scholarly journals The Role of Omega-3 Fatty Acids in Acute Pancreatitis: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 2261-2273 ◽  
Author(s):  
Qiu Lei ◽  
Xin Wang ◽  
Xian Xia ◽  
Hua Zheng ◽  
Jing Bi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Acute Pancreatitis ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled

scholarly journals The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0228315 ◽  
Author(s):  
Api Chewcharat ◽  
Pol Chewcharat ◽  
Anawin Rutirapong ◽  
Stefania Papatheodorou
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled

Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials

2012 ◽  
Vol 221 (2) ◽  
pp. 536-543 ◽  
Author(s):  
Qianqian Wang ◽  
Xiaohua Liang ◽  
Laiyuan Wang ◽  
Xiangfeng Lu ◽  
Jianfeng Huang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Function ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled

Effect of Long-Term Marine Omega-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Circulation ◽  
2021 ◽  
Author(s):  
Baris Gencer ◽  
Luc Djousse ◽  
Omar T. Al-Ramady ◽  
Nancy R. Cook ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Fatty Acids ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Cardiovascular Outcomes ◽  
Controlled Trials ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Randomized Controlled ◽  
Increased Risk

Background: Some, but not all, large-scale randomized controlled trials (RCTs) investigating the effects of marine omega-3 fatty acids supplementation on cardiovascular outcomes have reported increased risks of atrial fibrillation (AF). The potential reasons for disparate findings may be dose related. Methods: The MEDLINE and Embase databases were searched for articles and abstracts published between January 1, 2012 and December 31, 2020 in addition to a meta-analysis of large cardiovascular RCTs published in 2019. RCTs of cardiovascular outcomes of marine omega-3 fatty acids that reported results for AF, either as pre-specified outcome, adverse event, or a cause for hospitalization, with a minimum sample size of 500 patients and a median followup of at least one year were included. RCTs specifically examining shorter term effects of omega-3 fatty acids on recurrent AF in patients with established AF or post-operative AF were not included. The hazard ratio (HR) for the reported AF outcomes within each trial was metaanalyzed using random-effects model with Knapp-Hartung adjustment and evaluated a doseresponse relationship with a meta-regression model. Results: Of 4049 screened records, seven studies were included in the meta-analysis. Of those, five were already detected in a previous meta-analysis of cardiovascular RCTs. Among the 81,210 patients from 7 trials, 58,939 (72.6%) were enrolled in trials testing ≤1gram per day (g/d) and 22,271 (27.4%) in trials testing >1g/d of omega-3 fatty acids. The mean age was 65 years and 31,842 (39%) were female. The weighted average follow-up was 4.9 years. In meta-analysis, the use of marine omega-3 fatty acid supplements was associated with an increased risk of AF (n=2,905; HR 1.25, 95%CI 1.07-1.46, P=0.013). In analyses stratified by dose, the HR was greater in the trials testing >1g/d (HR 1.49, 95%CI 1.04-2.15, P=0.042) as compared with those testing ≤1 g/d (HR 1.12, 95%CI 1.03-1.22, P=0.024, P for interaction<0.001). In metaregression, the HR for AF increased per 1 gr increase of omega-3 fatty acids dosage (HR 1.11, 95%CI 1.06-1.15, P=0.001). Conclusions: In RCTs examining cardiovascular outcomes, marine omega-3 supplementation was associated with an increased risk of AF. The risk appeared to be greater in trials testing >1g/d.

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