scholarly journals Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing

2016 ◽  
Vol 17 (5) ◽  
pp. 750 ◽  
Author(s):  
Alex Vorsters ◽  
Severien Van Keer ◽  
Samantha Biesmans ◽  
Annick Hens ◽  
Ilse De Coster ◽  
...  
Keyword(s):  
Hpv Infection ◽  
Dna Testing ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Long Term Follow Up

Abstract 551: Human papillomavirus (HPV) infection characteristics in a cohort of men who have sex with men (MSM) during long-term follow-up

2012 ◽  
Author(s):  
Dorothy J. Wiley ◽  
Xiuhong Li ◽  
Hilary K. Hsu ◽  
Stephen Young ◽  
Ross D. Cranston ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Infection ◽  
Long Term Follow Up ◽  
Sex With Men

Three-Year Follow-up for Women 30 Years and Older with Negative Pap and Negative Hybrid Capture 2 HPV DNA Testing Results

2012 ◽  
Vol 1 (1) ◽  
pp. S40
Author(s):  
Marilyn Dawlett ◽  
Teresa Kologinczak ◽  
Jian-Ping Wang ◽  
Nour Sneige ◽  
Therese Bevers ◽  
...  
Keyword(s):  
Dna Testing ◽  
Hybrid Capture ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Hybrid Capture 2

Cervical Cancer Screening

2008 ◽  
Vol 6 (1) ◽  
pp. 58 ◽  
Author(s):  
_ _
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Current Method ◽  
Dna Testing ◽  
Abnormal Cytology ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Recent Version

Cervical carcinoma remains a health issue for women worldwide. Cervical cytology screening is the current method for early detection, and the NCCN Cervical Cancer Screening Clinical Practice Guidelines in Oncology provide direction for evaluating and managing this process, including clarified and revised recommendations on screening techniques and intervals and follow-up of abnormal screening results, including colposcopy. Human papillomavirus (HPV) DNA testing for primary cervical cancer has been approved by the FDA, and HPV DNA testing for high-risk virus types can also be used as a component of both primary screening and workup of abnormal cytology results. Colposcopy, along with colposcopically directed biopsies, has become the primary method for evaluating women with abnormal cervical cytologies. Special considerations for colposcopy performed during pregnancy are also discussed. For the most recent version of the guidelines, please visit NCCN.org

p16/Ki-67 Immunocytochemistry in Gynecological Cytology: Limitations in Practice

2017 ◽  
Vol 61 (3) ◽  
pp. 230-236 ◽  
Author(s):  
Peter Ziemke
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Positive Result ◽  
Dna Testing ◽  
Ki 67 ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Immunochemical Detection ◽  
High Risk Hpv

Objective: Immunochemical detection of the protein p16INK4a in cervical cytology is used in combination with Ki-67. Cells positive for both proteins are certain to have been transformed by high-risk HPV. p16/Ki-67 immunocytochemistry provides a significant improvement in specificity over cytology and HPV DNA testing. However, p16/Ki-67 immunocytochemistry also has its limitations. Study Design: The research is based on the follow-up of 1,131 patients for whom p16/Ki-67 immunocytochemistry was performed with cytology. Dependencies on the age of patients with LSIL, number of p16/Ki-67-positive cells, and different results during repeated examinations were analyzed. Results: In LSIL, positive p16/Ki-67 is less specific for ≥CIN2/HSIL for patients younger than 30 years compared to patients aged 30 years or older (61.1 vs. 75.7%, p < 0.013). Using a score of 10 p16/Ki-67-marked cells as a positive result instead of 1 led to significantly higher specificity (89.0 vs. 70.2%, p < 0.001). This modified threshold offers better risk assessment in LSIL. In repeated immunocytochemical investigations, 28.4% of the results deviated from the first examination. Conclusion: The abovementioned discrepancies can be interpreted as hints about the molecular biological causes of suboptimal performance of p16/Ki-67. An efficient and reliable application of p16/Ki-67 immunocytochemistry requires knowledge of its methodological limitations.

scholarly journals Modern concepts of epidemiologyHPV-infection

2013 ◽  
Vol 62 (5) ◽  
pp. 3-14
Author(s):  
Kseniya Yevgenyevna Semenova ◽  
Armine Robertovna Khachaturyan
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Age Groups ◽  
Treatment Strategies ◽  
Hpv Infection ◽  
Dna Testing ◽  
Transmitted Infection ◽  
Hpv Dna ◽  
Sexually Transmitted ◽  
Hpv Dna Testing

Human papillomavirus (HPV) is widespread sexually transmitted infection, which is defined by high risk of contagion and high cancer potential. HPV extension depends on patiens age, residence, opportunites of diagnostics, etc. There are general methods of HPV-diagnostics such as HPV DNA testing, cytological, hystological methods, which are not always useful in detection of transitory and persistent HPV-infection forms. Nowadays, there is acute need to develop new diagnostic and prognostic methods, treatment strategies for patients from various age groups, having different infection formss.

scholarly journals Prevalence of human papillomavirus genotype among Moroccan women during a local screening program

2010 ◽  
Vol 4 (11) ◽  
pp. 732-739 ◽  
Author(s):  
Zaitouna Alhamany ◽  
Mohammed El Mzibri ◽  
Aicha Kharbach ◽  
Abderrahman Malihy ◽  
Redouane Abouqal ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Dna Testing ◽  
Cervical Lesions ◽  
Abnormal Cytology ◽  
Hpv 16 ◽  
Hpv Dna ◽  
Hpv Dna Testing ◽  
Moroccan Women

Introduction: Many studies have indicated a causal relationship between genital human papillomavirus (HPV) infections and cervical cancer. This study aimed to determine the prevalence and genotypes of six high-risk oncogenic human papillomaviruses in cervical lesions from Moroccan women with normal and abnormal cytology. Methodology: The study included 938 women from the Children's and Mothers' Pathology Department of Ibn Sina Hospital, Rabat. Cytopathology examination was done by routine PAP smear testing. HPV DNA testing was conducted using DNA amplification by Polymerase Chain Reaction with subsequent typing by hybridization with specific probes for HPV types 16, 18, 31, 33, 35 and 45. Results: Cytopathology testing showed that only 16.3 % had an abnormal cytology, with a predominance of atypical squamous cell of undetermined significance (ASCUS) cases. The overall HPV prevalence was 15.7%. According to the cytology results, HPV infection was detected in 15.8% of normal and 14.38% of abnormal cases. Specific HPV genotyping showed a predominance of HPV 16 and 18. Double infection (HPV 16 + 18) was found in two cases whereas multiple infections (HPV 16+18+31) were detected in only one case. Evaluation of the relationship between HPV status and some environmental risk factors, including individual, socio-economic, and hygiene status, showed a significant association between HPV infection and oral contraceptive use. Conclusion: Based on these data, a combination of cytology and HPV DNA testing allows for identification of patients with a high risk of developing high-grade cervical lesions and improves cervical cancer prevention.

Sign in / Sign up

Export Citation Format

Share Document