scholarly journals Scutellaria barbata D. Don Inhibits Tumor Angiogenesis via Suppression of Hedgehog Pathway in a Mouse Model of Colorectal Cancer

2012 ◽  
Vol 13 (8) ◽  
pp. 9419-9430 ◽  
Author(s):  
Lihui Wei ◽  
Jiumao Lin ◽  
Wei Xu ◽  
Qiaoyan Cai ◽  
Aling Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Tumor Angiogenesis ◽  
Hedgehog Pathway ◽  
Scutellaria Barbata

scholarly journals Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways

2013 ◽  
Vol 30 (4) ◽  
pp. 1701-1706 ◽  
Author(s):  
ALING SHEN ◽  
JIUMAO LIN ◽  
YOUQIN CHEN ◽  
WEI LIN ◽  
LIYA LIU ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Tumor Angiogenesis ◽  
Pien Tze Huang ◽  
Cellular Pathways

RPS24c Isoform Facilitates Tumor Angiogenesis Via Promoting the Stability of MVIH in Colorectal Cancer

2020 ◽  
Vol 20 (5) ◽  
pp. 388-395 ◽  
Author(s):  
Yue Wang ◽  
Youjun Wu ◽  
Kun Xiao ◽  
Yingjie Zhao ◽  
Gang Lv ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ribosomal Protein ◽  
Real Time ◽  
Tumor Angiogenesis ◽  
Real Time Pcr ◽  
Molecular Mechanisms ◽  
Migration And Invasion ◽  
Binding Interaction ◽  
Tubule Formation ◽  
The Stability

Background: Colorectal cancer (CRC) is the second leading cause of death worldwide, and distant metastasis is responsible for the poor prognosis in patients with advanced-stage CRC. RPS24 (ribosomal protein S24) as a ribosomal protein, multiple transcript variant encoding different isoforms have been found for this gene. Our previous studies have demonstrated that RPS24 is overexpressed in CRC. However, the mechanisms underlying the role of RPS24 in tumor development have not been fully defined. Methods: Expression of RPS24 isoforms and lncRNA MVIH in CRC tissues and cell lines were quantified by real-time PCR or western blotting assay. Endothelial tube formation assay was performed to determine the effect of RPS24 on tumor angiogenesis. The cell viability of HUVEC was determined by MTT assay, and the migration and invasion ability of HUVEC were detected by transwell assay. PGK1 secretion was tested with a specific ELISA kit. Results: Here, we found that RPS24c isoform was a major contributor to tumor angiogenesis, a vital process in tumor growth and metastasis. Real-time PCR revealed that RPS24c isoform was highly expressed in CRC tissues, while other isoforms are present in both normal and CRC tissues with no statistical difference. Moreover the change of RPS24 protein level is mainly due to the fluctuation of RPS24c. Furthermore, we observed that silencing RPS24c could decrease angiogenesis by inhibiting tubule formation, HUVEC cell proliferation and migration. Additionally, we investigated the molecular mechanisms and demonstrated that RPS24c mRNA interacted with lncRNA MVIH, the binding-interaction enhanced the stability of each other, thereby activated angiogenesis by inhibiting the secretion of PGK1. Conclusion: RPS24c facilitates tumor angiogenesis via the RPS24c/MVIH/PGK1 pathway in CRC. RPS24c inhibition may be a novel option for anti-vascular treatment in CRC.

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer

2021 ◽  
pp. 1-10
Author(s):  
Suzanne Mashtoub ◽  
Lauren C. Chartier ◽  
Debbie Trinder ◽  
Ian C. Lawrance ◽  
Gordon S. Howarth
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Disease Severity ◽  
Emu Oil

S2054 A Novel Mouse Model of Sporadic Colorectal Cancer

2008 ◽  
Vol 134 (4) ◽  
pp. A-305-A-306
Author(s):  
Kenneth Hung ◽  
Larissa Georgeon Richard ◽  
Alexandra Kunin ◽  
Umar Mahmood ◽  
Raju Kucherlapati
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Sporadic Colorectal Cancer

566: Investigating PI3Kinase and K-ras pathway interactions in mouse model of colorectal cancer

2014 ◽  
Vol 50 ◽  
pp. S136
Author(s):  
V. Meniel ◽  
I. Martin-Berenjeno ◽  
B. Vanhaesebroeck ◽  
A.R. Clarke
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Ras Pathway
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