scholarly journals Volumetric Imaging of Lung Tissue at Micrometer Resolution: Clinical Applications of Micro-CT for the Diagnosis of Pulmonary Diseases

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2075
Author(s):  
Andreana Bompoti ◽  
Andreas S. Papazoglou ◽  
Dimitrios V. Moysidis ◽  
Nikolaos Otountzidis ◽  
Efstratios Karagiannidis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Lung Diseases ◽  
Human Lung ◽  
Imaging Modality ◽  
Clinical Applications ◽  
Ct Imaging ◽  
Micro Ct ◽  
Volumetric Imaging ◽  
Scoping Reviews

Micro-computed tomography (micro-CT) is a promising novel medical imaging modality that allows for non-destructive volumetric imaging of surgical tissue specimens at high spatial resolution. The aim of this study is to provide a comprehensive assessment of the clinical applications of micro-CT for the tissue-based diagnosis of lung diseases. This scoping review was conducted in accordance with the PRISMA Extension for Scoping Reviews, aiming to include every clinical study reporting on micro-CT imaging of human lung tissues. A literature search yielded 570 candidate articles, out of which 37 were finally included in the review. Of the selected studies, 9 studies explored via micro-CT imaging the morphology and anatomy of normal human lung tissue; 21 studies investigated microanatomic pulmonary alterations due to obstructive or restrictive lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and cystic fibrosis; and 7 studies examined the utility of micro-CT imaging in assessing lung cancer lesions (n = 4) or in transplantation-related pulmonary alterations (n = 3). The selected studies reported that micro-CT could successfully detect several lung diseases providing three-dimensional images of greater detail and resolution than routine optical slide microscopy, and could additionally provide valuable volumetric insight in both restrictive and obstructive lung diseases. In conclusion, micro-CT-based volumetric measurements and qualitative evaluations of pulmonary tissue structures can be utilized for the clinical management of a variety of lung diseases. With micro-CT devices becoming more accessible, the technology has the potential to establish itself as a core diagnostic imaging modality in pathology and to enable integrated histopathologic and radiologic assessment of lung cancer and other lung diseases.

scholarly journals Quantitative 3D Micro-CT Imaging of Human Lung Tissue

2013 ◽  
Vol 185 (09) ◽  
pp. 869-876 ◽  
Author(s):  
M. Kampschulte ◽  
C. Schneider ◽  
H. Litzlbauer ◽  
D. Tscholl ◽  
C. Schneider ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Human Lung ◽  
Ct Imaging ◽  
Micro Ct ◽  
Human Lung Tissue

scholarly journals Quantitative 3D Micro-CT Imaging of Human Lung Tissue

2013 ◽  
Vol 185 (09) ◽  
pp. 869-876 ◽  
Author(s):  
M. Kampschulte ◽  
C. Schneider ◽  
H. Litzlbauer ◽  
D. Tscholl ◽  
C. Schneider ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Human Lung ◽  
Ct Imaging ◽  
Micro Ct ◽  
Human Lung Tissue

scholarly journals ANTIOXIDANT-VITAMIN C: LUNG FUNCTION; LUNG CANCER

2016 ◽  
pp. 43
Author(s):  
Mazahar Farooqui ◽  
Rajendra Pardeshi ◽  
Santosh Jadhav
Keyword(s):  
Lung Cancer ◽  
Lung Function ◽  
Vitamin C ◽  
Lung Tissue ◽  
Lung Diseases ◽  
Daily Life ◽  
Antioxidant Vitamin ◽  
Vegetables And Fruits ◽  
The Relationship ◽  
Lung Tissue Damage

<p>ABSTRACT<br />Non-enzymatic vitamin C (ascorbic acid) plays an important role in the medicinal field and acts as antioxidants use in fruits and vegetable such as<br />lemon, orange, grapes, carrots, tomatoes, grapefruit, beans, broccoli, and mangos. It helps to prevent and stop of various diseases such as lung cancer,<br />asthma, and wheezing and finding an antibronchospastic effect. Other factors such as diet have also been implicated in the development of lung<br />cancer. Despite the extensive research conducted in this area, the relationship between diet and lung cancer is still not clear. Diets high in fat and<br />low in vegetables and fruits may increase the risk of lung cancer and other fact eating of tobacco and smoking of cigarette. Lung tissue damage due<br />to high levels of free radicals in cigarette smoke causes direct (tissue oxidation) and indirect (release of oxidizing agents and enzymes). Vitamin C is<br />necessary for phagocytosis. It plays a significant role in daily life, dietary system like eating food, vegetable and smoking of cigarette. It helps to prevent<br />or stop the damage the lung tissue/or cause lung cancer. The present review studied that application of vitamin C act as antioxidant in lung cancer like<br />diseases such as lung-cancer and role in lung function.<br />Keywords: Review, Non-enzymatic antioxidant (vitamin C), Lung function, Lung diseases.</p>

scholarly journals Radiolabeling, Characteristics and NanoSPECT/CT Imaging of 188Re-cetuximab in NCI-H292 Human Lung Cancer Xenografts

2018 ◽  
Vol 39 (1) ◽  
pp. 183-190 ◽  
Author(s):  
WAN-I KUO ◽  
KAI-HUNG CHENG ◽  
YA-JEN CHANG ◽  
TSUNG-TSE WU ◽  
WEI-CHUAN HSU ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
Ct Imaging ◽  
Human Lung Cancer

scholarly journals Ethnic Disparities in Imaging Utilization at Diagnosis of Non-Small Cell Lung Cancer

