scholarly journals Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (1) ◽  
pp. 140 ◽  
Author(s):  
Yubo Liu ◽  
Weibing Ye ◽  
Qian Chen ◽  
Yong Zhang ◽  
Chia-Hua Kuo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Blood Glucose ◽  
Resistance Exercise ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Meta Regression ◽  
Meta Regression Analysis

We investigated the influence of resistance exercise (RE) with different intensities on HbA1c, insulin and blood glucose levels in patients with type 2 diabetes (T2D). Diabetes trials that compared RE group with a control were included in meta-analysis. Exercise intensities were categorized into low-to-moderate-intensity and high-intensity subgroups. Intensity effect on glycemic control was determined by meta-regression analysis, and risk-of-bias was assessed using Cochrane Collaboration tool. 24 trials met the inclusion criteria, comprised of 962 patients of exercise (n = 491) and control (n = 471). Meta-regression analysis showed decreased HbA1c (p = 0.006) and insulin (p = 0.015) after RE was correlated with intensity. Subgroup analysis revealed decreased HbA1c was greater with high intensity (−0.61; 95% CI −0.90, −0.33) than low-to-moderate intensity (−0.23; 95% CI −0.41, −0.05). Insulin levels were significantly decreased only with high intensity (−4.60; 95% CI −7.53, −1.67), not with low-to-moderate intensity (0.07; 95% CI −3.28, 3.42). Notably, values between the subgroups were statistically significant for both HbA1c (p = 0.03) and insulin (p = 0.04), indicative of profound benefits of high-intensity RE. Pooled outcomes of 15 trials showed only a decreased trend in blood glucose with RE (p = 0.09), and this tendency was not associated with intensity. Our meta-analysis provides additional evidence that high-intensity RE has greater beneficial effects than low-to-moderate-intensity in attenuation of HbA1c and insulin in T2D patients.

scholarly journals Low-to-Moderate-Intensity Resistance Exercise Effectively Improves Arterial Stiffness in Adults: Evidence From Systematic Review, Meta-Analysis, and Meta-Regression Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Yong Zhang ◽  
Ya-Jun Zhang ◽  
Weibing Ye ◽  
Mallikarjuna Korivi
Keyword(s):  
Systematic Review ◽  
Arterial Stiffness ◽  
Resistance Exercise ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Cochrane Library ◽  
Middle Aged ◽  
Meta Regression ◽  
Middle Aged Adults

Background/Purpose: Resistance exercise (RE) is known to improve cardiovascular health, but the role of RE variables on arterial stiffness is inconclusive. In this systematic review and meta-analysis, we investigated the influence of RE and its intensities on arterial stiffness measured as pulse wave velocity (PWV) in young and middle-aged adults.Methods: Web of Science, PubMed/MEDLINE, Scopus, EMBASE, Cochrane Library, ScienceDirect, CINAHL, Wiley Online Library, and Google Scholar were searched for relevant studies. RE trials that reported PWV data, and compared with respective controls were included. The Cochrane Collaboration tool was used to assess the risk of bias.Results: Data were synthesized from a total of 20 studies, involving 981 participants from control (n = 462) and exercise (n = 519) trials. The test for overall effect (pooled outcome) showed RE intervention had no effect on arterial stiffness (SMD = −0.09; 95% CI: −0.32, 0.13; P = 0.42), but risk of heterogeneity (I2) was 64%. Meta-regression results revealed a significant correlation (P = 0.042) between RE intensity and PWV changes. Consequently, the trials were subgrouped into high-intensity and low-to-moderate-intensity to identify the effective RE intensity. Subgroup analysis showed that low-to-moderate-intensity significantly decreased PWV (SMD = −0.34; 95% CI: −0.51, −0.17; P < 0.0001), while high-intensity had no effect (SMD = 0.24; 95% CI: −0.18, 0.67; P = 0.26). When trials separated into young and middle-aged, low-to-moderate-intensity notably decreased PWV in young (SMD = −0.41; 95% CI: −0.77, −0.04; P = 0.03) and middle-aged adults (SMD = −0.32; 95% CI: −0.51, −0.14; P = 0.0007), whereas high-intensity had no effect in both age groups.Conclusions: Our findings demonstrated that RE intensity is the key variable in improving arterial stiffness. Low-to-moderate-intensity can prescribe as an effective non-pharmacological strategy to treat cardiovascular complications in young and middle-aged adults.

2185-PUB: Once-Weekly Semaglutide 1mg vs. Empagliflozin 25mg as Add-On to Metformin Monotherapy in Patients with Type 2 Diabetes: A Meta-regression Analysis of Individual Patient Data

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2185-PUB
Author(s):  
ILDIKO LINGVAY ◽  
ANDREI-MIRCEA CATARIG ◽  
ANNA SANDBERG ◽  
JACK LAWSON ◽  
MATTHEW CAPEHORN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Individual Patient Data ◽  
Patient Data ◽  
Metformin Monotherapy ◽  
Meta Regression ◽  
Meta Regression Analysis
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