scholarly journals On the Behaviour of Living Cells under the Influence of Ultrasound

Fluids ◽  
2018 ◽  
Vol 3 (4) ◽  
pp. 82 ◽  
Author(s):  
David Rubin ◽  
Nicole Anderton ◽  
Charl Smalberger ◽  
Jethro Polliack ◽  
Malavika Nathan ◽  
...  
Keyword(s):  
Living Cells ◽  
Review Article ◽  
Medical Ultrasound ◽  
Biological Cells ◽  
Membrane Permeation ◽  
Non Invasive ◽  
Concise Overview ◽  
Ultrasound Technology ◽  
Tissue Structures

Medical ultrasound technology is available, affordable, and non-invasive. It is used to detect, quantify, and heat tissue structures. This review article gives a concise overview of the types of behaviour that biological cells experience under the influence of ultrasound only, i.e., without the presence of microbubbles. The phenomena are discussed from a physics and engineering perspective. They include proliferation, translation, apoptosis, lysis, transient membrane permeation, and oscillation. The ultimate goal of cellular acoustics is the detection, quantification, manipulation and eradication of individual cells.

A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode

Lab on a Chip ◽  
2017 ◽  
Vol 17 (24) ◽  
pp. 4294-4302 ◽  
Author(s):  
Franziska D. Zitzmann ◽  
Heinz-Georg Jahnke ◽  
Felix Nitschke ◽  
Annette G. Beck-Sickinger ◽  
Bernd Abel ◽  
...  
Keyword(s):  
Real Time ◽  
Microfluidic Chip ◽  
Microelectrode Array ◽  
Fem Simulation ◽  
Receptor Activation ◽  
Living Cells ◽  
Real Time Monitoring ◽  
Non Invasive ◽  
Npy Receptor ◽  
Simulation Based

We present a FEM simulation based step-by-step development of a microelectrode array integrated into a microfluidic chip for the non-invasive real-time monitoring of living cells.

Vascular Duplex Study: A Historical Perspective

2021 ◽  
Vol 14 (1) ◽  
pp. 55-60
Author(s):  
Abul Hasan Muhammad Bashar
Keyword(s):  
Present Article ◽  
Medical Practice ◽  
Historical Perspective ◽  
Medical Science ◽  
Diagnosis And Treatment ◽  
Recent History ◽  
Medical Ultrasound ◽  
Historical Aspects ◽  
Ultrasound Technology

Ultrasound is a key investigating tool aiding diagnosis and treatment in the day-to-day medical practice nowadays. Like any other invention, ultrasound technology also has a long history strewn with successes and setbacks. From its modest beginning, it has come a long way to be applied not only in medical science but also in many other areas including navigation and warfare. Scientistsengineers, physicists, mathematicians, biomedical engineers and physicians worked relentlessly over centuries to bring about developments in the field of ultrasound technology as a whole. Medical ultrasound has a relatively recent history that has seen great dedication and commitment from researchers to achieve the degree of finesse we see today. The present article looks back on the historical aspects of ultrasound technology with a focus on medical ultrasound. Cardiovasc j 2021; 14(1): 55-60

Large Deformation of Biological Cells by Optical Tweezers

2003 ◽  
Author(s):  
S. Suresh ◽  
C. T. Lim ◽  
M. Dao
Keyword(s):  
Optical Tweezers ◽  
Mechanical Test ◽  
Living Cells ◽  
Test Methods ◽  
Mechanical Forces ◽  
Deformation Characteristics ◽  
Biological Cells ◽  
Whole Cells ◽  
Aspiration Technique ◽  
Stress States

The chemical and biological functions of living cells are known to be influenced strongly by mechanical forces and deformation, and the ability of cells to detect and support forces, in turn, is also affected by chemical and biological factors. Furthermore, the progression of a number of inherited and infectious diseases have also been identified to have a strong correlation with the mechanical deformation characteristics of biological cells. Consequently, the deformation characteristics of whole cells and cell membranes have long been investigated using a variety of experimental methods, such as the micropipette aspiration technique, and by computational modeling (see, for example, refs. [1, 2]). Recent advances in experimental techniques capable of probing mechanical forces and displacements to a resolution of picoNewton and nanometer, respectively, have facilitated use of mechanical test methods for living cells whereby precise measurements of response under different stress states could be investigated.

Should we still be testing for asymptomatic non-specific urethritis in departments of genitourinary medicine?