2020 ◽  
Vol 112 (12) ◽  
pp. 1204-1212 ◽  
Author(s):  
Rustain L Morgan ◽  
Sana D Karam ◽  
Cathy J Bradley
Keyword(s):  
Lung Cancer ◽  
Imaging Modality ◽  
Statistical Tests ◽  
Ethnic Disparities ◽  
Cox Proportional Hazards ◽  
Ct Imaging ◽  
Secondary Outcome ◽  
Fee For Service ◽  
Cancer Specific Survival ◽  
Initial Imaging

Abstract Background Prior research demonstrated statistically significant racial disparities related to lung cancer treatment and outcomes. We examined differences in initial imaging and survival between blacks, Hispanics, and non-Hispanic whites. Methods The linked Surveillance, Epidemiology, and End Results-Medicare database between 2007 and 2015 was used to compare initial imaging modality for patients with lung cancer. Participants included 28 881 non-Hispanic whites, 3123 black, and 1907 Hispanics, patients age 66 years and older who were enrolled in Medicare fee-for-service and diagnosed with lung cancer. The primary outcome was comparison of positron emission tomography (PET) imaging with computerized tomography (CT) imaging use between groups. A secondary outcome was 12-month cancer-specific survival. Information on stage, treatment, and treatment facility was included in the analysis. Chi-square test and logistic regression were used to evaluate factors associated with imaging use. Kaplan-Meier method and Cox proportional hazards regression were used to calculate adjusted hazard ratios and survival. All statistical tests were two-sided. Results After adjusting for demographic, community, and facility characteristics, blacks were less likely to undergo PET or CT imaging at diagnosis compared with non-Hispanic whites odds ratio (OR) = 0.54 (95% confidence interval [CI] = 0.50 to 0.59; P &lt; .001). Hispanics were also less likely to receive PET with CT imaging (OR = 0.72, 95% CI = 0.65 to 0.81; P &lt; .001). PET with CT was associated with improved survival (HR = 0.61, 95% CI = 0.57 to 0.65; P &lt; .001). Conclusions Blacks and Hispanics are less likely to undergo guideline-recommended PET with CT imaging at diagnosis of lung cancer, which may partially explain differences in survival. Awareness of this issue will allow for future interventions aimed at reducing this disparity.

Localization and activity of iNOS in normal human lung tissue and lung cancer tissue

2007 ◽  
Vol 22 (3) ◽  
pp. 226-231 ◽  
Author(s):  
L. Speranza ◽  
M.A. De Lutiis ◽  
Y.B. Shaik ◽  
M. Felaco ◽  
A. Patruno ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Cancer Tissue ◽  
Lung Cancer Tissue ◽  
Human Lung Tissue ◽  
Normal Human

High-Resolution CT Findings of Leukemia Pulmonary Infiltration and Chemotherapy Outcome and In Vitro Study of Human Lung Tissue

2021 ◽  
Vol 11 (2) ◽  
pp. 360-369
Author(s):  
Caide Xie ◽  
Tianjing Zhao ◽  
Liang Fang
Keyword(s):  
High Resolution ◽  
Lung Tissue ◽  
Human Lung ◽  
Ct Imaging ◽  
Imaging Features ◽  
Human Lung Tissue ◽  
High Resolution Ct ◽  
Ct Findings ◽  
Pulmonary Infiltration

In order to explore the high-resolution CT findings of leukemia pulmonary infiltration and chemotherapy outcomes and the in vitro study of human lung tissue, this paper selected a total of 120 clinically or surgically confirmed leukemia patients at the designated hospital of the study from December 2014 to December 2018, and divided them into three groups according to the random number table method: pulmonary infiltration group, chemotherapy outcome group and in vitro study group, with 40 cases in each group. The CT imaging features of the three groups of patients were observed and summarized respectively; the anomalous evaluation indexes of pulmonary parenchyma tissue abnormalities included CT halo sign, air crescent sign, lung segment consolidation, bronchial vascular bundle and nodules; the CT abnormalities such as thickening of the interlobular septum, bronchial interstitial thickening, nodular shadow, ground glassy change, and air cavity consolidation were selected as observation indicators. The results show that all cases have multiple solid nodules or multiple plaques, varying in number, size and distribution, in which 13 cases have multiple patchy shadows, 9 cases have multiple knots and 11 cases have multiple plaques and nodules; lesions are mainly distributed along the bronchial vessels in 21 cases, and 9 cases are along the center of the small leaves and 5 cases are randomly distributed; there are 13 cases that have frosted glass, in which 4 cases with pleural effusion, 9 cases with mold infection, show multiple patchy shadows with halo signs and layered mold balls. In summary, leukemia pulmonary infiltration has polymorphic high-resolution CT findings and chemotherapy outcomes; high-resolution CT imaging and in vitro studies of human lung tissue have important clinical and pathological research value for leukemia infiltration and chemotherapy outcome. The results of this study provide a reference for the further researches on high-resolution CT findings of pulmonary infiltration and chemotherapy outcomes and in vitro studies of human lung tissue.

scholarly journals Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imaging

2010 ◽  
Vol 37 (9) ◽  
pp. 4793-4805 ◽  
Author(s):  
Eman Namati ◽  
Jacqueline Thiesse ◽  
Jessica C. Sieren ◽  
Alan Ross ◽  
Eric A. Hoffman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Progression ◽  
Ct Imaging ◽  
Micro Ct ◽  
Longitudinal Assessment

Elemental analyses in human lung tissue correlated with smoking, emphysema and lung cancer

1989 ◽  
Vol 19 (1-2) ◽  
pp. 1-6 ◽  
Author(s):  
P‐L. Kalliomäki ◽  
P. Kokkonen ◽  
P. Pääkkö ◽  
S. Anttila ◽  
K. Kalliomäki
Keyword(s):  
Lung Cancer ◽  
Lung Tissue ◽  
Human Lung ◽  
Human Lung Tissue ◽  
Elemental Analyses
Sign in / Sign up

Export Citation Format

Share Document