scholarly journals Liver Effects of Clinical Drugs Differentiated in Human Liver Slices

2017 ◽  
Vol 18 (3) ◽  
pp. 574 ◽  
Author(s):  
Alison Vickers ◽  
Anatoly Ulyanov ◽  
Robyn Fisher
Keyword(s):  
Human Liver ◽  
Liver Slices ◽  
Clinical Drugs ◽  
Human Liver Slices

Cryopreservation of pig and human liver slices

Cryobiology ◽  
1991 ◽  
Vol 28 (2) ◽  
pp. 131-142 ◽  
Author(s):  
Robyn Fisher ◽  
Charles W. Putnam ◽  
Lawrence J. Koep ◽  
I.Glenn Sipes ◽  
A.Jay Gandolfi ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Slices ◽  
Human Liver Slices

THE METABOLISM OF ALDOSTERONE BY SURVIVING DOG AND HUMAN LIVER SLICES

1960 ◽  
Vol 38 (1) ◽  
pp. 739-756
Author(s):  
Thomas Sandor ◽  
Wojciech J. Nowaczynski ◽  
Jacques Genest
Keyword(s):  
Human Liver ◽  
Chemical Characterization ◽  
Liver Slices ◽  
Metabolic Products ◽  
Reducing Substances ◽  
Dog Liver ◽  
Human Liver Slices ◽  
Acetate Form

Surviving dog liver slices were incubated with d,l-aldosterone-21-monoacetate, d,l-aldosterone, d-aldosterone, and d-aldosterone-21-C14. Human liver slices were incubated with d,l-aldosterone-21-monoacetate and d-aldosterone. The incubations were performed in a Krebs–Ringer–phosphate medium (pH 7.4), with 200 mg glucose added per 100 ml of medium, at a temperature of 37 °C. After incubation, the medium was extracted with chloroform and the crude extract extensively fractionated on column and paper chromatographic systems. In addition to free aldosterone, four metabolic products were isolated, two ring A reduced α-ketolic and two ultraviolet absorbing, non-reducing substances. The partial chemical characterization of these metabolites was attempted. The search for aldosterone metabolites in human urine resulted in the isolation of a substance in acetate form from the urine of a patient suffering from primary aldosteronism which may be identical with one of the ring A reduced metabolites obtained in the in vitro experiments.

Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevantex vivomodel of liver infection

Hepatology ◽  
2012 ◽  
Vol 56 (3) ◽  
pp. 861-872 ◽  
Author(s):  
Sylvie Lagaye ◽  
Hong Shen ◽  
Bertrand Saunier ◽  
Michelina Nascimbeni ◽  
Jesintha Gaston ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Liver ◽  
Liver Slices ◽  
Efficient Replication ◽  
Human Liver Slices ◽  
Virus Isolates ◽  
Liver Infection

Cytochrome P450 (CYP) isoenzymes in cultured precision-cut human liver slices: Effects of oxygen tension

1998 ◽  
Vol 95 ◽  
pp. 99
Author(s):  
C. Lerche-Langrand ◽  
V. Moronvalle-Halley ◽  
D. Chevalier ◽  
D. Hoët ◽  
D. Leroy ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Oxygen Tension ◽  
Human Liver ◽  
Liver Slices ◽  
Human Liver Slices

Induction of CYP3A isoforms in cultured precisioncut human liver slices

Xenobiotica ◽  
1997 ◽  
Vol 27 (11) ◽  
pp. 1165-1173 ◽  
Author(s):  
B. G. LAKE ◽  
S. E. BALL ◽  
A. B. RENWICK ◽  
J. M. TREDGER ◽  
J. KAO ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Slices ◽  
Human Liver Slices

Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices

Xenobiotica ◽  
1996 ◽  
Vol 26 (3) ◽  
pp. 297-306 ◽  
Author(s):  
B. G. Lake ◽  
C. Charzat ◽  
J. M. Tredger ◽  
A. B. Renwick ◽  
J. A. Beamand ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Slices ◽  
Human Liver Slices
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