scholarly journals Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling

2017 ◽  
Vol 18 (3) ◽  
pp. 524 ◽  
Author(s):  
Zhi Xu ◽  
Chun-Ming Huang ◽  
Zhe Shao ◽  
Xiao-Ping Zhao ◽  
Meng Wang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Carcinoma Cells ◽  
Areca Nut ◽  
Oxygen Species ◽  
Ampk Signaling

A new biosafe reactive oxygen species responsive nanoplatform for targeted oral squamous cell carcinoma therapy

2019 ◽  
Vol 9 (9) ◽  
pp. 1076-1081 ◽  
Author(s):  
Fengying Wang ◽  
Miao Wang ◽  
Lu Zhao ◽  
Qing Li
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Stability ◽  
Drug Loading ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Target Cancer

A new reactive oxygen species (ROS)-responsive drug delivery systems (DDSs) needs development and has excellent application prospect. In this study, FA-PEG-TK-PLGA copolymer containing a ROS-responsive TK linker was designed and generated. The polymer self-assembled into stable small-sized DDSs into with hydrophilic PEG shells and hydrophobic PLGA cores, which exhibited high stability in aqueous solutions, besides an adequate drug loading capacity, excellent ROS sensitivity. high stability and good compatibility. Folic acid (FA) in the DDS presented here was used to target cancer cells. The polymer presents great potential as a novel DDSs for Oral squamous cell carcinoma (OSCC) therapy.

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