scholarly journals Family Dysfunction Differentially Affects Alcohol and Methamphetamine Dependence: A View from the Addiction Severity Index in Japan

2011 ◽  
Vol 8 (10) ◽  
pp. 3922-3937 ◽  
Author(s):  
Nagisa Sugaya ◽  
Ayako Haraguchi ◽  
Yasukazu Ogai ◽  
Eiichi Senoo ◽  
Susumu Higuchi ◽  
...  
2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Farzaneh Karami ◽  
Fateme Assarian ◽  
Fatemeh Sadat Ghoreishi ◽  
Mojtaba Sehat

Background: Methamphetamine dependence is a growing global problem. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. One of the alternatives to manage this addiction is the use of N acetylcysteine (NAC) due to its capacity to restore homeostasis in the brain glutamate systems disrupted in addiction and its ability to reduce craving and the risk of relapse. Methods: Methamphetamine‐dependent volunteers under methadone treatment (n = 38) were randomized to receive daily doses of 1200 mg of NAC, or placebo. The participants were followed for 12 weeks (two visits weekly). Craving and Beck Inventory Depression (BDI) was determined at the beginning of the study and also after one month, two months, and three months. Addiction severity index (ASI) was recorded at the beginning of the study and after three months. The data were analyzed via SPSS version 16.0 (SPSS Inc. Chicago, Illinios, USA) Results: The mean score of craving and BDI reduced after two months with NAC treatment. ASI (e.g., substance, familial, and psychiatric categories) was significantly reduced at the end of the study in the NAC group compared to placebo (P < 0.001). The success of the treatment in groups of NAC and placebo were 84% and 73%, respectively (P = 0.001). 63.2% of the NAC group patients avoided substance use for more than a month, but this was 10.5% in the placebo group (P = 0.001). Conclusions: The NAC showed good efficacy in suppressing methamphetamine craving, addiction severity index, and depression. It may be a useful pharmacological treatment for methamphetamine dependency.


1991 ◽  
Author(s):  
Yifrah Kaminer ◽  
Oscar Bukstein ◽  
Ralph E. Tarter

2006 ◽  
Vol 31 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Samuel H. Rikoon ◽  
John S. Cacciola ◽  
Deni Carise ◽  
Arthur I. Alterman ◽  
A. Thomas McLellan

BJPsych Open ◽  
2018 ◽  
Vol 4 (6) ◽  
pp. 471-477 ◽  
Author(s):  
Angelina Isabella Mellentin ◽  
Annette Elkjær Ellermann ◽  
Bent Nielsen ◽  
Anna Mejldal ◽  
Sören Möller ◽  
...  

BackgroundDespite expansive knowledge on the detrimental effects of growing up with parents with alcohol use disorders (AUDs), little is known about the prognosis of alcohol treatment among parents with childcare responsibility.AimsThis observational cohort study aimed to examine the prognosis of patients with and without childcare responsibility, in a conventional out-patient alcohol treatment clinic.MethodA consecutive AUD sample (N = 2201), based on ICD-10 Diagnostic Criteria for Research, was assessed with the European Addiction Severity Index during the clinical routine, at treatment entry and conclusion. Data on addiction severity, treatment course and drinking outcomes were derived, and adjusted odds ratios (AORs) were calculated with logistic-regression models. Drinking outcomes were compared in an intention-to-treat analysis, including all patients in a logistic regression with inverse probability weighting.ResultsPatients with childcare responsibility (aged <18 years) had a less severe addiction profile and lower drop-out rate compared with patients without children or with children living out-of-home. They were also more likely to improve on all drinking-related outcomes, including abstinence (AOR 2.68, 95% CI 1.82–3.95), number of drinking days (AOR 2.45, 95% CI 1.50–4.03) and excessive drinking days (AOR 4.66, 95% CI 2.36–9.17); and those with children living out-of-home had better outcomes on abstinence (AOR 1.59, 95% CI 1.08–2.34) than patients without children.ConclusionsChildcare responsibility among out-patients was associated with better treatment course and outcomes than those without or not living with their children. This knowledge can help guide clinical practice, effectuate interventions and inform social authorities.


2004 ◽  
Vol 9 (3-4) ◽  
pp. 185-191 ◽  
Author(s):  
József Gerevich ◽  
Erika Bácskai ◽  
Sándor Rózsa

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