scholarly journals Recently Developed Carbohydrate Based Gelators and Their Applications

Gels ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. 24
Author(s):  
Joedian Morris ◽  
Jonathan Bietsch ◽  
Kristen Bashaw ◽  
Guijun Wang
Keyword(s):  
Molecular Weight ◽  
Environmental Remediation ◽  
Rational Design ◽  
Materials Science ◽  
Structural Features ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Ion Sensing ◽  
Self Assembling ◽  
Low Molecular Weight Gelators

Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versatile structures available from naturally existing monosaccharides have enriched the molecular libraries that can be used for the construction of gelators. The bottom-up strategy in designing low molecular weight gelators (LMWGs) for a variety of applications has been adopted by many researchers. Rational design, along with some serendipitous discoveries, has resulted in multiple classes of molecular gelators. This review covers the literature from 2017–2020 on monosaccharide based gelators, including common hexoses, pentoses, along with some disaccharides and their derivatives. The structure-based design and structure to gelation property relationships are reviewed first, followed by stimuli-responsive gelators. The last section focuses on the applications of the sugar based gelators, including their utilization in environmental remediation, ion sensing, catalysis, drug delivery and 3D-printing. We will also review the available LMWGs and their structure correlations to the desired properties for different applications. This review aims at elucidating the design principles and structural features that are pertinent to various applications and hope to provide certain guidelines for researchers that are working at the interface of chemistry, biochemistry, and materials science.

scholarly journals Synthesis and characterization of pH responsive D-glucosamine based molecular gelators

2014 ◽  
Vol 10 ◽  
pp. 3111-3121 ◽  
Author(s):  
Navneet Goyal ◽  
Hari P R Mangunuru ◽  
Bargav Parikh ◽  
Sonu Shrestha ◽  
Guijun Wang
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Negative Influence ◽  
Low Molecular Weight ◽  
Ph Responsive ◽  
Triggered Release ◽  
Self Assembling ◽  
Potential Applications ◽  
Low Molecular Weight Gelators ◽  
Neutral Conditions

Small molecular gelators are a class of compounds with potential applications for soft biomaterials. Low molecular weight hydrogelators are especially useful for exploring biomedical applications. Previously, we found that 4,6-O-benzylidene acetal protected D-glucose and D-glucosamine are well-suited as building blocks for the construction of low molecular weight gelators. To better understand the scope of D-glucosamine derivatives as gelators, we synthesized and screened a novel class of N-acetylglucosamine derivatives with a p-methoxybenzylidene acetal protective group. This modification did not exert a negative influence on the gelation. On the contrary, it actually enhanced the gelation tendency for many derivatives. The introduction of the additional methoxy group on the phenyl ring led to low molecular weight gelators with a higher pH responsiveness. The resulting gels were stable at neutral pH values but degraded in an acidic environment. The release profiles of naproxen from the pH responsive gels were also analyzed under acidic and neutral conditions. Our findings are useful for the design of novel triggered release self-assembling systems and can provide an insight into the influence of the the structure on gelation.

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

scholarly journals Carbocycle-Based Organogelators: Influence of Chirality and Structural Features on Their Supramolecular Arrangements and Properties

Gels ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 54
Author(s):  
Rosa M. Ortuño
Keyword(s):  
Smart Materials ◽  
Self Assembly ◽  
Rational Design ◽  
Structural Features ◽  
Stimuli Responsive ◽  
Polycyclic Compounds ◽  
Relative Configuration ◽  
Responsive Materials ◽  
Self Assembling ◽  
Donor Acceptor

The rational design and engineer of organogel-based smart materials and stimuli-responsive materials with tuned properties requires the control of the non-covalent forces driving the hierarchical self-assembly. Chirality, as well as cis/trans relative configuration, also plays a crucial role promoting the morphology and characteristics of the aggregates. Cycloalkane derivatives can provide chiral chemical platforms allowing the incorporation of functional groups and hydrophobic structural units able for a convenient molecular stacking leading to gels. Restriction of the conformational freedom imposed by the ring strain is also a contributing issue that can be modulated by the inclusion of flexible segments. In addition, donor/acceptor moieties can also be incorporated favoring the interactions with light or with charged species. This review offers a perspective on the abilities and properties of carbocycle-based organogelators starting from simple cycloalkane derivatives, which were the key to establish the basis for an effective self-assembling, to sophisticated polycyclic compounds with manifold properties and applications.

Low molecular weight self-assembling peptide-based materials for cell culture, antimicrobial, anti-inflammatory, wound healing, anticancer, drug delivery, bioimaging and 3D bioprinting applications

Soft Matter ◽  
2020 ◽  
Vol 16 (44) ◽  
pp. 10065-10095
Author(s):  
Apurba K. Das ◽  
Pramod K. Gavel
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Cell Culture ◽  
Wound Healing ◽  
Rational Design ◽  
Low Molecular Weight ◽  
3D Bioprinting ◽  
Anticancer Drug Delivery ◽  
Self Assembling ◽  
Anti Inflammatory

This article emphasizes on the rational design and development of self-assembling peptide-based materials for cell culture, antimicrobial, anti-inflammatory, anticancer, wound healing, drug delivery, bioimaging and 3D bioprinting applications.

scholarly journals Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

2021 ◽  
Author(s):  
Sayuri L. Higashi ◽  
Masato Ikeda
Keyword(s):  
Molecular Weight ◽  
Molecular Design ◽  
Soft Materials ◽  
Amino Sugar ◽  
Low Molecular Weight ◽  
Stimuli Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembling ◽  
Hydrogel Formation

Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

scholarly journals Expanding the scope of gels – combining polymers with low-molecular-weight gelators to yield modified self-assembling smart materials with high-tech applications

2015 ◽  
Vol 2 (3) ◽  
pp. 279-293 ◽  
Author(s):  
Daniel J. Cornwell ◽  
David K. Smith
Keyword(s):  
Molecular Weight ◽  
Hybrid Materials ◽  
Smart Materials ◽  
Simple Approach ◽  
High Tech ◽  
Low Molecular Weight ◽  
Self Assembling ◽  
Low Molecular Weight Gelators

Combining polymer technology with low molecular weight gelators offers a simple approach to create hybrid materials which can open up exciting new perspectives and applications.

scholarly journals Facile construction of a family of supramolecular gels with good levofloxacin hydrochloride loading capacity

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12641-12648
Author(s):  
Renyuan Chen ◽  
Caidie Xu ◽  
Yihao Lei ◽  
Hongxin Liu ◽  
Yabin Zhu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Alkyl Chain ◽  
Low Molecular Weight ◽  
Loading Capacity ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelators ◽  
Chain Lengths

A family of low molecular weight gelators with different alkyl chain lengths was constructed, having excellent gelation ability and antibiotic loading capacity. A low molecular weight hydrogelator was obtained by adjusting the length of alkyl chain.

Encapsulation and release of hydrophobic molecules from particles of gelled triglyceride with aminoacid-based low-molecular weight gelators

2017 ◽  
Vol 514 ◽  
pp. 11-20 ◽  
Author(s):  
Sebastian-Camilo Salazar-Bautista ◽  
Asma Chebil ◽  
Guillaume Pickaert ◽  
Caroline Gaucher ◽  
Brigitte Jamart-Gregoire ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Low Molecular Weight Gelators
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