scholarly journals Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(L-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

2011 ◽  
Vol 12 (2) ◽  
pp. 1371-1388 ◽  
Author(s):  
Chunhua Fu ◽  
Xiaoli Sun ◽  
Donghua Liu ◽  
Zhijing Chen ◽  
Zaijun Lu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Viral Vector ◽  
Gene Transfection ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Copolymer Poly

Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19484-19492 ◽  
Author(s):  
Junjie Li ◽  
Shuangzhuang Guo ◽  
Min Wang ◽  
Lei Ye ◽  
Fanglian Yao
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene

The syntheses, structures, and drug release behavior of shell or core cross-linked poly(lactic acid)/poly(ethylene glycol) block copolymer micelles.

Development of a gene carrier using a triblock co-polyelectrolyte with poly(ethylene imine)-poly(lactic acid)-poly(ethylene glycol)

2016 ◽  
Vol 32 (3) ◽  
pp. 280-292 ◽  
Author(s):  
Taehoon Sim ◽  
Gayoung Park ◽  
Hyeyoung Min ◽  
Soowon Kang ◽  
Chaemin Lim ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Viral Vector ◽  
Gene Carrier ◽  
Poly Lactic Acid ◽  
Stable Complex ◽  
Poly Ethylene Glycol ◽  
Small Interference Rna ◽  
Poly Ethylene ◽  
Interference Rna

The success of gene therapy mainly depends on the carriers for effective gene delivery. A non-viral vector using a cationic block co-polyelectrolyte, PEI-PLA-PEG polyethyleneimine-poly(lactic acid)-poly(ethylene glycol)) was developed as a potential gene carrier. The cationic PEI-PLA-PEG showed less toxicity compared to PEI and formed a gene nanocomplex (termed polyplex) by interaction with plasmid DNA or small interference RNA. The polyplex showed smaller particle size and greater positive zeta potential by increasing the high polymer nitrogen/DNA phosphate ratio. The polyplex with a nitrogen/DNA phosphate ratio of 16 or 32 demonstrated higher gene transfection by fluorescence imaging, flow cytometry measurement, and β-galactosidase activity. In particular, the polyplex with therapeutic histone deacetylase small interference RNA at nitrogen/DNA phosphate ratio 16 showed the most favorable properties with definite tumor growth inhibition. The synthetic PEI-PLA-PEG also showed less toxicity and would, therefore, be a great potential gene carrier, particularly given that small interference RNA delivery does not increase the charge density of small interference RNA due to the formation of a stable complex through conjugation with PLA-PEG.

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene

scholarly journals Local Toxicity of Topically Administrated Thermoresponsive Systems: In Vitro Studies with In Vivo Correlation

2018 ◽  
Vol 47 (3) ◽  
pp. 426-432 ◽  
Author(s):  
Sivan Yogev ◽  
Ayelet Shabtay-Orbach ◽  
Abraham Nyska ◽  
Boaz Mizrahi
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Medical Devices ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymers ◽  
Wide Range ◽  
Poly Ethylene

Thermoresponsive materials have the ability to respond to a small change in temperature—a property that makes them useful in a wide range of applications and medical devices. Although very promising, there is only little conclusive data about the cytotoxicity and tissue toxicity of these materials. This work studied the biocompatibility of three Food and Drug Administration approved thermoresponsive polymers: poly( N-isopropyl acrylamide), poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer, and poly(lactic acid-co-glycolic acid) and poly(ethylene glycol) tri-block copolymer. Fibroblast NIH 3T3 and HaCaT keratinocyte cells were used for the cytotoxicity testing and a mouse model for the in vivo evaluation. In vivo results generally showed similar trends as the results seen in vitro, with all tested materials presenting a satisfactory biocompatibility in vivo. pNIPAM, however, showed the highest toxicity both in vitro and in vivo, which was explained by the release of harmful monomers and impurities. More data focusing on the biocompatibility of novel thermoresponsive biomaterials will facilitate the use of existing and future medical devices.

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