽  
May Chan ◽  
Susan Leake ◽  
Birute Karpavicius ◽  
...  
Keyword(s):  
United Kingdom ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
The United Kingdom ◽  
Sunbed Use ◽  
Control Study ◽  
Large Case

Contribution of melanocortin-1 receptor gene variants to sporadic cutaneous melanoma risk in a population in central Italy: a case???control study

2006 ◽  
Vol 16 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Maria Concetta Fargnoli ◽  
Emma Altobelli ◽  
Gisela Keller ◽  
Sergio Chimenti ◽  
Heinz H??fler ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Receptor Gene ◽  
Central Italy ◽  
Case Control ◽  
Gene Variants ◽  
Melanoma Risk ◽  
Melanocortin 1 Receptor ◽  
Control Study

scholarly journals Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case–control study

2017 ◽  
Vol 117 (3) ◽  
pp. 432-438 ◽  
Author(s):  
Marcella Malavolti ◽  
Carlotta Malagoli ◽  
Catherine M. Crespi ◽  
Furio Brighenti ◽  
Claudia Agnoli ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Population Based ◽  
Glycaemic Index ◽  
Case Control ◽  
Melanoma Risk ◽  
Glycaemic Load ◽  
Increased Risk ◽  
Incident Cases ◽  
Control Study

AbstractGlycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case–control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2·38; 95 % CI 1·25, 4·52 for the highest v. the lowest quintile of GL score, Pfor trend 0·070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

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