scholarly journals The Decisive Case-Control Study Elaborates the Null Association between ESR1 XbaI and Osteoarthritis in Asians: A Case–Control Study and Meta-Analysis

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 404
Author(s):  
Yu-Hao Huang ◽  
Wen-Hui Fang ◽  
Dung-Jang Tsai ◽  
Yu-Hsuan Chen ◽  
Yu-Chiao Wang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Gender Difference ◽  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Current Evidence ◽  
Trial Sequential Analysis ◽  
Knee Oa ◽  
Control Study

(1) Background: The prevalence of knee osteoarthritis (OA) in women is significantly higher than in men. The estrogen receptor α (ERα) has been considered to play a key role due to a large gender difference in its expression. ERα is encoded by the gene estrogen receptor 1 (ESR1), which is widely studied to explore the gender difference in knee OA. Several polymorphisms in ESR1 [PvuII (rs2234693) and BtgI (rs2228480)] were confirmed as the risk factors of OA. However, the evidence of the last widely investigated polymorphism, ESR1 Xbal (rs9340799), is still insufficient for concluding its effect on knee OA. (2) Objective: This study proposed a case–control study to investigate the association between ESR1 Xbal and knee OA. Moreover, a meta-analysis and trial sequential analysis (TSA) were conducted to enlarge the sample size for obtaining a conclusive evidence. (3) Methods: In total, 497 knee OA cases and 473 healthy controls were recruited between March 2015 and July 2018. The Kellgren–Lawrence grading system was used to identify the knee OA cases. To improve the evidence level of our study, we conducted a meta-analysis including the related studies published up until December 2018 from PubMed, Embase, and previous meta-analysis. The results are expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) for evaluating the effect of this polymorphism on knee OA risk. TSA was used to estimate the sample sizes required in this issue. (4) Results: We found non-significant association between the G allele and knee OA [Crude-OR: 0.97 (95% CI: 0.78–1.20) and adjusted-OR: 0.90 (95% CI: 0.71–1.15) in allele model] in the present case–control study, and the analysis of other genetic models showed a similar trend. After including six published studies and our case–control studies, the current evidence with 3174 Asians showed the conclusively null association between ESR1 XbaI and knee OA [OR: 0.78 (95% CI: 0.59–1.04)] with a high heterogeneity (I2: 78%). The result of Caucasians also concluded the null association [OR: 1.05 (95% CI: 0.56–1.95), I2: 87%]. (5) Conclusions: The association between ESR1 XbaI and knee OA was not similar with other polymorphisms in ESR1, which is not a causal relationship. This study integrated all current evidence to elaborate this conclusion for suggesting no necessity of future studies.

TNF-α-308A>G and IL-10-819C>T polymorphisms as risk factors for cervical cancer: A case-control study, meta-analysis and trial sequential analysis

Meta Gene ◽  
2021 ◽  
pp. 100943
Author(s):  
EdilsonLeite de Moura ◽  
Denise Macedo da Silva ◽  
Ana CarolineMelo dos Santos ◽  
Adriely Ferreira da Silva ◽  
Abel Barbosa Lira Neto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Trial Sequential Analysis ◽  
Tnf Α ◽  
Control Study

scholarly journals PPARG Pro12Ala Polymorphism with CKD in Asians: A Meta-Analysis Combined with a Case-Control Study—A Key for Reaching Null Association

Genes ◽  
2020 ◽  
Vol 11 (6) ◽  
pp. 705
Author(s):  
Hsiang-Cheng Chen ◽  
Wei-Teing Chen ◽  
Tzu-Ling Sung ◽  
Dung-Jang Tsai ◽  
Chin Lin ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Control Sample ◽  
Case Control ◽  
Trial Sequential Analysis ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Control Study

