scholarly journals Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil

2008 ◽  
Vol 122 (9) ◽  
pp. 2148-2153 ◽  
Author(s):  
Takako Eguchi Nakajima ◽  
Masahiro Yasunaga ◽  
Yasuhiko Kano ◽  
Fumiaki Koizumi ◽  
Ken Kato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Mouse Model ◽  
Polymeric Micelles ◽  
The Novel ◽  
Synergistic Antitumor Activity

scholarly journals Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1 in a mouse model of non-small cell lung cancer

2010 ◽  
Vol 127 (11) ◽  
pp. 2699-2706 ◽  
Author(s):  
Tatsuya Nagano ◽  
Masahiro Yasunaga ◽  
Koichi Goto ◽  
Hirotsugu Kenmotsu ◽  
Yoshikatsu Koga ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Antitumor Activity ◽  
Mouse Model ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Polymeric Micelles ◽  
Small Cell ◽  
Small Cell Lung ◽  
Synergistic Antitumor Activity

Synergistic antitumor activity of the SN-38-incorporating polymeric micelles NK012 with S-1.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e13588-e13588
Author(s):  
T. Nagano ◽  
M. Yasunaga ◽  
K. Goto ◽  
H. Kenmotsu ◽  
Y. Koga ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Polymeric Micelles ◽  
Synergistic Antitumor Activity

Synergistic antitumor activity of regorafenib and lapatinib in preclinical models of human colorectal cancer

2017 ◽  
Vol 386 ◽  
pp. 100-109 ◽  
Author(s):  
Wen-Ji Zhang ◽  
Yong Li ◽  
Meng-Ning Wei ◽  
Yao Chen ◽  
Jian-Ge Qiu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Human Colorectal Cancer ◽  
Preclinical Models ◽  
Synergistic Antitumor Activity

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

2019 ◽  
Vol 14 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Batool Hashemi-Beni ◽  
Mohsen Minaiyan ◽  
Saeedeh Enteshari
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tissue Distribution ◽  
Tumor Cells ◽  
Maleic Acid ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Background: Due to the low water solubility of Docetaxel (DTX), it is formulated with ethanol and Tween 80 with lots of side effects. For this reason, special attention has been paid to formulate it in new drug nano-carriers. Objective: The goal of this study was to evaluate the safety, antitumor activity and tissue distribution of the novel synthesized Raloxifene (RA) targeted polymeric micelles. Methods: DTX-loaded RA-targeted polymeric micelles composed of poly(styrene-maleic acid)- poly(amide-ether-ester-imide)-poly(ethylene glycol) (SMA-PAEE-PEG) were prepared and their antitumor activity was studied in MC4-L2 tumor-bearing mice compared with non-targeted micelles and free DTX. Safety of the micelles was studied by Hematoxylin and Eosin (H&E) staining of tumors and major organs of the mice. The drug accumulation in the tumor and major organs was measured by HPLC method. Results: The results showed better tumor growth inhibition and increased survival of mice treated with DTX-loaded in targeted micelles compared to the non-targeted micelles and free DTX. Histopathological studies, H&E staining of tumors and immunohistochemical examination showed the potential of DTX-loaded RA-targeted micelles to inhibit tumor cells proliferation. The higher accumulation of the DTX in the tumor tissue after injection of the micelles compared to the free DTX may indicate the higher uptake of the targeted micelles by the G-Protein-Coupled Estrogen Receptors (GPER). Conclusion: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of the drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX.

scholarly journals Cytocompatibility of stabilized black phosphorus nanosheets tailored by directly conjugated polymeric micelles for human breast cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
M. Biedulska ◽  
P. Jakóbczyk ◽  
M. Sosnowska ◽  
B. Dec ◽  
A. Muchlińska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Polymeric Micelles ◽  
Black Phosphorus ◽  
Environmental Stability ◽  
Breast Cancer Cell Lines ◽  
The Novel ◽  
Ft Ir ◽  
Dose Dependent ◽  
Aggressive Breast Cancer

AbstractThe novel procedure of few-layer black phosphorus (FLBP) stabilization and functionalisation was here proposed. The cationic polymer PLL and non-ionic PEG have been involved into encapsulation of FLBP to allow sufficient time for further nanofabrication process and overcome environmental degradation. Two different spacer chemistry was designed to bind polymers to tumor-homing peptides. The efficiency of functionalisation was examined by RP-HPLC, microscopic (TEM and SEM) and spectroscopic (FT-IR and Raman) techniques as well supported by ab-initio modelling. The cell and dose dependent cytotoxicity of FLBP and its bioconjugates was evaluated against HB2, MCF-7 and MDA-MB-231 cell lines. Functionalisation allowed not only for improvement of environmental stability, but also enhances therapeutic effect by abolished the cytotoxicity of FLBP against HB2 cell line. Moreover, modification of FLBP with PLL caused increase of selectivity against highly aggressive breast cancer cell lines. Results indicate the future prospect application of black phosphorus nanosheets as nanocarrier, considering its unique features synergistically with conjugated polymeric micelles.

Emu Oil Attenuates Disease Severity and Results in Fewer Large Colonic Tumors in a Mouse Model of Colitis-Associated Colorectal Cancer

2021 ◽  
pp. 1-10
Author(s):  
Suzanne Mashtoub ◽  
Lauren C. Chartier ◽  
Debbie Trinder ◽  
Ian C. Lawrance ◽  
Gordon S. Howarth
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Disease Severity ◽  
Emu Oil
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