scholarly journals Effect of Collagen Cross-Link Deficiency on Incorporation of Grafted Bone

2019 ◽  
Vol 7 (2) ◽  
pp. 45
Author(s):  
Suliman Mubarak ◽  
Nagasawa Masako ◽  
Farah A. Al-Omari ◽  
Hamaya Keisuke ◽  
Uoshima Katsumi
Keyword(s):  
Bone Quality ◽  
Bone Matrix ◽  
Bone Transplantation ◽  
Host Bone ◽  
Recipient Site ◽  
Key Factor ◽  
Cross Links ◽  
Bone Quantity ◽  
Zero Test ◽  
Bone Effect

Bone matrix collagen, is one of the major contributors to bone quality. No studies have examined how bone quality affects the results of bone transplantation. Collagen cross-links (CCL) are the key factor in collagen properties. The purpose was to investigate the influences of CCL for both grafted bone and recipient site bone on the success of bone augmentation. Four-week-old male Wister rats (n = 54) were divided into control and test groups. Control and test groups equally sub-divided into donors and recipients. An additional six rats were used to characterize bone at day zero. Test groups received 0.2% beta-aminoproperionitrile (BAPN) for 4 weeks as CCL inhibitor. Animals were further divided into donor and recipient groups. The transplanted bone chips integrated with host bone by 25% more in CCL-deficient animals compared to control. However, no difference in cortical thickness among all conditions. CCL-deficient transplanted bone did not show any extra signs of osteocyte apoptosis, while sclerostin expression was comparable to that in control. The host periosteum of CCL-deficient animals showed higher cellular activity, as well as higher bone quantity and osteoclast activity. Collagen cross-links deficiency in host bone might accelerate the incorporation of grafted bone. effect. Incorporation of the bone grafts appears to depend mainly on host condition rather than graft condition.

Variations in trabecular bone composition with anatomical site and age: potential implications for bone quality assessment

1997 ◽  
Vol 155 (3) ◽  
pp. 411-421 ◽  
Author(s):  
J Aerssens ◽  
S Boonen ◽  
J Joly ◽  
J Dequeker
Keyword(s):  
Lumbar Spine ◽  
Trabecular Bone ◽  
Bone Quality ◽  
Bone Matrix ◽  
Anatomical Site ◽  
Bone Composition ◽  
Age Related ◽  
Skeletal Site ◽  
Igf I ◽  
Age Range

Skeletal site-related differences in trabecular bone composition have been studied in autopsy samples from 63 individuals (age range 23-92 years). From each individual, bone samples were excised from the iliac crest, lumbar spine, femoral neck, and calcaneus. Samples were analyzed for their content of ash, calcium, collagen, extractable proteins, osteocalcin, and IGF-I. Significant differences were found between the skeletal sites, the lumbar spine being the least mineralized site and the femur the most. The femur and lumbar spine had a higher osteocalcin and IGF-I content compared with the other skeletal sites, suggesting a higher bone turnover rate. The intercorrelations between the anatomical sites were low for minerals and collagen but high for osteocalcin and IGF-I. The latter might indicate that the presence of these proteins in the bone matrix is mainly controlled by endocrine mechanisms which may influence the osteoblast function. Finally, regression analysis showed a significant age-related decrease of skeletal IGF-I at all sites examined. This finding supports the hypothesis of an IGF-I-mediated pathogenesis of senile osteoporosis. In summary, our data imply that a global assessment of skeletal function and bone quality, based upon analyses at one anatomical site, should be applied with caution.

scholarly journals Bone quality: what is it and how is it measured?

2006 ◽  
Vol 50 (4) ◽  
pp. 579-585 ◽  
Author(s):  
Juliet Compston
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Fracture Risk ◽  
Bone Strength ◽  
Bone Quality ◽  
Bone Mineral ◽  
Bone Matrix ◽  
Mineral Density ◽  
New Techniques ◽  
Composition And Structure

Bone quality describes aspects of bone composition and structure that contribute to bone strength independently of bone mineral density. These include bone turnover, microarchitecture, mineralisation, microdamage and the composition of bone matrix and mineral. New techniques to assess these components of bone quality are being developed and should produce important insights into determinants of fracture risk in untreated and treated disease.

Basic considerations for determining the amount of press fit in acetabular cup endoprostheses as a function of the elastic bone behavior

2014 ◽  
Vol 0 (0) ◽  
Author(s):  
Werner Winter ◽  
Matthias Karl
Keyword(s):  
Elastic Properties ◽  
Element Model ◽  
Host Bone ◽  
Pelvic Bone ◽  
Specific Situation ◽  
Acetabular Cup ◽  
Mineral Density ◽  
Recipient Site ◽  
Press Fit ◽  
Implant Selection

AbstractAcetabular cup endoprostheses are frequently placed in pelvic bone, employing the mechanical principle of press fit. While a sufficiently stable bone-implant connection is desirable, deformation of the cup and fracture of the pelvis should be avoided. The goal of this work is to demonstrate the importance of the elastic properties of bone on the amount of press fit achievable in a specific situation. On the basis of previous work describing the relation between relative bone mineral density and relative elastic modulus for cortical and trabecular bone, mechanical equations were used for analyzing the press-fit loading situation of an acetabular cup. Additionally, a two-dimensional finite element model was used for visualizing the stress and strain situation in the host bone occurring as a consequence of implant insertion, as well as the effect of moment loads acting on the acetabular cup. Given the fact that oversizing the implant for a specific recipient site is the only clinical means of optimizing press fit, knowledge of the elastic properties of the host bone before implant selection would be beneficial. Such information could, for instance, be derived from intraoperative compressive testing of the host bone.