Background: So far, numerous meta-analyses have been published regarding the correlation between peroxisome proliferator-activated receptor gamma (PPARG) proline 12 alanine (Pro12Ala) gene polymorphism and chronic kidney disease (CKD); however, the results appear to be contradictory. Hence, this study is formulated with the objective of using existing meta-analysis data together with our research population to study the correlation between PPARG Pro12Ala gene polymorphism and CKD and evaluate whether an accurate result can be obtained. Methods: First, literature related to CKD and PPARG Pro12Ala available on the PubMed and EMBASE databases up to December 2016 was gathered from 20 publications. Then, the gathered results were combined with our case-control study of 1693 enrolled subjects and a trial sequential analysis (TSA) was performed to verify existing evidence and determine whether a firm conclusion can be drawn. Results: The TSA results showed that the cumulative sample size for the Asian sample was 6078 and was sufficient to support a definite result. The results of this study confirmed that there is no obvious correlation between PPARG Pro12Ala and CKD for Asians (OR = 0.82 (95% CI = 0.66–1.02), I2 = 63.1%), but this was not confirmed for Caucasians. Furthermore, the case-control sample in our study was shown to be the key for reaching this conclusion. Conclusions: The meta-analysis results of this study suggest no significant correlation between PPARG Pro12Ala gene polymorphism and CKD for Asians after adding our samples, but not for Caucasian.

Association of rs1801133 polymorphism with migraine susceptibility: A case-control study followed by updated meta-analysis and trial sequential analysis

Gene Reports ◽  
2020 ◽  
Vol 21 ◽  
pp. 100881
Author(s):  
P.S. Aiswarya ◽  
R.S. Akram Husain ◽  
Pallavi Kesavan ◽  
K. Subramaniyan ◽  
Shiek S.S.J. Ahmed ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Trial Sequential Analysis ◽  
Control Study

scholarly journals Lack of association between IGF2BP2 rs4402960 polymorphism and gestational diabetes mellitus: a case–control study, meta-analysis and trial sequential analysis

2020 ◽  
Vol 40 (7) ◽  
Author(s):  
Jing Liu ◽  
Guang Song ◽  
Ge Zhao ◽  
Tao Meng
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Sequential Analysis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Genetic Models ◽  
Trial Sequential Analysis ◽  
Control Study

Abstract Background: It is well known that insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs4402960 polymorphism is associated with Type 2 diabetes mellitus, which has a shared genetic background with gestational diabetes mellitus (GDM). Previous studies have yielded controversial results about the link between IGF2BP2 rs4402960 polymorphism and GDM risk. Thus, a meta-analysis was performed to obtain more conclusive results. Methods: Clinical and genotype data were determined for 305 GDM and 1216 healthy participants recruited. Eligible studies were retrieved in PubMed, Web of science, EMBASE, and Scopus. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between IGF2BP2 polymorphisms and GDM susceptibility in five genetic models. The subgroup stratified analysis and trial sequential analysis (TSA) were performed. Results: In this case–control study, no significant association was revealed between IGF2BP2 polymorphism and GDM (P>0.05). When combined with the previous studies in the meta-analysis, there was no statistical association between IGF2BP2 polymorphism and GDM (allele model: OR = 1.01, 95% CI = 0.86–1.18; dominant model: OR = 1.00, 95% CI = 0.81–1.24; recessive model: OR = 1.08, 95% CI = 0.91–1.29; heterozygous model: OR = 0.99, 95% CI = 0.80–1.24; homozygous model: OR = 1.06, 95% CI = 0.78–1.42). No association was observed in five genetic models in each subgroup. TSA indicated sufficient proof of such null association in the overall population. Conclusions: This meta-analysis provides sufficient statistical evidence indicating null association between IGF2BP2 rs4402960 polymorphism and GDM risk.

scholarly journals The Decisive Case-Control Study Elaborates the Null Association between ADAMTS5 rs226794 and Osteoarthritis in Asians: A Case-Control Study and Meta-Analysis

Genes ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1916
Author(s):  
Chung-Cheng Kao ◽  
Hsiang-En Hsu ◽  
Yi-Chou Chen ◽  
Ming-Yu Tu ◽  
Su-Wen Chuang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Meta Analysis ◽  
Gene Sequencing ◽  
Case Control ◽  
Knee Oa ◽  
The Relationship ◽  
Allele Model ◽  
Control Study

