scholarly journals Silk Fibroin-Alginate-Hydroxyapatite Composite Particles in Bone Tissue Engineering Applications In Vivo

2017 ◽  
Vol 18 (4) ◽  
pp. 858 ◽  
Author(s):  
You-Young Jo ◽  
Seong-Gon Kim ◽  
Kwang-Jun Kwon ◽  
HaeYong Kweon ◽  
Weon-Sik Chae ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Composite Particles ◽  
Engineering Applications ◽  
Hydroxyapatite Composite

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

Enhancing bioactive properties of silk fibroin with diatom particles for bone tissue engineering applications

2017 ◽  
Vol 12 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Thi Duy Hanh Le ◽  
Volha Liaudanskaya ◽  
Walter Bonani ◽  
Claudio Migliaresi ◽  
Antonella Motta
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Engineering Applications ◽  
Bioactive Properties

Comparisons between gelatin-tussah silk fibroin/hydroxyapatite and gelatin-Bombyx mori silk fibroin/hydroxyapatite nano-composites for bone tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (93) ◽  
pp. 76526-76537 ◽  
Author(s):  
Jiabing Ran ◽  
Jingxiao Hu ◽  
Guanglin Sun ◽  
Si Chen ◽  
Li Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bombyx Mori ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Nano Composites ◽  
Enhancement Mechanism ◽  
Hydroxyapatite Composite ◽  
Bombyx Mori Silk ◽  
Tussah Silk Fibroin

Enhancement mechanism of tussah silk fibroin to gelatin-tussah silk fibroin/hydroxyapatite composite.

scholarly journals In vitro study of novel microparticle based silk fibroin scaffold with osteoblast-like cells for load-bearing osteo-regenerative applications

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26551-26558 ◽  
Author(s):  
Nimisha Parekh ◽  
Chandni Hushye ◽  
Saniya Warunkar ◽  
Sayam Sen Gupta ◽  
Anuya Nisal
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
In Vitro Study ◽  
Vitro Study ◽  
Engineering Applications ◽  
Load Bearing ◽  
Silk Fibroin Scaffold

Silk Fibroin microparticle scaffolds show promise in bone tissue engineering applications.

scholarly journals In vitro and in vivo Biocompatibility of Alginate Dialdehyde/Gelatin Hydrogels with and without Nanoscaled Bioactive Glass for Bone Tissue Engineering Applications

Materials ◽  
2014 ◽  
Vol 7 (3) ◽  
pp. 1957-1974 ◽  
Author(s):  
Ulrike Rottensteiner ◽  
Bapi Sarker ◽  
Dominik Heusinger ◽  
Diana Dafinova ◽  
Subha Rath ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

scholarly journals In vivo engineering of a human vasculature for bone tissue engineering applications

2008 ◽  
Vol 13 (9b) ◽  
pp. 3380-3386 ◽  
Author(s):  
Lilian Steffens ◽  
Andreas Wenger ◽  
G. Björn Stark ◽  
Günter Finkenzeller
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications

scholarly journals Plant-derived Cellulose Scaffolds for Bone Tissue Engineering

2020 ◽  
Author(s):  
Maxime Leblanc Latour ◽  
Maryam Tarar ◽  
Ryan J. Hickey ◽  
Charles M. Cuerrier ◽  
Isabelle Catelas ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Pore Size ◽  
Bone Tissue ◽  
Structural Features ◽  
Osteogenic Potential ◽  
Engineering Applications ◽  
Alizarin Red

AbstractPlant-derived cellulose biomaterials have recently been utilized in several tissue engineering applications. Naturally-derived cellulose scaffolds have been shown to be highly biocompatible in vivo, possess structural features of relevance to several tissues, as well as support mammalian cell invasion and proliferation. Recent work utilizing decellularized apple hypanthium tissue has shown that it possesses a pore size and properties similar to trabecular bone. In the present study, we examined the potential of apple-derived cellulose scaffolds for bone tissue engineering (BTE). Confocal microscopy revealed that the scaffolds had a suitable pore size for BTE applications. To analyze their in vitro mineralization potential, MC3T3-E1 pre-osteoblasts were seeded in either bare cellulose scaffolds or in composite scaffolds composed of cellulose and collagen I. Following chemically-induced differentiation, scaffolds were mechanically tested and evaluated for mineralization. The Young’s modulus of both types of scaffolds significantly increased after cell differentiation. Alkaline phosphatase and Alizarin Red staining further highlighted the osteogenic potential of the scaffolds. Histological sectioning of the constructs revealed complete invasion by the cells and mineralization throughout the entire constructs. Finally, scanning electron microscopy demonstrated the presence of mineral aggregates deposited on the scaffolds after differentiation, and energy-dispersive spectroscopy confirmed the presence of phosphate and calcium. In summary, our results indicate that plant-derived cellulose is a promising scaffold candidate for bone tissue engineering applications.

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