scholarly journals Potential Effect of CD271 on Human Mesenchymal Stromal Cell Proliferation and Differentiation

2015 ◽  
Vol 16 (12) ◽  
pp. 15609-15624 ◽  
Author(s):  
Giovanna Calabrese ◽  
Raffaella Giuffrida ◽  
Debora Lo Furno ◽  
Nunziatina Parrinello ◽  
Stefano Forte ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Potential Effect ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice

Endocrine ◽  
2016 ◽  
Vol 53 (2) ◽  
pp. 595-606 ◽  
Author(s):  
Shuangbo Kong ◽  
Xue Han ◽  
Tongtong Cui ◽  
Chan Zhou ◽  
Yufei Jiang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stromal Cell ◽  
Endometrial Stromal Cell ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation

Impaired B-cell development at the pre-BII-cell stage in galectin-1–deficient mice due to inefficient pre-BII/stromal cell interactions

Blood ◽  
2009 ◽  
Vol 113 (23) ◽  
pp. 5878-5886 ◽  
Author(s):  
Marion Espeli ◽  
Stéphane J. C. Mancini ◽  
Caroline Breton ◽  
Françoise Poirier ◽  
Claudine Schiff
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Cell Differentiation ◽  
B Cell ◽  
Stromal Cell ◽  
Cell Phenotype ◽  
Cell Proliferation And Differentiation ◽  
Hydroxyurea Treatment ◽  
Proliferation And Differentiation ◽  
Deficient Mice

Abstract Activation of the pre-B-cell receptor (pre-BCR) in the bone marrow depends on both tonic and ligand-induced signaling and leads to pre-BII-cell proliferation and differentiation. Using normal mouse bone marrow pre-BII cells, we demonstrate that the ligand-induced pre-BCR activation depends on pre-BCR/galectin-1/integrin interactions leading to pre-BCR clustering at the pre-BII/stromal cell synapse. In contrast, heparan sulfates, shown to be pre-BCR ligands in mice, are not implicated in pre-BCR relocalization. Inhibition of pre-BCR/galectin-1/integrin interactions has functional consequences, since pre-BII-cell proliferation and differentiation are impaired in an in vitro B-cell differentiation assay, without affecting cellular apoptosis. Most strikingly, although galectin-1–deficient mice do not show an apparent B-cell phenotype, the kinetics of de novo B-cell reconstitution after hydroxyurea treatment indicates a specific delay in pre-BII-cell recovery due to a decrease in pre-BII-cell differentiation and proliferation. Thus, although it remains possible that the pre-BCR interacts with other ligands, these results highlight the role played by the stromal cell–derived galectin-1 for the efficient development of normal pre-BII cells and suggest the existence of pre-BII–specific stromal cell niches in normal bone marrow.

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