Effectiveness of Digital Interventions for Improving Glycemic Control in Persons with Poorly Controlled Type 2 Diabetes—A Systematic Review and Meta-regression Analysis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 840-P ◽  
Author(s):  
MIHIRETU M. KEBEDE ◽  
HAJO ZEEB ◽  
MANUELA PETERS ◽  
THOMAS L. HEISE ◽  
CLAUDIA R. PISCHKE
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Glycemic Control ◽  
Digital Interventions ◽  
Meta Regression ◽  
Meta Regression Analysis

2185-PUB: Once-Weekly Semaglutide 1mg vs. Empagliflozin 25mg as Add-On to Metformin Monotherapy in Patients with Type 2 Diabetes: A Meta-regression Analysis of Individual Patient Data

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2185-PUB
Author(s):  
ILDIKO LINGVAY ◽  
ANDREI-MIRCEA CATARIG ◽  
ANNA SANDBERG ◽  
JACK LAWSON ◽  
MATTHEW CAPEHORN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Individual Patient Data ◽  
Patient Data ◽  
Metformin Monotherapy ◽  
Meta Regression ◽  
Meta Regression Analysis

scholarly journals Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (1) ◽  
pp. 140 ◽  
Author(s):  
Yubo Liu ◽  
Weibing Ye ◽  
Qian Chen ◽  
Yong Zhang ◽  
Chia-Hua Kuo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Regression Analysis ◽  
Blood Glucose ◽  
Resistance Exercise ◽  
High Intensity ◽  
Meta Analysis ◽  
Moderate Intensity ◽  
Meta Regression ◽  
Meta Regression Analysis

We investigated the influence of resistance exercise (RE) with different intensities on HbA1c, insulin and blood glucose levels in patients with type 2 diabetes (T2D). Diabetes trials that compared RE group with a control were included in meta-analysis. Exercise intensities were categorized into low-to-moderate-intensity and high-intensity subgroups. Intensity effect on glycemic control was determined by meta-regression analysis, and risk-of-bias was assessed using Cochrane Collaboration tool. 24 trials met the inclusion criteria, comprised of 962 patients of exercise (n = 491) and control (n = 471). Meta-regression analysis showed decreased HbA1c (p = 0.006) and insulin (p = 0.015) after RE was correlated with intensity. Subgroup analysis revealed decreased HbA1c was greater with high intensity (−0.61; 95% CI −0.90, −0.33) than low-to-moderate intensity (−0.23; 95% CI −0.41, −0.05). Insulin levels were significantly decreased only with high intensity (−4.60; 95% CI −7.53, −1.67), not with low-to-moderate intensity (0.07; 95% CI −3.28, 3.42). Notably, values between the subgroups were statistically significant for both HbA1c (p = 0.03) and insulin (p = 0.04), indicative of profound benefits of high-intensity RE. Pooled outcomes of 15 trials showed only a decreased trend in blood glucose with RE (p = 0.09), and this tendency was not associated with intensity. Our meta-analysis provides additional evidence that high-intensity RE has greater beneficial effects than low-to-moderate-intensity in attenuation of HbA1c and insulin in T2D patients.

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