scholarly journals Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging

Geriatrics ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 16 ◽  
Author(s):  
Simone Perna ◽  
Tariq A. Alalwan ◽  
Salwa Al-Thawadi ◽  
Massimo Negro ◽  
Mauro Parimbelli ◽  
...  
Keyword(s):  
Musculoskeletal Disorders ◽  
Observational Studies ◽  
Free Form ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Pharmacological Interventions ◽  
Cross Sectional ◽  
Randomized Controlled ◽  
Dietary Counselling

Musculoskeletal disorders in aging and pain are closely connected because of multiple mechanisms leading to loss of mobility and autonomy. Pain is predictive of diability and worsening frailty and the strength of this relationship increases with the severity of pain. This study presents a systematic review of randomized controlled trials, cross sectional studies, and observational studies based on treatment of pain in adults with musculoskeletal disorders using nutritional non-pharmacological (nutrients and antioxidants) interventions. The review found the efficiency of the following topics: (a) accession of the patient to a dietary counselling (e.g., daily recommended amount of protein—equivalent to at least of 1 g of protein per kilogram of body weight); (b) intake of glutamic acid-rich such as soy, egg, and cod and tryptophan-rich foods such as milk and peanuts—or taking quick-acting, free-form supplements; (c) supplementation of vitamin D and magnesium, if lacking; (d) weekly consumption of fish or supplements of omega-3 fatty acids; and (e) availability of botanicals, in particular curcumin and gingerol. These non-pharmacological interventions can help the pain therapist to create a personalized medicine (precision medicine), acting with the maximum efficacy and safety, and also reducing the dosage of analgesic drugs needed.

scholarly journals Effects of Some Common Food Constituents on Cardiovascular Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Yaling Yang ◽  
Sze Wa Chan ◽  
Miao Hu ◽  
Richard Walden ◽  
Brian Tomlinson
Keyword(s):  
Observational Studies ◽  
Red Wine ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Myocardial Infraction ◽  
All Cause Mortality ◽  
Potential Benefits ◽  
Cocoa Tea

Cardiovascular diseases are the major cause of morbidity and mortality worldwide, and there is considerable interest in the role of dietary constituents and supplements in the prevention and treatment of these disorders. We reviewed the major publications related to potential effects on cardiovascular risk factors and outcomes of some common dietary constituents: carotenoids, flavonoid-rich cocoa, tea, red wine and grapes, coffee, omega-3 fatty acids, and garlic. Increased intake of some of these has been associated with reduced all-cause mortality or reduced incidence of myocardial infraction, stroke, and hypertension. However, although the evidence from observational studies is supportive of beneficial effects for most of these foodstuffs taken as part of the diet, potential benefits from the use of supplements derived from these natural products remain largely inconclusive.

scholarly journals The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 2261-2273 ◽  
Author(s):  
Qiu Lei ◽  
Xin Wang ◽  
Xian Xia ◽  
Hua Zheng ◽  
Jing Bi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Pancreatitis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled

scholarly journals Role of omega 3-fatty acids and multivitamins in gestation

2007 ◽  
Vol 35 (s1) ◽  
pp. S19-S24 ◽  
Author(s):  
Irene Hösli ◽  
Rosanna Zanetti-Daellenbach ◽  
Wolfgang Holzgreve ◽  
Olav Lapaire
Keyword(s):  
Fatty Acids ◽  
Observational Studies ◽  
Meta Analysis ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Daily Diet ◽  
Pregnancy And Postpartum ◽  
Maternal Risks ◽  
Global Health Problem

AbstractThere is a rising interest in a balanced and varied women's diet not only preconceptionally but also during pregnancy and in the breastfeeding period in order to reduce fetal, neonatal, and maternal risks. A decreased intake of omega 3-fatty acids (FA) or deficiencies of micronutrients are a global health problem, not only in developing countries, where micronutrient-rich food and fortified aliments are often not available, and also in the industrialized world. In contrast to data about the daily periconceptionally intake of folate acid that has been shown to reduce substantially the occurrence and recurrence of neural tube defects (NTD), the benefit of other micronutrients is less determinant.Deficiencies of omega 3-FA may be a contributing factor for severe complications in pregnancy and postpartum. A meta-analysis for the role of omega 3-FA in preeclampsia and maternal postpartum depression is less consistent, some meta-view's results differ substantially or are even contradictory to large observational studies. Further well-designed studies are warranted. A personal interview and counseling concerning the daily diet should be integrated in the preconceptional and in the antenatal care and an individual supplementation should be offered, if indicated.

scholarly journals Omega-3 fatty acids in the treatment of acute lung injury: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Caijie Huang ◽  
Jianming Zheng ◽  
Wenzhao Huang ◽  
Meihao Yan ◽  
Liyue Hong ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Meta Analysis ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled ◽  
Mean Differences