2005 ◽  
Vol 16 (4) ◽  
pp. 273-277 ◽  
Author(s):  
P J Horner
Keyword(s):  
Current Practice ◽  
Cost Effective ◽  
Review Article ◽  
Nucleic Acid Amplification ◽  
Sexually Transmitted ◽  
Non Invasive ◽  
Genitourinary Medicine ◽  
The Cost ◽  
Urine Specimens ◽  
Asymptomatic Men

It has recently been advocated that non-invasive testing with first-catch urine specimens using nucleic acid amplification techniques, to detect Chlamydia trachomatis and Neisseria gonorrhoeae, should replace routine microscopy on asymptomatic men. Although it is assumed that this strategy will be cost effective, the available evidence suggests that this will result in fewer sexually transmitted infections being averted than continuing the current practice of screening for urethritis and testing for both microorganisms in asymptomatic men. This review article summarizes the available evidence and argues that research is urgently needed in order to properly evaluate the cost-effectiveness of detecting urethritis in asymptomatic men.

Ultrasound in paediatric cardiology — state of the art

2011 ◽  
Author(s):  
Luc L. Mertens
Keyword(s):  
Heart Disease ◽  
Cardiac Catheterization ◽  
Clinical Skills ◽  
Diagnostic Technique ◽  
Paediatric Cardiology ◽  
Non Invasive ◽  
Doppler Data ◽  
Echocardiographic Examination ◽  
Cardiac Evaluation ◽  
Ultrasound Technology

The development of ultrasound technology to visualize cardiac structures, based on the pioneering work by Edler and Hertz at the University of Lund in Sweden, has literally created a revolution in the field of paediatric cardiology. Before the era of cardiac catheterization and echocardiography the diagnosis of congenital heart disease was mainly based on combining physical findings, cardiac auscultation, electrocardiogram (ECG), and chest X-ray. This was largely based on the work by Helen B. Taussig at John Hopkins in the 1930s who established the field of clinical paediatric cardiology by integrating pathology knowledge with clinical findings. Diagnosis at that time was based on clinical skills and was more an art than science. The introduction of paediatric cardiac surgery in the 1950s was made possible due to the simultaneous development of cardiac catheterization and angiography which allowed an accurate description of the different cardiac lesions and the associated haemodynamics prior to surgery. For a long period catheterization was the diagnostic gold standard and all surgical patients underwent an invasive cardiac evaluation. In the 1970s, echocardiography was developed as a clinical tool and due to its non-invasive nature, was introduced quickly in paediatric cardiology. As anatomical diagnosis is challenging by M-mode echocardiography, it was really the development of two-dimensional (2-D) echocardiography in the late 1970s and early 1980s that deeply influenced the field. For the first time the congenital defects could be imaged noninvasively and the 2-D images were extensively validated by comparing them with pathological and surgical findings. Adding pulsed, continuous, and colour Doppler data to the 2-D images resulted in a complete detailed description of congenital cardiac defects and their haemodynamic consequences. Further optimization of ultrasound technology specifically for paediatric imaging, such as the development of higher-frequency probes and increasing the standard grey-scale frame rates, further improved spatial and temporal resolution and overall image quality. Based on its excellent diagnostic accuracy and its non-invasive nature, echocardiography quickly became the primary non-invasive diagnostic technique for all children with heart disease. Currently every paediatric patient with suspected heart disease will undergo an echocardiographic examination as the first (and often only) diagnostic test.

Non-invasive in-situ quantitative observation of biological cells by acoustic microscopy

2016 ◽  
Vol 140 (4) ◽  
pp. 3245-3245 ◽  
Author(s):  
Naohiro Hozumi ◽  
Kyoichi Takanashi ◽  
Mamoru Washiya ◽  
Sachiko Yoshida ◽  
Kazuto Kobayashi ◽  
...  
Keyword(s):  
Acoustic Microscopy ◽  
Biological Cells ◽  
Non Invasive

Direct non-invasive observation of metabolism in living cells by 13C nuclear magnetic resonance spectroscopy

1980 ◽  
Vol 58 (17) ◽  
pp. 1839-1846 ◽  
Author(s):  
Gerardo Burton ◽  
Robert L. Baxter ◽  
J. Martyn Gunn ◽  
Philip J. Sidebottom ◽  
Paul E. Fagerness ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Anaerobic Metabolism ◽  
Aminolevulinic Acid ◽  
Living Cells ◽  
Resonance Spectroscopy ◽  
Whole Cells ◽  
Non Invasive ◽  
13C Nuclear Magnetic Resonance ◽  
C Nmr

Applications of 13C nmr in following the metabolism and fate of 13C enriched substrates in whole cells are described. Studies on the elaboration of coproporphyrinogens I (2a) and III (2b) from [5-13C]-δ-aminolevulinic acid (1) and [11-13C-porphobilinogen (PBG, 3), in Rhodopseudomonasspheroides and Propionibacteriumshermanii, respectively, the randomization of 13C from [3-13C]-propionate by P. shermanii, the biosynthesis of citrate, gentisalcohol (4), and patulin (5) from [2-13C]-acetate by Penicilliumurticae, and the anaerobic metabolism of [1-13C]-glucose in rabbit erythrocytes are reported.

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