scholarly journals A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent

2016 ◽  
Vol 17 (4) ◽  
pp. 546 ◽  
Author(s):  
Eun Oh ◽  
Jong Park ◽  
Ji Lee ◽  
Cheol Myung ◽  
Su Kim ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2B

Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level

2005 ◽  
Vol 18 (2) ◽  
pp. 113
Author(s):  
Myung Ha Yoon ◽  
Hong Buem Bae ◽  
Jeong Il Choi ◽  
Seok Jae Kim ◽  
Chang Mo Kim ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtype ◽  
Analgesic Action ◽  
Spinal Level ◽  
Subtype 3

scholarly journals 176 Serotonin receptor 2b (5-ht2b) modulates cardiomyocyte proliferation by regulating the hippo pathway

Heart ◽  
2017 ◽  
Vol 103 (Suppl 5) ◽  
pp. A122.2-A122 ◽  
Author(s):  
Dowan Kwon ◽  
Yulia Kohar ◽  
Nicholas Stafford ◽  
Delvac Oceandy
Keyword(s):  
Serotonin Receptor ◽  
Hippo Pathway ◽  
Cardiomyocyte Proliferation ◽  
Serotonin Receptor 2B ◽  
The Hippo Pathway

scholarly journals Role of some types of serotonin receptors in murine hypophyseal-testicular complex activation induced by the presence of a female

2003 ◽  
Vol 49 (6) ◽  
pp. 53-56
Author(s):  
T. G. Amstislavskaya ◽  
N. K. Popova
Keyword(s):  
Serotonin Receptors ◽  
Receptor Agonist ◽  
Serotonin Receptor ◽  
Receptive Female ◽  
Plasma Testosterone ◽  
Blood Levels ◽  
Inhibitory Effects ◽  
Sexual Activation ◽  
Different Types

Placement of a sexually receptive female mouse behind a partition that prevents physical contacts, but permits it to see and smell caused an increase in the blood levels of testosterone in male mice. The selective 5-HTIA-serotonin receptor agonist 08-OH- DPAT (0.1 mg/kg) and the mixed 5-HTIA/IB agonist eltoprazine, 3.0 and 10.0 mg/kg, blocked the activating effect of female exposure on the male pituitary-testicular system. The 5-HT/-receptor agonist p-MPPI (0.2 mg/kg) prevented the inhibitory effects of 8-OH-DPATand eltoprazine. The 5-HT/B-receptor agonist CGS- 12066A (1.0 and 2.0 mg/kg) exerted no effect while the mixed 5-HTIB/2C-receptor agonist TFMPP (5.2 mg/kg) inhibited a female-induced increase in the levels of male blood testosterone. The 5-HT/-receptor agonist keranserin (1.0 and 2.0 mg/kg) prevented a female-induced increase in the levels of testosterone. The 5-HT3-receptor agonist ondansetron (0.05 and 0.1 mg/kg) elevated the baseline level of plasma testosterone, but blocked receptive female-induced activation of the male hypothalamic-pituitary-testicular system (HPTS). It is concluded that 5-HTIA-receptors are involved in the control of male sexual activation. At the same time different types and even subtypes of the same type of 5-HT-receptors produce varying inhibitory and activating effects on the receptive female-induced activation of HPTS. Blocking of the female-induced activation of HPTS seems to be realized by involving 5-HTu- and 5-HT2C-receptors and its activation occurs with the participation of 5-HT^- and 5- HT3-receptors.

Reflex pressor response to arterial phenylbiguanide: role of abdominal sympathetic visceral afferents

1998 ◽  
Vol 275 (6) ◽  
pp. H2025-H2035 ◽  
Author(s):  
Liang-Wu Fu ◽  
John C. Longhurst
Keyword(s):  
Serotonin Receptor ◽  
Pressor Response ◽  
Left Ventricular ◽  
Vagal Afferents ◽  
Visceral Afferents ◽  
Reflex Response ◽  
Selective Agonist ◽  
Cervical Vagotomy ◽  
Increased Activity

Phenylbiguanide (PBG), a 5-HT3 (serotonin) receptor agonist, has been used in many studies as a “selective” agonist to elicit reflex bradycardia and hypotension through activation of cardiac and pulmonary vagal afferents. Because we have shown that endogenous 5-HT stimulates ischemically sensitive abdominal sympathetic afferents through 5-HT3 receptors, we investigated the possibility that left ventricular (LV) and intra-arterial administration of PBG may evoke a competing reflex response by increasing the activity of sympathetic visceral afferents in anesthetized cats. Mean arterial pressure (MAP) and heart rate (HR) were monitored. When both vagal and sympathetic afferents were intact, PBG (40 μg/kg, injected into the LV) significantly decreased MAP and HR in 8 of 10 cats but increased MAP in the remaining 2 cats. After bilateral cervical vagotomy, LV PBG significantly increased MAP. PBG (40 μg/kg ia) significantly increased MAP and HR, whereas intravenous PBG significantly decreased MAP and HR ( n = 10 cats). Furthermore, the pressor response to PBG (40 μg /kg ia) was reduced by 68% ( P < 0.05; n = 4 cats) by celiac and mesenteric ganglionectomies. In studies of single-unit abdominal sympathetic afferents, intra-arterial but not intravenous PBG (40 μg/kg) significantly increased activity of 10 ischemically sensitive afferents but not ischemically insensitive afferents. Blockade of 5-HT3 receptors with tropisetron (200 μg/kg iv) eliminated the response of the afferents and the pressor response to PBG. These data indicate that PBG administered into the LV usually, but not always, evokes a depressor response that is converted to a pressor response following cervical vagotomy. Also, intra-arterial PBG induces a pressor response by stimulating 5-HT3receptors largely associated with ischemically sensitive abdominal sympathetic afferents.

No Association between a Polymorphism in the Serotonin Receptor 2B (HTR2B) Gene and Personality Traits in Healthy Japanese Subjects

2013 ◽  
Vol 68 (1) ◽  
pp. 59-62 ◽  
Author(s):  
Shoko Tsuchimine ◽  
Takeshi Taniguchi ◽  
Norio Sugawara ◽  
Ayako Kaneda ◽  
Norio Yasui-Furukori
Keyword(s):  
Personality Traits ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2B ◽  
Japanese Subjects

The human serotonin receptor 2B

2004 ◽  
Vol 14 (12) ◽  
pp. 805-811 ◽  
Author(s):  
Zhicheng Lin ◽  
Donna Walther ◽  
Xiao-Ying Yu ◽  
Tomas Drgon ◽  
George R Uhl
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2B
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