scholarly journals Glycaemic Variability and Risk Factors of Pregnant Women with and without Gestational Diabetes Mellitus Measured by Continuous Glucose Monitoring

2021 ◽  
Vol 18 (7) ◽  
pp. 3402
Author(s):  
Martina Gáborová ◽  
Viera Doničová ◽  
Ivana Bačová ◽  
Mária Pallayová ◽  
Martin Bona ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Glycaemic Control ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Target Range ◽  
Glycaemic Variability

Background: The aim of the study was to compare the continuous glucose monitoring (CGM)-determined glycaemic variability (GV) of pregnant women with gestational diabetes mellitus (GDM) and without GDM (CG; control group). The secondary aim was to evaluate the association between risk factors of diabetes in pregnancy and parameters of glyceamic control. Methods: Demographic, biometric and biochemical parameters were obtained for pregnant women (20–38 years old) who after an oral glucose tolerance test were examined by 7-day continuous glucose monitoring using a iPro®2 Professional CGM. Results: The differences in GV between women with GDM and CG compared by total area under glucose curve (total AUC, (mmol·day/L) was statistically significant (p = 0.006). Other parameters of glycaemic control such as mean glucose, standard deviation, coefficient of variation, J-index, % time-above target range 7.8 mmol/L (%TAR), % time-in range 3.5–7.8 mmol/L (%TIR), time-below target range 3.5 mmol/L (%TBR), glycated haemoglobin were not significantly different in the study groups. Risk factors (a family history of diabetes, pre-pregnancy BMI, higher weight gain and age) correlated with parameters of glycaemic control. Conclusions: We found a significant difference in GV of women with and without GDM by total AUC determined from CGM. TIR metrics were close to significance. Our work points at an increased GV in relation to the risk factors of GDM. Pregnant women with risk factors have higher probability of severe GV with its consequences on maternal and fetal health state.

Continuous Glucose Monitoring and Glycemic Patterns in Pregnant Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 22 (4) ◽  
pp. 271-277
Author(s):  
Rosa Márquez-Pardo ◽  
Isabel Torres-Barea ◽  
Juan-Antonio Córdoba-Doña ◽  
Concepcion Cruzado-Begines ◽  
Lourdes García-García-Doncel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring

scholarly journals Continuous glucose monitoring during pregnancy in healthy mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Caroline Wuyts ◽  
Caroline Simoens ◽  
Silvia Pinto ◽  
Koenraad Philippaert ◽  
Rudi Vennekens
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
The Body ◽  
Complete Analysis ◽  
Glycaemic Variability ◽  
Metabolic Adaptations ◽  
Freely Moving

AbstractDuring pregnancy, metabolic adaptations occur to maintain the balance between maternal and foetal growth, including increased insulin secretion and decreased insulin sensitivity. When the body fails to adjust, gestational diabetes mellitus develops. To gain insight in the pregnancy-induced adaptations, we applied continuous glucose monitoring via telemetric transmitters. We show that continuous glucose monitoring in conscious, non-stressed, freely moving mice throughout the full pregnancy is feasible, accurate and safe. We show that healthy mice during a full pregnancy develop adaptations in glucose homeostasis reminiscent of those in pregnant women. Furthermore, continuous glucose monitoring allows the complete analysis of all aspects of glucose excursions associated with spontaneous feeding episodes, and the thorough analysis of glycaemic variability. In conclusion, continuous glucose monitoring allows a detailed description of the glycaemic status during pregnancy, which will help to unravel specific mechanisms for gestational diabetes mellitus.

scholarly journals Most frequent problems of pregnant women with gestational diabetes mellitus

2016 ◽  
Vol 126 (3) ◽  
pp. 107-111 ◽  
Author(s):  
Grażyna J. Iwanowicz-Palus ◽  
Marta Zarajczyk ◽  
Aleksandra Jakubowska ◽  
Agnieszka Bień ◽  
Ewa Rzońca
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Rural Areas ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring ◽  
Professional Activity ◽  
Psychological Burden ◽  
Socio Demographic Factors

Abstract Introduction. Gestational diabetes mellitus (GDM) is the most common metabolic disorder happening to pregnant women. Some. 3-5% of all pregnant women in Poland are diagnosed with the condition. Glucose tolerance disorders or gestational diabetes recur in about 30% of women during their second (or next) pregnancy. Controlling diabetes involves many new responsibilities and sacrifices that may be difficult to bear for a pregnant woman. Aim. The aim of the present study was to examine the most common problems among pregnant women with gestational diabetes Material and methods. The study was conducted between 2015 and 2016. The authors used a diagnostic survey on 120 pregnant women with diabetes who were patients in gestational pathology and conservative gynecological treatment departments and diabetic outpatient clinics in Lublin. The χ2 test of independence was used to examine correlations between socio-demographic factors and problems experienced by pregnant women with gestational diabetes. Results. Problems with keeping a blood glucose monitoring diary were reported by women from cities different than province capitals (75%). Childless women reported problems with pricking their finger multiple times a day (60%). Insulin injections were perceived as a GDM-related problem mostly by women aged 31-35 (41.2%), women in their second pregnancy (61.8%) and women with more than one child (47.1%). Frequent visits to the doctor were perceived as a problem mostly by women aged less than 26 (42.3%), women living in rural areas (57.7%), women with higher education (84.6%), women in their first pregnancy (61.5%) and women without children (73.1%). The two last groups additionally indicated psychological burden (84.2% and 78.9%, respectively). Anxiety about the occurrence of type 2 diabetes was mainly expressed by women aged 26-30 (35.3%) and those in their second pregnancy (52.9%), whilst working women expressed concern for their own lives (78.6%). Conclusions. There is a correlation between selected problems experienced by pregnant women with GDM and socio-demographic variables such as: age, place of residence, education, professional activity and number of pregnancies and children. The results obtained suggest that there is a need for educating women about the most frequent problems that accompany pregnancy with GDM.

Continuous Glucose Monitoring During Breastfeeding in Women with Recent Gestational Diabetes Mellitus

2012 ◽  
Vol 14 (7) ◽  
pp. 576-582 ◽  
Author(s):  
Antonietta Colatrella ◽  
Marialuisa Framarino ◽  
Vincenzo Toscano ◽  
Marzia Bongiovanni ◽  
Camilla Festa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring

scholarly journals Risk Factors for the Requirement of Antenatal Insulin Treatment in Gestational Diabetes Mellitus

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Mayu Watanabe ◽  
Akihiro Katayama ◽  
Hidetoshi Kagawa ◽  
Daisuke Ogawa ◽  
Jun Wada
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Therapy ◽  
Pregnant Women ◽  
Plasma Glucose ◽  
Insulin Treatment ◽  
Diet Group ◽  
Glucose Levels

Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group;n=10) and without insulin therapy (Diet group;n=27). The 1-h and 2-h plasma glucose levels and the number of abnormal values in 75 g OGTT were significantly higher in AIT group compared with Diet group. By logistic regression analysis, plasma glucose level at 1-h was significant predictor for AIT and the odds ratios were 1.115 (1.004–1.239) using forward selection method and 1.192 (1.006–1.413) using backward elimination method. There were no significant differences in obstetrical outcomes and neonatal complications. 1-h plasma glucose levels in 75 g OGTT are useful parameters in predicting the requirement for AIT in GDM. Both maternal and neonatal complications are comparable in GDM patients with and without insulin therapy.

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