scholarly journals EGFR-Ras-Raf Signaling in Epidermal Stem Cells: Roles in Hair Follicle Development, Regeneration, Tissue Remodeling and Epidermal Cancers

2013 ◽  
Vol 14 (10) ◽  
pp. 19361-19384 ◽  
Author(s):  
Eszter Doma ◽  
Christian Rupp ◽  
Manuela Baccarini
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Tissue Remodeling ◽  
Follicle Development ◽  
Epidermal Stem Cells ◽  
Hair Follicle Development

scholarly journals Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 466 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Hair Loss ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Regrowth ◽  
Hair Follicle Development

The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).

scholarly journals Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development

2018 ◽  
Vol 29 (22) ◽  
pp. 2784-2799 ◽  
Author(s):  
Swamy K. Tripurani ◽  
Yan Wang ◽  
Ying-Xin Fan ◽  
Massod Rahimi ◽  
Lily Wong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Hair Follicle ◽  
Transforming Growth Factor ◽  
Integration Site ◽  
Critical Role ◽  
Hair Follicles ◽  
Follicle Development ◽  
Genetic Ablation ◽  
Hair Follicle Development

Mice that lack the epidermal growth factor receptor (EGFR) fail to develop a hair coat, but the mechanism responsible for this deficit is not completely understood. Here, we show that EGFR plays a critical role to attenuate wingless-type MMTV integration site family member (Wnt)/β-catenin signaling during postnatal hair follicle development. Genetic ablation of EGFR in mice resulted in increased mitotic activity in matrix cells, apoptosis in hair follicles, and impaired differentiation of epithelial lineages that form hair. EGFR is activated in wild-type hair follicle stem cells marked with SOX9 or NFATc1 and is essential to restrain proliferation and support stem cell numbers and their quiescence. We observed elevated levels of Wnt4, 6, 7b, 10a, 10b, and 16 transcripts and hyperactivation of the β-catenin pathway in EGFR knockout follicles. Using primary keratinocytes, we linked ligand-induced EGFR activation to suppression of nascent mRNA synthesis of Wnt genes. Overexpression of the Wnt antagonist sFRP1 in mice lacking EGFR demonstrated that elevated Wnts are a major cause for the hair follicle defects. Colocalization of transforming growth factor α and Wnts regulated by EGFR in stem cells and progeny indicates that EGFR autocrine loops control Wnts. Our findings define a novel mechanism that integrates EGFR and Wnt/β-catenin pathways to coordinate the delicate balance between proliferation and differentiation during development.

The Nude Mouse Skin Phenotype: The Role of Foxn1 in Hair Follicle Development and Cycling

2001 ◽  
Vol 71 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Lars Mecklenburg ◽  
Motonobu Nakamura ◽  
John P. Sundberg ◽  
Ralf Paus
Keyword(s):  
Hair Follicle ◽  
Nude Mouse ◽  
Mouse Skin ◽  
Follicle Development ◽  
Hair Follicle Development

Epidermal stem cells arise from the hair follicle after wounding

2007 ◽  
Vol 21 (7) ◽  
pp. 1358-1366 ◽  
Author(s):  
Vered Levy ◽  
Catherine Lindon ◽  
Ying Zheng ◽  
Brian D. Harfe ◽  
Bruce A. Morgan
Keyword(s):  
Stem Cells ◽  
Hair Follicle ◽  
Epidermal Stem Cells

scholarly journals Factors Mediating the Interactions Between Epidermal and Dermal Cells in Skin Grafts that Might Be Important for Hair Follicle Development

1995 ◽  
Vol 104 (5) ◽  
pp. 21-22 ◽  
Author(s):  
Tonja Kartasova ◽  
Aline B. Scandurro ◽  
Mitchell F. Denning ◽  
Stuart H. Yuspa ◽  
Ulrike Lichti ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Follicle Development ◽  
Skin Grafts ◽  
Hair Follicle Development ◽  
Dermal Cells

scholarly journals Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243507
Author(s):  
Zhihong Wu ◽  
Erhan Hai ◽  
Zhengyang Di ◽  
Rong Ma ◽  
Fangzheng Shang ◽  
...  
Keyword(s):  
Network Analysis ◽  
Hair Follicle ◽  
Quantitative Polymerase Chain Reaction ◽  
Correlation Coefficients ◽  
Hair Follicles ◽  
Functional Enrichment ◽  
Follicle Development ◽  
Hub Genes ◽  
Cashmere Goats ◽  
Hair Follicle Development

Objective Mature hair follicles represent an important stage of hair follicle development, which determines the stability of hair follicle structure and its ability to enter the hair cycle. Here, we used weighted gene co-expression network analysis (WGCNA) to identify hub genes of mature skin and hair follicles in Inner Mongolian cashmere goats. Methods We used transcriptome sequencing data for the skin of Inner Mongolian cashmere goats from fetal days 45–135 days, and divided the co expressed genes into different modules by WGCNA. Characteristic values were used to screen out modules that were highly expressed in mature skin follicles. Module hub genes were then selected based on the correlation coefficients between the gene and module eigenvalue, gene connectivity, and Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The results were confirmed by quantitative polymerase chain reaction (qPCR). Results Ten modules were successfully defined, of which one, with a total of 3166 genes, was selected as a specific module through sample and gene expression pattern analyses. A total of 584 candidate hub genes in the module were screened by the correlation coefficients between the genes and module eigenvalue and gene connectivity. Finally, GO/KEGG functional enrichment analyses detected WNT10A as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats. qPCR showed that the expression trends of 13 genes from seven fetal skin samples were consistent with the sequencing results, indicating that the sequencing results were reliable.n

scholarly journals MLL histone methylases in estrogen‐mediated regulation of HOX genes involved in hair follicle development and leukemia

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Subhrangsu S Mandal ◽  
Khairul I Ansari ◽  
Imran Hussain ◽  
Sahba Kasiri ◽  
Bishakha Shrestha
Keyword(s):  
Hair Follicle ◽  
Hox Genes ◽  
Follicle Development ◽  
Hair Follicle Development
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