scholarly journals The role of the serotonin receptor subtypes 5-HT1A and 5-HT7 and its interaction in emotional learning and memory

2015 ◽  
Vol 6 ◽  
Author(s):  
Oliver Stiedl ◽  
Elpiniki Pappa ◽  
Ã…sa Konradsson-Geuken ◽  
Sven Ove Ögren
Keyword(s):  
Learning And Memory ◽  
Serotonin Receptor ◽  
Emotional Learning ◽  
Receptor Subtypes

scholarly journals Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

1999 ◽  
Vol 127 (5) ◽  
pp. 1190-1194 ◽  
Author(s):  
G Grignaschi ◽  
E Fanelli ◽  
I Scagnol ◽  
R Samanin
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtypes

Preclinical evidence for the role of serotonin receptor-subtypes in depression

1992 ◽  
Vol 4 (2) ◽  
pp. 40-45
Author(s):  
B. Olivier ◽  
J. Schipper ◽  
J.A.M. van der Heyden ◽  
A. van Hest ◽  
J. Mos ◽  
...  
Keyword(s):  
Animal Models ◽  
Clinical Research ◽  
Serotonin Receptor ◽  
Antidepressant Effect ◽  
Receptor Subtypes ◽  
Research Support ◽  
Receptor Agonists ◽  
Animal Models Of Depression ◽  
Literature Evidence

SummarySerotonin (5-HT) plays an important role in depression and specific 5-HT reuptake blockers appear to be clinically important antidepressants. It is unclear however, which serotonergic mechanism is involved in the antidepressant effect, certainly when regarding the existence of at least seven 5-HT receptor subtypes. By testing different 5-HT ligands in two animal models of depression (forced swimming and DRL72-S test) and comparison with data from literature, evidence is provided for potential antidepressant qualities of 5-HT1A receptor-agonists and 5-HT1C receptor-antagonists. Compounds binding to 5-HT1B, 5-HT2 and 5-HT3 receptors do not have an antidepressant profile. Results of clinical research support the predicted antidepressive effects of 5-HT1A receptor-agonists.

scholarly journals Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission

2020 ◽  
Vol 72 (6) ◽  
pp. 1593-1603
Author(s):  
Monika Herian ◽  
Adam Wojtas ◽  
Małgorzata Katarzyna Sobocińska ◽  
Mateusz Skawski ◽  
Alejandro González-Marín ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Serotonin Receptor ◽  
Glutamate Release ◽  
Local Administration ◽  
Receptor Subtypes ◽  
Microdialysis Probe ◽  
Selective Antagonists ◽  
Freely Moving ◽  
Rat Frontal Cortex

Abstract Background 4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin (5-HT) receptor agonist with hallucinogenic properties. The aim of our research was to examine the role of the 5-HT2A, 5-HT2C and 5-HT1A serotonin receptor subtypes in 25I-NBOMe hallucinogenic activity and its effect on dopamine (DA), 5-HT and glutamate release in the rat frontal cortex. Methods Hallucinogenic activity was investigated using the wet dog shake (WDS) test. The release of DA, 5-HT and glutamate in the rat frontal cortex was studied using a microdialysis in freely moving rats. Neurotransmitter levels were analyzed by HPLC with electrochemical detection. The selective antagonists of the 5-HT2A, 5-HT2C and 5-HT1A serotonin receptor subtypes: M100907, SB242084 and WAY100635, respectively were applied through a microdialysis probe. Results The WDS response to 25I-NBOMe (1 and 3 mg/kg) was significantly reduced by local administration of M100907 and SB242084 (100 nM). The 25I-NBOMe-induced increase in glutamate, DA and 5-HT release was inhibited by M100907 and SB242084. WAY100635 had no effect on 25I-NBOMe-induced WDS and glutamate release, while it decreased DA and 5-HT release from cortical neuronal terminals. Conclusion The obtained results suggest that 5-HT2A and 5-HT2C receptors play a role in 25I-NBOMe-induced hallucinogenic activity and in glutamate, DA and 5-HT release in the rat frontal cortex as their respective antagonists attenuated the effect of this hallucinogen. The disinhibition of GABA cells by the 5-HT1A receptor antagonist seems to underlie the mechanism of decreased DA and 5-HT release from neuronal terminals in the frontal cortex.

The role of different serotonin receptor subtypes in seizure susceptibility

2013 ◽  
Vol 232 (2) ◽  
pp. 347-367 ◽  
Author(s):  
Mohammad Hadi Gharedaghi ◽  
Mohammad Seyedabadi ◽  
Jean-Eric Ghia ◽  
Ahmad Reza Dehpour ◽  
Reza Rahimian
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtypes ◽  
Seizure Susceptibility

scholarly journals The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance

2017 ◽  
Vol 6 (2) ◽  
pp. 217 ◽  
Author(s):  
Ercan Ozdemir
Keyword(s):  
Serotonin Receptor ◽  
Opioid Analgesic ◽  
Pain Modulation ◽  
Spinal Cord Dorsal Horn ◽  
Continuous Treatment ◽  
Opioid Analgesia ◽  
Receptor Subtypes ◽  
Analgesic Tolerance ◽  
Pathophysiological Role

Continuous treatment with opioid analgesics, such as morphine, leads to the development of ant nociceptive tolerance in patients. Although a lot of information about antinociceptive, the pathophysiological mechanisms of tolerance to opioid analgesia are not yet completely understood. Proposed mechanisms for opioid analgesic tolerance comprise down-regulation of opioid receptors, reduction of sensitivity G-proteins, altered intracellular signalling pathway including nitric oxide, adenyl cyclase, and protein kinase C. Numerous physiological and behavioural studies have shown an interaction of the serotonergic system and opioid antinociception. The serotonin (5-HT) receptor system is a necessary component of the spinal and midbrain pain modulation circuit mediating opioid analgesia. Various types of serotonin receptors demonstrate different effects on morphine analgesia. Systemic administration of opioids rise 5-HT levels in the spinal cord dorsal horn and contribute to opioid analgesia in the normal state but reduce that in neuropathic pain via spinal 5-HT3 receptors. Spinal and supraspinal serotonergic neurons may also play a pathophysiological role in the development of morphine analgesic tolerance. Serotonin receptor subtypes show different effects on opioid tolerance. This review paper focus on the current understanding of the role of serotonin receptor systems in opioid analgesia and tolerance.

Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception

2006 ◽  
Vol 54 (3) ◽  
pp. 195-202 ◽  
Author(s):  
P GIRARD ◽  
M COPPE ◽  
D VERNIERS ◽  
Y PANSART ◽  
J GILLARDIN
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtypes

Role of serotonin receptor subtypes in the development of amygdaloid kindling in rats

1997 ◽  
Vol 747 (2) ◽  
pp. 338-342 ◽  
Author(s):  
Yuji Wada ◽  
Jun Shiraishi ◽  
Mitsuhiko Nakamura ◽  
Yoshifumi Koshino
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtypes
Sign in / Sign up

Export Citation Format

Share Document