Abstract Background Several randomized controlled trials (RCTs) have compared the treatment of acute lung injury (ALI) with or without omega-3 fatty acids, yet the results remained inconsistent. Therefore, we attempted this meta-analysis to analyze the role of T Omega-3 fatty acids in the treatment of ALI patients.Methods We searched PubMed et al databases from inception date to Oct 31, 2019 for RCTs that compared the treatment of ALI with or without omega-3 fatty acids. Two authors independently screened the studies and extracted data from the published articles. Summary mean differences (MD) with 95% confidence intervals (CI) were calculated for each outcome by means of fixed- or random-effects model.Results Six RCTs with a total of 277 patients were identified, with 142 with omega-3 fatty acids treatment and 135 without omega-3 fatty acids treatment. Omega-3 fatty acids treatments significantly improve the PaO2 (MD =13.82, 95%CI 8.55– 19.09), PaO2/FiO2 (MD =33.47, 95% CI 24.22– 42.72), total protein (MD =2.02, 95% CI 0.43– 3.62) in ALI patients; furthermore, Omega-3 fatty acids treatments reduced the duration of mechanical ventilation (MD =-1.72, 95% CI -2.84– -0.60) and intensive care unit stay (MD =-1.29, 95% CI -2.14– -0.43) in ALI patients.Conclusions Omega-3 fatty acids can effectively improve the respiratory function and promote the recovery of ALI patients. More studies focused on the long-term efficacy and safety of omega-3 fatty acids use for ALI are needed.

COVID-19 and nutritional deficiency: a review of existing knowledge

2021 ◽  
Vol 42 (1) ◽  
pp. 77-85
Author(s):  
Meghana Muthuvattur Pallath ◽  
Ashok Kumar Ahirwar ◽  
Satyendra Chandra Tripathi ◽  
Priyanka Asia ◽  
Apurva Sakarde ◽  
...  
Keyword(s):  
Immune Responses ◽  
Viral Infection ◽  
Close Contact ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Antibody Affinity ◽  
Global Pandemic ◽  
Underlying Diseases ◽  
Pro Inflammatory Cytokines

Abstract COVID-19 has resulted in an ongoing global pandemic, which spread largely among people who have had close contact with the infected person. The immunopathology of the SARS-CoV-2 virus includes the production of an excess amount of pro-inflammatory cytokines “a cytokine-storm”. The respiratory system (main), cardiovascular system and the gastrointestinal tract are the most affected body systems during viral infection. It has been found that most of the patients who require admission to hospital are elderly or have chronic underlying diseases. Higher cases of malnutrition and co-morbidities like diabetes mellitus and cardiovascular diseases are reported in elderly patients due to which, the immune system weakens and hence, the response to the virus is diminished in magnitude. A deficiency of micronutrients results in impaired immune responses leading to improper secretion of cytokines, alterations in secretory antibody response and antibody affinity which increases susceptibility to viral infection. The deficiency of various micronutrients in COVID-19 patient can be treated by appropriate nutritional supplements, prescribed after evaluating the patients’ nutritional status. Here we aim to highlight the role of a few particular nutrients namely Vitamin D, Vitamin C, Omega-3 fatty acids, Zinc and Magnesium along with the synergistic roles they play in enhancing immunity and thus, maintaining homeostasis.

Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

2014 ◽  
Vol 76 (7) ◽  
pp. 559-566 ◽  
Author(s):  
Kuan-Pin Su ◽  
Hsueh-Chou Lai ◽  
Hui-Ting Yang ◽  
Wen-Pang Su ◽  
Cheng-Yuan Peng ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Randomized Controlled Trial ◽  
Interferon Alpha ◽  
Controlled Trial ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled

Omega-3 Levels and Nicotine Dependence: A Cross-Sectional Study and Clinical Trial

2015 ◽  
Vol 22 (3) ◽  
pp. 153-162 ◽  
Author(s):  
Juçara X. Zaparoli ◽  
Eduardo K. Sugawara ◽  
Altay A.L. de Souza ◽  
Sérgio Tufik ◽  
José Carlos F. Galduróz
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Nicotine Dependence ◽  
Cross Sectional Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Cross Sectional ◽  
Omega 3 Fatty Acid

Background: High oxidative stress, which is caused by smoking, can alter omega-3 fatty acid concentrations. Since omega-3 fatty acids play a role in dopaminergic neurotransmission related to dependence, it is important to understand their effects on nicotine dependence. Methods: This research comprised 2 studies. The first one consisted of a cross-sectional evaluation, in which the levels of the most important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were compared between smokers and non-smokers in a sample of 171 individuals; of them, 120 were smokers and 51 were non-smokers. The other study was a clinical, double-blind, randomized, placebo controlled, in which 63 smokers received daily treatment with capsules of fish oil (a source of omega-3/3 g/day) or mineral oil (used as placebo, also 3 g/day), taken 3 times a day for 90 days. Each fish oil capsules contained approximately 210.99 mg EPA and 129.84 mg of DHA. The outcome was evaluated by means of psychometric and biological measures as well as self-reports of tobacco use. The evaluations were carried out at the beginning of treatment and once a month thereafter (total of 4 times). Outcomes: The omega-3 fatty acid lipid profile showed that smokers present lower concentrations of DHA. After treatment, the omega-3 group showed a significant reduction in their levels of dependence. Interpretation: Smokers showed lower peripheral levels of omega-3, and treatment with the most important omega-3 fatty acids brought about a reduction in nicotine dependence.

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