scholarly journals The Core of Medical Imaging: State of the Art and Perspectives on the Detectors

Electronics ◽  
2021 ◽  
Vol 10 (14) ◽  
pp. 1642
Author(s):  
Maria Filomena Santarelli ◽  
Giulio Giovannetti ◽  
Valentina Hartwig ◽  
Simona Celi ◽  
Vincenzo Positano ◽  
...  
Keyword(s):  
Medical Imaging ◽  
Thermal Imaging ◽  
Near Infrared ◽  
New Technologies ◽  
State Of The Art ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Emission Tomography ◽  
Positron Emission

In this review, the roles of detectors in various medical imaging techniques were described. Ultrasound, optical (near-infrared spectroscopy and optical coherence tomography) and thermal imaging, magnetic resonance imaging, computed tomography, single-photon emission tomography, positron emission tomography were the imaging modalities considered. For each methodology, the state of the art of detectors mainly used in the systems was described, emphasizing new technologies applied.

Radioligands for imaging myocardial α- and β-adrenoceptors

2003 ◽  
Vol 42 (01) ◽  
pp. 4-9 ◽  
Author(s):  
M. Schäfers ◽  
M. P. Law ◽  
T. Wichter ◽  
O. Schober ◽  
B. Riemann
Keyword(s):  
Single Photon ◽  
Heart Function ◽  
Specific Binding ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Relative Increase ◽  
Emission Tomography ◽  
Adrenoceptor Antagonist ◽  
Positron Emission ◽  
Cardiac Adrenoceptors

SummaryAlpha- and beta-adrenoceptors play an important role in the control of heart function. According to their molecular, biological, and pharmacological characteristics, they are subdivided into α1-, α2- and β1-, β2-, β3-, β4-adrenoceptors. In cardiac disease, there is often a selective downregulation of β1-adrenoceptors associated with a relative increase in β2- and α1-adrenoceptors. Functional imaging techniques like single-photon emission tomography (SPECT) and positron emission tomography (PET) provide the unique capability for non-invasive assessment of cardiac adrenoceptors. Radioligands with high specific binding to cardiac α- and β-adrenoceptors suitable for radiolabelling are required for clinical studies. The non-selective β-adrenoceptor antagonist [11C]CGP-12177 was used to quantify β-adrenoceptor density using PET in patients with heart disease. New non-selective ligands (e. g. [11C]CGP-12388, [18F]CGP-12388, [11C]carazolol and [18F]fluorocarazolol) are currently evaluated; β1-selective radioligands (e. g. [11C]CGP-26505, [11C]bisoprolol, [11C]HX-CH 44) and β2-selective radioligands (e. g. [11C]formoterol, [11C]ICI-118551) were assessed in animals. None of them turned out as suitable for cardiac PET.Potential radioligands for imaging cardiac α1-adrenoceptors are based on prazosin. Whereas [11C]prazosin shows low specific binding to myocardium, its derivative [11C]GB67 looks more promising. The putative α2-adrenoceptor radioligand [11C]MK-912 shows high uptake in rodent myocardium but has not yet been evaluated in man.A number of radioligands were evaluated for assessing cardiac adrenoceptors using PET. New radioligands are needed to provide more insight into cardiac pathophysiology which may influence the therapeutic management of patients with cardiovascular disease.

Functional Neuroimaging in Neurology and Psychiatry

CNS Spectrums ◽  
2002 ◽  
Vol 7 (4) ◽  
pp. 286-299 ◽  
Author(s):  
Joseph R. Sadek ◽  
Thomas A. Hammeke
Keyword(s):  
Functional Neuroimaging ◽  
Single Photon ◽  
Imaging Techniques ◽  
Cognitive Task ◽  
Photon Emission ◽  
Emission Tomography ◽  
Clinical Neurology ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Positron Emission

ABSTRACTHow can functional neuroimaging be applied to clinical neurology and psychiatry? This article reviews selected contributions of functional neuroimaging to the clinical neurosciences. We review selected technical aspects of positron emission tomography, single photon emission tomography, and functional magnetic resonance imaging with a focus on the relative strengths and weaknesses of these techniques. Consumers of functional neuroimaging research are encouraged to consider the limitations of imaging techniques and theoretical pitfalls of cognitive task design when interpreting results of functional imaging studies. Then, we selectively review the contributions of functional neuroimaging to neurology and psychiatry, including the areas of epilepsy, stroke, chronic pain, schizophrenia, depression, and obsessive-compulsive disorder. Future directions of functional neuroimaging research are offered, with the emphasis that the best conclusions are informed by a convergence of research from functional neuroimaging, neurophysiological, and lesion studies.

