scholarly journals Structural Characterization of the Degradation Products of a Minor Natural Sweet Diterpene Glycoside Rebaudioside M under Acidic Conditions

2014 ◽  
Vol 15 (1) ◽  
pp. 1014-1025 ◽  
Author(s):  
Indra Prakash ◽  
Venkata Chaturvedula ◽  
Avetik Markosyan
Keyword(s):  
Structural Characterization ◽  
Degradation Products ◽  
Acidic Conditions ◽  
A Minor

scholarly journals Micro-structural Characterization of Inorganic Cryptomelane Nanomaterials Synthesized by Use of Controlled O2 and Cold Aging in Acidic Conditions

2006 ◽  
Vol 12 (S02) ◽  
pp. 740-741
Author(s):  
L Ma ◽  
T Hartmann ◽  
MA Cheney ◽  
N Birkner
Keyword(s):  
Structural Characterization ◽  
Acidic Conditions

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006

Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation

2012 ◽  
Vol 30 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Takayuki Furukawa ◽  
Misaki Arai ◽  
Fayna Garcia-Martin ◽  
Maho Amano ◽  
Hiroshi Hinou ◽  
...  
Keyword(s):  
High Throughput ◽  
Structural Characterization ◽  
Degradation Products ◽  
Enzymatic Fragmentation

Identification and structural characterization of four novel degradation products and a process impurity of isavuconazonium sulfate for injection formulation bulk by LC-ESI-QTOF-MS/MS

2019 ◽  
Vol 26 (2) ◽  
pp. 144-152
Author(s):  
Venkata Rama Prabhakara Sastry Regella ◽  
Venkatesan Chidambaram Subramanian ◽  
Sarveswara Sastry Bhetanabhotla
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Alkaline Hydrolysis ◽  
Degradation Products ◽  
Water Soluble ◽  
Tandem Mass ◽  
Light Conditions

Isavuconazonium sulfate is a highly water-soluble pro-drug of active triazole isavuconazole. The degradation profile of isavuconazonium sulfate for injection formulation bulk under acid hydrolysis, alkaline hydrolysis, oxidation, heat, and light conditions was studied using LC-PDA/MS technique. Four degradation products (DP1 to DP4) and one process impurity (PI1) were identified in isavuconazonium sulfate formulation bulk and characterized the identified impurities by liquid chromatography-electron spray ionization-quadruple-time of flight tandem mass spectrometry. Isavuconazole (DP1) was found to be one of the major degradation products of isavuconazonium sulfate.

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