scholarly journals Abdominal Ultrasound and Treatment of Hepatocellular Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1268
Author(s):  
Kazushi Numata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Abdominal Ultrasound ◽  
Cancer Death ◽  
Common Cause ◽  
Cancer Statistics ◽  
The Third ◽  
Common Cancer

Liver cancer is the sixth most common cancer and the third most common cause of cancer death, based on Global Cancer Statistics 2020 [...]

Advances in delivery vectors for gene therapy in liver cancer

2020 ◽  
Vol 11 (1) ◽  
pp. 833-850 ◽  
Author(s):  
Katherine E Redd Bowman ◽  
Phong Lu ◽  
Erica R Vander Mause ◽  
Carol S Lim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Viral Vectors ◽  
Gene Editing ◽  
Cancer Death ◽  
Common Cause ◽  
The Third ◽  
Gene Delivery Vectors ◽  
Efficient Delivery ◽  
Therapy Delivery

Hepatocellular carcinoma (HCC) is the third most common cause of cancer death globally, mainly due to lack of effective treatments – a problem that gene therapy is poised to solve. Successful gene therapy requires safe and efficient delivery vectors, and recent advances in both viral and nonviral vectors have made an important impact on HCC gene therapy delivery. This review explores how adenoviral, retroviral and adeno-associated viral vectors have been modified to increase safety and delivery capacity, highlighting studies and clinical trials using these vectors for HCC gene therapy. Nanoparticles, liposomes, exosomes and virosomes are also featured in their roles as HCC gene delivery vectors. Finally, new discoveries in gene editing technology and their impacts on HCC gene therapy are discussed.

Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2–p53 interaction

2018 ◽  
Vol 9 (10) ◽  
pp. 5336-5349 ◽  
Author(s):  
Nisha Susan Thomas ◽  
Kiran George ◽  
Athavan Alias Anand Selvam
Keyword(s):  
Hepatocellular Carcinoma ◽  
Common Cause ◽  
The Third ◽  
Common Cancer ◽  
Hepatic Tumorigenesis

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third most common cause of mortality worldwide.

scholarly journals Cáncer hepático, problema de salud subestimado

Tequio ◽  
2018 ◽  
Vol 1 (2) ◽  
pp. 69-77
Author(s):  
Adriana Ramírez-Cosmes ◽  
Gabriela Carrasco Torres ◽  
José Fernando Sánchez Pino ◽  
Irving Martínez Contreras ◽  
Rafael Baltierrez Hoyos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Rate ◽  
High Risk ◽  
Liver Cancer ◽  
Diagnostic Methods ◽  
Cancer Death ◽  
The Third ◽  
Common Cancer ◽  
Incidence And Mortality ◽  
Inadequate Nutrition

Liver cancer is the second most common cancer death cause worldwide, the fourth with the highest incidence, and the third most lethal in Mexico. Due to the bad habits and inadequate nutrition of the Mexican population, it is at a high risk of developing this type of disease. At present, it is difficult to make a practical and safe diagnosis of liver cancer in later stages, and it is even more difficult in early stages. This situation, added to the scarce viability and effectiveness of the treatments, and the lack of reliable national incidence records, anticipate a very low survival rate. That is why it requires a greater attention and understanding of this condition, for the identification of therapeutic targets and new timely treatments. In this article we review the main risk factors for liver cancer, their biological characteristics, current diagnostic methods and new proposals for their detection, allowing us to know the contemporary panorama and contribute to research on this health problem and reduce the high rates of incidence and mortality.

scholarly journals Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Naz Fatima ◽  
Tasleem Akhtar ◽  
Nadeem Sheikh
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Antitumor Effect ◽  
Gut Permeability ◽  
Gut Flora ◽  
Effective Barrier ◽  
The Third ◽  
Oncogenic Pathways ◽  
Novel Approach ◽  
Genetic Modifications

Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect.

scholarly journals A Complicated Colorectal Cancer Recurrence

2020 ◽  
Vol 18 (1) ◽  
pp. 25-27
Author(s):  
Anna Marija Lescinska ◽  
Valerija Grakova ◽  
Aleksandrs Malasonoks ◽  
Armands Sivins
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Cancer Recurrence ◽  
Cancer Death ◽  
Treatment Results ◽  
Western Countries ◽  
The Third ◽  
Common Cancer ◽  
One Step ◽  
Colorectal Cancer Recurrence

SummaryThe case report demonstrates painstaking, one step at a time multitherapy for the third most common cancer and the third cause of cancer death in western countries – colorectal cancer. Multitherapeutic approach at specialized centers for the treatment of colorectal cancer is the cornerstone for reaching favorable treatment results and prognosis.