Background: Osteoarthritis is an important health issue for the elderly. Many studies indicate that genetics is an important risk factor for osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is one gene that is most frequently implicated. Many recent studies have examined the relationship between a polymorphism in the ADAMTS5 gene (rs226794) and the risk for developing osteoarthritis without definitive results. Objective: In this case-control study, we examined the correlation between the ADAMTS5 gene polymorphism, rs226794, and knee osteoarthritis. We used a meta-analysis and trial sequential analysis to determine whether ADAMTS5 rs226794 expression increases susceptibility to osteoarthritis. Methods: This study consisted of two parts: a case-control study and a meta-analysis. The case-control study included subjects who underwent knee radiography at the Health Examination Center of the Tri Service General Hospital from 2015 to 2019. The Kellgren–Lawrence (KL) grading system was used as diagnostic criteria. Patients with unsuccessful gene sequencing were excluded. There were 606 subjects in the knee osteoarthritis group (KL ≥ 2) and 564 in the control group (KL < 2). Gene sequencing was performed using iPLEX Gold to determine the association between the gene polymorphism of ADAMTS5 rs226794 and knee osteoarthritis. For the meta-analysis, databases such as PubMed, Embase, and Cochrane were queried to identify studies that examined the relationship between ADAMTS5 rs226794 and osteoarthritis. Next, the findings of the meta-analysis were incorporated with the results of the case-control study and samples from the published studies to estimate the association between the genetic polymorphism and osteoarthritis using an odds ratio and a 95% confidence interval. Results: We found a non-significant association between the G allele and knee OA (crude-OR: 0.93 (95% CI: 0.79–1.10) and adjusted-OR: 1.02 (95% CI: 0.76–1.36) in the allele model) in the present study, and the analysis of other genetic models revealed a similar trend. After including five published studies and our case-control study, the results with 2866 Asians indicated a conclusively null association between ADAMTS5 rs226794 and knee OA) OR: 1.09 (95% CI: 0.93–1.26). The results for Caucasians also revealed a null association (OR: 1.21 (95% CI: 0.81–1.82)). Conclusions: This study indicates that the gene polymorphism, ADAMTS5 rs226794, is not significantly associated with knee osteoarthritis. Additionally, assuming that the cumulative sample size in the allele model is sufficient, we confirmed that the G allele is not a risk factor for osteoarthritis. This study integrated all available evidence to arrive at this conclusion, and it suggests that no additional studies are necessary.

scholarly journals Betel quid not containing tobacco and oral cancer: A report on a case–control study in Papua New Guinea and a meta-analysis of current evidence

2007 ◽  
Vol 120 (6) ◽  
pp. 1318-1323 ◽  
Author(s):  
Steven J. Thomas ◽  
Christopher J. Bain ◽  
Diana Battistutta ◽  
Andrew R. Ness ◽  
Darius Paissat ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Papua New Guinea ◽  
Case Control Study ◽  
Meta Analysis ◽  
New Guinea ◽  
Case Control ◽  
Betel Quid ◽  
Current Evidence ◽  
Control Study

scholarly journals Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population

2019 ◽  
Vol 39 (2) ◽  
Author(s):  
Genjun Chen ◽  
Shengping Hu ◽  
Zhen Lai ◽  
Binsong Qiu
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Joint Destruction ◽  
Case Control ◽  
Joint Disease ◽  
Chinese Han ◽  
Ace Gene ◽  
Knee Oa ◽  
Increased Risk ◽  
Control Study

Abstract Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee OA. However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case–control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population. The present study found that DD genotype or D allele carriers of ACE gene I/D polymorphism increased the risk of knee OA. Stratification analyses of sex, age, and body mass index (BMI) showed significant associations amongst the groups of females, ≥55 years, and abnormal BMI. In addition, the present study made analysis between ACE I/D polymorphism and some clinical features of OA, and found DD genotype of I/D polymorphism was associated with arthralgia. Furthermore, we undertook a meta-analysis together with the present study between this single nucleotide polymorphism (SNP) and knee OA risk. This meta-analysis found that ACE gene I/D polymorphism was associated with increased risk for OA. Stratification analysis of ethnicity in this meta-analysis indicated that I/D polymorphism increased the risk of knee OA amongst the Asians and Caucasians. In conclusion, this case–control study and meta-analysis suggest that ACE gene I/D polymorphism is associated with increased risk for knee OA.

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