scholarly journals Chronic Heat Stress Induces Immune Response, Oxidative Stress Response, and Apoptosis of Finishing Pig Liver: A Proteomic Approach

2016 ◽  
Vol 17 (5) ◽  
pp. 393 ◽  
Author(s):  
Yanjun Cui ◽  
Yue Hao ◽  
Jielei Li ◽  
Weiguang Bao ◽  
Gan Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Heat Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Pig Liver ◽  
Proteomic Approach ◽  
Finishing Pig

scholarly journals Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematodeCaenorhabditis remanei

2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Christine H O’Connor ◽  
Kristin L Sikkink ◽  
Thomas C Nelson ◽  
Janna L Fierst ◽  
William A Cresko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Stress Response ◽  
Complex Traits ◽  
Genetic Architecture ◽  
Oxidative Stress Response ◽  
Pleiotropic Effects ◽  
General View ◽  
Acute Heat Stress ◽  
And Oxidative Stress

AbstractThe adaptation of complex organisms to changing environments has been a central question in evolutionary quantitative genetics since its inception. The structure of the genotype–phenotype maps is critical because pleiotropic effects can generate widespread correlated responses to selection and potentially restrict the extent of evolutionary change. In this study, we use experimental evolution to dissect the genetic architecture of natural variation for acute heat stress and oxidative stress response in the nematode Caenorhabiditis remanei. Previous work in the classic model nematode Caenorhabiditis elegans has found that abiotic stress response is controlled by a handful of genes of major effect and that mutations in any one of these genes can have widespread pleiotropic effects on multiple stress response traits. Here, we find that acute heat stress response and acute oxidative response in C. remanei are polygenic, complex traits, with hundreds of genomic regions responding to selection. In contrast to expectation from mutation studies, we find that evolved acute heat stress and acute oxidative stress response for the most part display independent genetic bases. This lack of correlation is reflected at the levels of phenotype, gene expression, and in the genomic response to selection. Thus, while these findings support the general view that rapid adaptation can be generated by changes at hundreds to thousands of sites in the genome, the architecture of segregating variation is likely to be determined by the pleiotropic structure of the underlying genetic networks.

scholarly journals Inhibition of the oxidative stress response by heat stress inCaenorhabditis elegans

2016 ◽  
Vol 219 (14) ◽  
pp. 2201-2211 ◽  
Author(s):  
Timothy A. Crombie ◽  
Lanlan Tang ◽  
Keith P. Choe ◽  
David Julian
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Stress Response ◽  
Oxidative Stress Response

scholarly journals Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei

2019 ◽  
Author(s):  
Christine H. O’Connor ◽  
Kristin L. Sikkink ◽  
Thomas C. Nelson ◽  
Janna L. Fierst ◽  
William A. Cresko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Stress Response ◽  
Complex Traits ◽  
Genetic Architecture ◽  
Oxidative Stress Response ◽  
Pleiotropic Effects ◽  
General View ◽  
Acute Heat Stress ◽  
And Oxidative Stress

ABSTRACTThe adaptation of complex organisms to changing environments has been a central question in evolutionary quantitative genetics since its inception. The structure of the genotype-phenotype maps is critical because pleiotropic effects can generate widespread correlated responses to selection and potentially restrict the extent of evolutionary change. In this study we use experimental evolution to dissect the genetic architecture of natural variation for acute heat stress and oxidative stress response in the nematode Caenorhabiditis remanei. Previous work in the classic model nematode C. elegans has found that abiotic stress response is controlled by a handful of genes of major effect and that mutations in any one of these genes can have widespread pleiotropic effects on multiple stress response traits. Here, we find that acute heat stress response and acute oxidative response in C. remanei are polygenic, complex traits, with hundreds of genomic regions responding to selection. In contrast to expectation from mutation studies, we find that evolved acute heat stress and acute oxidative stress response for the most part display independent genetic bases. This lack of correlation is reflected at the levels of phenotype, gene expression, and in the genomic response to selection. Thus, while these findings support the general view that rapid adaptation can be generated by changes at hundreds to thousands of sites in the genome, the architecture of segregating variation is likely to be strongly parcellated by the pleiotropic structure of the underlying genetic networks.

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