scholarly journals Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology

2017 ◽  
Vol 18 (2) ◽  
pp. 458 ◽  
Author(s):  
Zhaohui Ni ◽  
Yan Chen ◽  
Edison Ong ◽  
Yongqun He
Keyword(s):  
Antibiotic Resistance ◽  
Acinetobacter Baumannii ◽  
Resistance Determinant ◽  
Reverse Vaccinology ◽  
Antibiotic Resistance Determinant

scholarly journals Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23606 ◽  
Author(s):  
Zhongjie Liang ◽  
Lianchun Li ◽  
Yuanyuan Wang ◽  
Limin Chen ◽  
Xiangqian Kong ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Molecular Basis ◽  
Resistance Determinant ◽  
Antibiotic Resistance Determinant

scholarly journals A multicopy suppressor screening approach as a means to identify antibiotic resistance determinant candidates in Yersinia pestis

2008 ◽  
Vol 8 (1) ◽  
pp. 122 ◽  
Author(s):  
Karen L Stirrett ◽  
Julian A Ferreras ◽  
Sebastian M Rossi ◽  
Richard L Moy ◽  
Fabio V Fonseca ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Yersinia Pestis ◽  
Resistance Determinant ◽  
Multicopy Suppressor ◽  
Screening Approach ◽  
Antibiotic Resistance Determinant

scholarly journals The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV)

2013 ◽  
Vol 41 (22) ◽  
pp. 10062-10076 ◽  
Author(s):  
Ján Burian ◽  
Grace Yim ◽  
Michael Hsing ◽  
Peter Axerio-Cilies ◽  
Artem Cherkasov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Sigma Factor ◽  
Transcriptional Activator ◽  
Resistance Determinant ◽  
Antibiotic Resistance Determinant

scholarly journals Further studies on the antibiotic resistance of Shigella sonnei: II. The acquisition of transferable antibiotic resistance in vivo

1968 ◽  
Vol 66 (3) ◽  
pp. 479-487 ◽  
Author(s):  
Joan R. Davies ◽  
W. N. Farrant ◽  
A. J. H. Tomlinson
Keyword(s):  
Drug Resistance ◽  
Antibiotic Resistance ◽  
Shigella Sonnei ◽  
Resistance Determinant ◽  
Resistance Transfer ◽  
Antibiotic Resistance Determinant

A method is described for the testing of strains of Sh. sonnei for antibiotic resistance, colicine type and drug resistance transfer using a multiple inoculator.The examination of 731 strains of Sh. sonnei isolated from convalescent cases and their family contacts showed that about 5% of individuals were excreting organisms which differed from the infecting strain by a single transferable antibiotic resistance determinant. It is suggested that the acquisition of such resistance may occur in 13% of family incidents.

scholarly journals Interaction of Acinetobacter baumannii with Human Serum Albumin: Does the Host Determines the Outcome?

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 833
Author(s):  
Camila Pimentel ◽  
Casin Le ◽  
Marisel R. Tuttobene ◽  
Tomas Subils ◽  
Krisztina M. Papp-Wallace ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Human Serum Albumin ◽  
Quorum Sensing ◽  
Serum Albumin ◽  
Human Serum ◽  
Acinetobacter Baumannii ◽  
Biofilm Formation ◽  
Model Systems ◽  
Expression Levels ◽  
Multiple Drugs

Acinetobacter baumannii has become a serious threat to human health due to its extreme antibiotic resistance, environmental persistence, and capacity to survive within the host. Two A. baumannii strains, A118 and AB5075, commonly used as model systems, and three carbapenem-resistant strains, which are becoming ever more dangerous due to the multiple drugs they can resist, were exposed to 3.5% human serum albumin (HSA) and human serum (HS) to evaluate their response with respect to antimicrobial resistance, biofilm formation, and quorum sensing, all features responsible for increasing survival and persistence in the environment and human body. Expression levels of antibiotic resistance genes were modified differently when examined in different strains. The cmlA gene was upregulated or downregulated in conditions of exposure to 3.5% HSA or HS depending on the strain. Expression levels of pbp1 and pbp3 tended to be increased by the presence of HSA and HS, but the effect was not seen in all strains. A. baumannii A118 growing in the presence of HS did not experience increased expression of these genes. Aminoglycoside-modifying enzymes were also expressed at higher or lower levels in the presence of HSA or HS. Still, the response was not uniform; in some cases, expression was enhanced, and in other cases, it was tapered. While A. baumannii AB5075 became more susceptible to rifampicin in the presence of 3.5% HSA or HS, strain A118 did not show any changes. Expression of arr2, a gene involved in resistance to rifampicin present in A. baumannii AMA16, was expressed at higher levels when HS was present in the culture medium. HSA and HS reduced biofilm formation and production of N-Acyl Homoserine Lactone, a compound intimately associated with quorum sensing. In conclusion, HSA, the main component of HS, stimulates a variety of adaptative responses in infecting A. baumannii strains.

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