Use of Porous Bone Mineral to Increase Bone Density

1993 ◽  
Vol 331 ◽  
Author(s):  
Philip J. Boyne
Keyword(s):  
Bone Density ◽  
Bone Mineral ◽  
Bone Matrix ◽  
Term Effect ◽  
Recipient Site ◽  
Metal Implant ◽  
Long Term Effect

Abstract:The amount of bone density in a metal implant recipient site markedly effects the success of the implant and the prosthesis. Therefore mechanisms designed to enhance bone density are necessary. Porous bone mineral (BioOss) was used in this study to demonstrate the ability of this product to be slowly resorbed and remodelled, and to enhance in the remodelling process of the amount of calcified bone matrix available for reception of any subsequent placed prosthesis. Further research on the effect of functional prosthesis on the osseous matrix and the long term effect of function on the increase bone matrix is needed.

PHYSICAL ACTIVITY, BONE QUALITY AND BONE QUANTITY IN PRE- AND PERI-MENOPAUSAL WOMEN 13

1996 ◽  
Vol 28 (Supplement) ◽  
pp. 3
Author(s):  
E W Gregg ◽  
A M Kriska ◽  
L A Salamone ◽  
L Simkin-Silverman ◽  
S J Anderson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Quality ◽  
Menopausal Women ◽  
Bone Quantity

Bone Regeneration Based on Orientation of Biological Apatite (BAp) C-Axis in Osteopetrotic (op/op) Mice

2010 ◽  
Vol 638-642 ◽  
pp. 588-593 ◽  
Author(s):  
Jee Wook Lee ◽  
Keita Kawahara ◽  
Takayoshi Nakano
Keyword(s):  
Bone Regeneration ◽  
Bone Quality ◽  
Bone Cells ◽  
Hexagonal Lattice ◽  
Recovery Process ◽  
Quality Parameters ◽  
Mineral Density ◽  
Dominant Component ◽  
Biological Apatite ◽  
Bone Quantity

The diagnosis of hard tissues is generally carried out by bone mineral density (BMD) measurement as a bone quantity parameter. BMD, however, does not necessarily explain bone fracture risks in some clinical cases. Recently, various parameters relating to bone strength have been investigated. These additional parameters, so-called bone quality, reflect intrinsic bone conditions. We have been studying the preferential alignment of the biological apatite (BAp) c-axis among various bone quality parameters. BAp, a dominant component of hard tissue, is an ionic crystal that crystallizes in a hexagonal lattice accompanied with the anisotropic property. In this article, we investigated the osteoclast role in the recovery process of BAp orientation during bone regeneration using osteopetrotic (op/op) mice in which the number of osteoclasts decreases. A surgically drilled, 500-μm diameter hole on each tibia of both control and op/op 8-week-old mice was introduced from the medial surface into the medullary cavity located at a 30% length from the proximal tibia end. After surgery, tibiae injuries were regularly observed by in situ micro-CT, and then the mice were sacrificed four to eight weeks after surgery. BAp orientation was analyzed in and near the regenerated portion by the microbeam X-ray diffraction system. As a result, we found the insufficient recovery of BAp orientation in spite of the apparent repair of bone appearance and quantity from CT images, even eight weeks after surgery in both cases of control and op/op mice. We conclude that this defective animal model can be used to evaluate bone quantity and quality at the cortical portion during bone regeneration in gene-defect mice in which the expression of bone cells is controlled, for example.

scholarly journals Silicon supplementation affects mineral metabolism but not bone density or strength in male broilers

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243007
Author(s):  
Abby Pritchard ◽  
Cara Robison ◽  
Tristin Nguyen ◽  
Brian D. Nielsen
Keyword(s):  
Bone Density ◽  
Bone Quality ◽  
Mineral Metabolism ◽  
Positive Influence ◽  
Water Control ◽  
Leg Injuries ◽  
Treatment Groups ◽  
Four Point Bending ◽  
Cross Links ◽  
Daily Water

Because leg injuries produce welfare concerns and impact production for broilers, numerous interventions have been suggested as potential solutions. One mineral which may affect bone quality is silicon. The objective of this study was to determine if supplementing bioavailable silicon could affect bone morphology, mineralization, and strength without negatively influencing welfare and meat quality. Male broilers were raised from d 1 after hatching until 42 d of age and randomly assigned to treatment groups for silicon supplementation in water: Control (no supplement, C; n = 125), Normal (0.011 ml supplement/kg bodyweight, N; n = 125) and High (0.063 ml supplement/kg bodyweight, H; n = 125). Toe damage, footpad dermatitis, hock burn, and keel blisters were assessed on d 42. Blood samples were collected from wing veins for serum osteocalcin, pyridinoline cross-links, and mineral analysis. Clinical QCT scans and analysis were conducted immediately before four-point bending tests of tibias. Texture analysis was performed on cooked fillets. Silicon supplementation tended to increase daily water consumption in N and H as compared to C (P = 0.07). Footpad dermatitis and hock burn scores were higher in H than in N or C (P < 0.05 for both comparisons). Supplementation altered serum minerals (P < 0.001), but bone density, morphology, and strength measures were similar among groups. The highest level of supplementation in the current study on a kg bodyweight basis was above recommended intakes but below previous amounts demonstrating silicon’s positive influence on bone, indicating that previously suggested minimum thresholds need to be reevaluated. Factors such as growth rate and mechanical loading likely play a greater role in developing bone quality than trying to supplement on top of good basic nutrition alone.

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