scholarly journals Activin A-Smad Signaling Mediates Connective Tissue Growth Factor Synthesis in Liver Progenitor Cells

2016 ◽  
Vol 17 (3) ◽  
pp. 408 ◽  
Author(s):  
Ze-Yang Ding ◽  
Guan-Nan Jin ◽  
Wei Wang ◽  
Yi-Min Sun ◽  
Wei-Xun Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Progenitor Cells ◽  
Connective Tissue Growth Factor ◽  
Activin A ◽  
Tissue Growth ◽  
Smad Signaling

Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression

2008 ◽  
Vol 28 (9) ◽  
pp. 1207-1216 ◽  
Author(s):  
Olav A. Gressner ◽  
Birgit Lahme ◽  
Monika Siluschek ◽  
Katharina Rehbein ◽  
Ralf Weiskirchen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Activin A ◽  
Tissue Growth ◽  
Ccn2 Expression

Actions of activin A, connective tissue growth factor, hepatocyte growth factor and teratocarcinoma-derived growth factor 1 on the development of the bovine preimplantation embryo

2017 ◽  
Vol 29 (7) ◽  
pp. 1329 ◽  
Author(s):  
Jasmine Kannampuzha-Francis ◽  
Paula Tribulo ◽  
Peter J. Hansen
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Hepatocyte Growth Factor ◽  
Connective Tissue Growth Factor ◽  
Activin A ◽  
Blastocyst Stage ◽  
Tissue Growth ◽  
Bioactive Molecules ◽  
Bovine Embryo ◽  
Hepatocyte Growth

The reproductive tract secretes bioactive molecules collectively known as embryokines that can regulate embryonic growth and development. In the present study we tested four growth factors expressed in the endometrium for their ability to modify the development of the bovine embryo to the blastocyst stage and alter the expression of genes found to be upregulated (bone morphogenetic protein 15 (BMP15) and keratin 8, type II (KRT8)) or downregulated (NADH dehydrogenase 1 (ND1) and S100 calcium binding protein A10 (S100A10)) in embryos competent to develop to term. Zygotes were treated at Day 5 with 0.01, 0.1 or 1.0 nM growth factor. The highest concentration of activin A increased the percentage of putative zygotes that developed to the blastocyst stage. Connective tissue growth factor (CTGF) increased the number of cells in the inner cell mass (ICM), decreased the trophectoderm : ICM ratio and increased blastocyst expression of KRT8 and ND1. The lowest concentration of hepatocyte growth factor (HGF) reduced the percentage of putative zygotes becoming blastocysts. Teratocarcinoma-derived growth factor 1 increased total cell number at 0.01 nM and expression of S100A10 at 1.0 nM, but otherwise had no effects. Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.

scholarly journals IL-13 Induces Connective Tissue Growth Factor in Rat Hepatic Stellate Cells via TGF-β–Independent Smad Signaling

2011 ◽  
Vol 187 (5) ◽  
pp. 2814-2823 ◽  
Author(s):  
Yan Liu ◽  
Christoph Meyer ◽  
Alexandra Müller ◽  
Frank Herweck ◽  
Qi Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Hepatic Stellate Cells ◽  
Stellate Cells ◽  
Tissue Growth ◽  
Smad Signaling

scholarly journals Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction

2004 ◽  
Vol 231 (3) ◽  
pp. 542-550 ◽  
Author(s):  
Susana M. Chuva De Sousa Lopes ◽  
Alie Feijen ◽  
Jeroen Korving ◽  
Olexander Korchynskyi ◽  
Jonas Larsson ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Heart Development ◽  
Tissue Growth ◽  
Mouse Heart ◽  
Smad Signaling ◽  
Factor Expression ◽  
Growth Factor Expression
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