Efficient replication of primary or culture hepatitis C virus isolates in human liver slices: A relevantex vivomodel of liver infection

Hepatology ◽  
2012 ◽  
Vol 56 (3) ◽  
pp. 861-872 ◽  
Author(s):  
Sylvie Lagaye ◽  
Hong Shen ◽  
Bertrand Saunier ◽  
Michelina Nascimbeni ◽  
Jesintha Gaston ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Liver ◽  
Liver Slices ◽  
Efficient Replication ◽  
Human Liver Slices ◽  
Virus Isolates ◽  
Liver Infection

654 PRODUCTION OF INFECTIOUS HEPATITIS C VIRUS IN A PRIMARY CULTURE OF HUMAN LIVER SLICES

2010 ◽  
Vol 52 ◽  
pp. S255
Author(s):  
S. Lagaye ◽  
H. Shen ◽  
J. Gaston ◽  
M. Nascimbeni ◽  
M. Triyatni ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Primary Culture ◽  
Human Liver ◽  
Infectious Hepatitis ◽  
Liver Slices ◽  
Human Liver Slices

scholarly journals Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model

2016 ◽  
Vol 8 (21) ◽  
pp. 902 ◽  
Author(s):  
Sylvie Lagaye ◽  
Sonia Brun ◽  
Jesintha Gaston ◽  
Hong Shen ◽  
Ruzena Stranska ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Liver ◽  
Liver Slices ◽  
Autophagy Inhibitor ◽  
Human Liver Slices

scholarly journals Genetic diversity and evolution of hepatitis C virus – 15 years on

2004 ◽  
Vol 85 (11) ◽  
pp. 3173-3188 ◽  
Author(s):  
Peter Simmonds
Keyword(s):  
Genetic Diversity ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Liver ◽  
Large Population ◽  
Sequence Divergence ◽  
Selection Pressures ◽  
Host Interactions ◽  
Persistent Viruses ◽  
The Face

In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about its role as a major causative agent of human liver disease and its ability to persist in the face of host-cell defences and the immune system. This review describes what is known about the diversity of HCV, the current classification of HCV genotypes within the family Flaviviridae and how this genetic diversity contributes to its pathogenesis. On one hand, diversification of HCV has been constrained by its intimate adaptation to its host. Despite the >30 % nucleotide sequence divergence between genotypes, HCV variants nevertheless remain remarkably similar in their transmission dynamics, persistence and disease development. Nowhere is this more evident than in the evolutionary conservation of numerous evasion methods to counteract the cell's innate antiviral defence pathways; this series of highly complex virus–host interactions may represent key components in establishing its ‘ecological niche’ in the human liver. On the other hand, the mutability and large population size of HCV enables it to respond very rapidly to new selection pressures, manifested by immune-driven changes in T- and B-cell epitopes that are encountered on transmission between individuals with different antigen-recognition repertoires. If human immunodeficiency virus type 1 is a precedent, future therapies that target virus protease or polymerase enzymes may also select very rapidly for antiviral-resistant mutants. These contrasting aspects of conservatism and adaptability provide a fascinating paradigm in which to explore the complex selection pressures that underlie the evolution of HCV and other persistent viruses.

Comparative evaluation of five rapid methods for identifying subtype 1b and 2c hepatitis C virus isolates

1997 ◽  
Vol 66 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Marialinda Vatteroni ◽  
Fabrizio Maggi ◽  
Antonietta Morrica ◽  
Claudia Fornai ◽  
Massimo Giorgi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Comparative Evaluation ◽  
Rapid Methods ◽  
Subtype 1B ◽  
Virus Isolates

scholarly journals Production and release of infectious hepatitis C virus from human liver cell cultures in the three-dimensional radial-flow bioreactor

Virology ◽  
2003 ◽  
Vol 314 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Hideki Aizaki ◽  
Seishi Nagamori ◽  
Mami Matsuda ◽  
Hayato Kawakami ◽  
Osamu Hashimoto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Cultures ◽  
Liver Cell ◽  
Human Liver ◽  
Radial Flow ◽  
Three Dimensional ◽  
Infectious Hepatitis ◽  
Human Liver Cell ◽  
Radial Flow Bioreactor
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