scholarly journals A literature review on multimodality molecular imaging nanoprobes for cancer detection

2019 ◽  
Vol 25 (2) ◽  
pp. 57-68 ◽  
Author(s):  
Daryoush Shahbazi-Gahrouei ◽  
Pegah Moradi Khaniabadi ◽  
Saghar Shahbazi-Gahrouei ◽  
Amir Khorasani ◽  
Farshid Mahmoudi
Keyword(s):  
Molecular Imaging ◽  
Cancer Detection ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Emission Tomography ◽  
Imaging Modalities ◽  
Single Photon Emission ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri

Abstract Molecular imaging techniques using nanoparticles have significant potential to be widely used for the detection of various types of cancers. Nowadays, there has been an increased focus on developing novel nanoprobes as molecular imaging contrast enhancement agents in nanobiomedicine. The purpose of this review article is to summarize the use of a variety of nanoprobes and their current achievements in accurate cancer imaging and effective treatment. Nanoprobes are rapidly becoming potential tools for cancer diagnosis by using novel molecular imaging modalities such as Ultrasound (US) imaging, Computerized Tomography (CT), Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and Optical Imaging. These imaging modalities may facilitate earlier and more accurate diagnosis and staging the most of cancers.

A Review of the Postconcussion Syndrome

1992 ◽  
Vol 22 (4) ◽  
pp. 357-375 ◽  
Author(s):  
Herman V. Szymanski ◽  
Richard Linn
Keyword(s):  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Emission Tomography ◽  
Postconcussion Syndrome ◽  
Topic Area ◽  
Her Family ◽  
Memory Problems ◽  
Positron Emission ◽  
Neuropsychological Changes

Objective: This review will focus on aspects of the postconcussion syndrome (PCS), including accompanying symptomatology, neuropsychological changes, brain imaging studies and treatment. Method: In each topic area, those research studies resulting in the most interpretable data are reported. Since there is little research in some aspects of the PCS, some studies of limited merit are described, with their limitations outlined, in lieu of not reporting any study. The section on psychopharmacology largely consists of opinions of recognized clinicians, since there is almost no research on the psychopharmacology of PCS. Results: Mild traumatic brain injury is a relatively frequent occurrence which often results in the postconcussion syndrome (PCS), consisting of complaints of irritability, fatigue, headache, difficulty concentrating, dizziness, and memory problems. Anxiety and depression are also frequently present, especially later in its course. Although the PCS has often been thought to reflect a psychological response to injury, there is considerable recent evidence to suggest that it is primarily a physiologic disturbance. For most individuals, treatment consists primarily of education of the patient and his/her family, along with supportive counseling regarding emerging problems at work or at home. A subgroup of patients, however, may require psychopharmacologic intervention. Conclusion: More research is needed in all aspects of PCS, especially its neurophysiology and pharmacologic treatment. Relationships between neurophysiological changes and behavioral and neuropsychological changes are unknown. New imaging techniques, such as single-photon emission tomography, and positron emission tomography will likely play an important role in understanding the physiology of this disorder.

scholarly journals Cardiac Autonomic Nervous System and Ventricular Arrhythmias: The Role of Radionuclide Molecular Imaging

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1273
Author(s):  
Andreas Fesas ◽  
Evanthia Giannoula ◽  
Alexis Vrachimis ◽  
Argyrios Doumas ◽  
Christian Wenning ◽  
...  
Keyword(s):  
Nervous System ◽  
Molecular Imaging ◽  
Ventricular Arrhythmias ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Emission Tomography ◽  
Autonomous Nervous System ◽  
Cardiac Autonomic Nervous System ◽  
Positron Emission

Widely established compared to myocardial perfusion imaging, cardiac autonomous nervous system (CANS) assessment by radiopharmaceutical means is of potential use especially to arrhythmogenic diseases not correlated with anatomic or functional alterations revealed by classical imaging techniques. Molecular imaging of both pre- and postsynaptic functions of the autonomous nervous system is currently feasible, since single photon emission tomography (SPECT) and positron emission tomography (PET) have the ability to reveal the insights of molecular pathophysiology depicting both sympathetic and parasympathetic imbalance in discrete heart pathologies. This review provides not only a brief presentation of radiopharmaceuticals used for non-invasive CANS imaging in the case of ventricular arrhythmias, but also a current update on ventricular tachycardias, cardiomyopathies, Brugada and Long QT syndrome literature.

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