Comprehensive degradation profiling and influence of different oxidising reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS

2021 ◽  
Author(s):  
Vivek Dhiman ◽  
Kanchan Patil ◽  
Laximan Velip ◽  
M. V. N. Kumar Talluri ◽  
S. Gananadhamu
Keyword(s):  
Structural Characterization ◽  
Degradation Products

Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation

2012 ◽  
Vol 30 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Takayuki Furukawa ◽  
Misaki Arai ◽  
Fayna Garcia-Martin ◽  
Maho Amano ◽  
Hiroshi Hinou ◽  
...  
Keyword(s):  
High Throughput ◽  
Structural Characterization ◽  
Degradation Products ◽  
Enzymatic Fragmentation

Identification and structural characterization of four novel degradation products and a process impurity of isavuconazonium sulfate for injection formulation bulk by LC-ESI-QTOF-MS/MS

2019 ◽  
Vol 26 (2) ◽  
pp. 144-152
Author(s):  
Venkata Rama Prabhakara Sastry Regella ◽  
Venkatesan Chidambaram Subramanian ◽  
Sarveswara Sastry Bhetanabhotla
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Alkaline Hydrolysis ◽  
Degradation Products ◽  
Water Soluble ◽  
Tandem Mass ◽  
Light Conditions

Isavuconazonium sulfate is a highly water-soluble pro-drug of active triazole isavuconazole. The degradation profile of isavuconazonium sulfate for injection formulation bulk under acid hydrolysis, alkaline hydrolysis, oxidation, heat, and light conditions was studied using LC-PDA/MS technique. Four degradation products (DP1 to DP4) and one process impurity (PI1) were identified in isavuconazonium sulfate formulation bulk and characterized the identified impurities by liquid chromatography-electron spray ionization-quadruple-time of flight tandem mass spectrometry. Isavuconazole (DP1) was found to be one of the major degradation products of isavuconazonium sulfate.

A study on structural characterization of degradation products of cangrelor using LC/QTOF/MS/MS and NMR

2019 ◽  
Vol 170 ◽  
pp. 327-334 ◽  
Author(s):  
Vinodh Guvvala ◽  
Venkatesan Chidambaram Subramanian ◽  
Jaya Shree Anireddy
Keyword(s):  
Structural Characterization ◽  
Degradation Products

Removal of dexamethasone by oxidative processes: structural characterization of degradation products and estimation of the toxicity

2021 ◽  
pp. 106884
Author(s):  
Amanda V. Quaresma ◽  
Karina T.S. Rubio ◽  
Jason G. Taylor ◽  
Bianca A. Sousa ◽  
Silvana Q. Silva ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Degradation Products ◽  
Oxidative Processes
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