scholarly journals Extracellular Vesicles, A Possible Theranostic Platform Strategy for Hepatocellular Carcinoma—An Overview

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 261 ◽  
Author(s):  
Igea D’Agnano ◽  
Anna Concetta Berardi
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Drug Delivery ◽  
Kinase Inhibitors ◽  
Standard Treatment ◽  
Extracellular Vesicle ◽  
Great Promise ◽  
The Third ◽  
Common Cancer ◽  
Targeted Drug ◽  
Delays In Diagnosis

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third highest cause of mortality from cancer, largely because of delays in diagnosis. There is currently no effective therapy for advanced stage HCC, although sorafenib, the standard treatment for HCC, systemic therapy (including tyrosine kinase inhibitors and anti-angiogenesis agents), and more recently, immunotherapy, have demonstrated some survival benefit. The measurement and modification of extracellular vesicle (EVs) cargoes—composed of nucleic acids, including miRNAs, proteins, and lipids—holds great promise for future HCC diagnosis, prognosis, and treatment. This review will provide an overview of the most recent findings regarding EVs in HCC, and the possible future use of EVs as “liquid biopsy”-based biomarkers for early diagnosis and as a vehicle for targeted drug-delivery.

scholarly journals The Heterogeneity of Liver Cancer Metabolism

2021 ◽  
pp. 127-136
Author(s):  
Javier Salazar ◽  
Anne Le
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Metabolism ◽  
Primary Liver Cancer ◽  
Cancer Death ◽  
The World ◽  
Advanced Stages ◽  
New Biomarkers ◽  
Cancer Tissues

AbstractPrimary liver cancer is the fourth leading cause of cancer death around the world. Histologically, it can be divided into two major groups, hepatocellular carcinoma (75% of all liver cancer) and intrahepatic cholangiocarcinoma (15% of all liver cancer) [1, 2]. Primary liver cancer usually happens in liver disease or cirrhosis patients [1], and the risk factors for developing HCC depend on the etiology [3] and the country of provenance [1]. There is an urgent need for an accurate diagnostic test given the high proportion of false positives and false negatives for alpha-fetoprotein (AFP), a common HCC biomarker [4]. Due to often being diagnosed in advanced stages, HCCrelated deaths per year have doubled since 1999 [3]. With the use of metabolomics technologies [5], the aberrant metabolism characteristics of cancer tissues can be discovered and exploited for the new biomarkers and new therapies to treat HCC [6, 7].

Evaluate Survival Rate of Hepatocellular Carcinoma in Yazd from 1390 to 1394

2021 ◽  
Vol 15 (8) ◽  
pp. 2339-2345
Author(s):  
Shokoh Taghipour ◽  
Marzieh Ghane Ezabadi ◽  
Vahid Rakhshandeh
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Survival Rate ◽  
Liver Cancer ◽  
Significant Relationship ◽  
Cox Regression ◽  
Disease Risk ◽  
Cross Sectional ◽  
Common Cancer ◽  
History Of

Objectives: Liver cancer is one of the five most common cancer and the second leading cause of cancer death in men worldwide and the seventh most common cancer and the sixth leading cause of death in women from cancers. Liver cancer was the tenth most common cancer in Yazd in 1388 to 19% in women and 26% of males that has been more prevalent than in other provincial capitals. Methods: This cross-sectional descriptive study is a census of patients with hepatocellular carcinoma who referred to Yazd hospital pathology centers. All samples that have complete data from 1390 to 1394 were enrolled in the study. Information including age, sex, method of treatment and numbers of patients collected and then analyzed using statistical software spss 16 is placed. The aim of this study was to determine the survival rate of liver cancer patients according to age, sex, treatment, race and disease risk factors. Results: Of the 48 patients, 47.9% were female and 52.1% male during the five years . the average of age in this study was 62.81years. of the patients studied was 62.81 years .93.8% of patients were Iranian race. In this study, median survival was 7.43 months. The diabetes melitus with a prevalence of 18.8% was most common among the risk factors. alcohol consumption and the prevalence of hepatitis C has the lowest prevalence that was 1.9%. 83% of patients in this study were treated but other don’t come satisfaction for any treatment. Conclusion: In this study, like other studies, the incidence of liver cancer in men was higher than women. Most were Iranian people and the relationship between race and survival was no significant relationship between age, type of treatment, such as surgery, radiotherapy or chemotherapy with survival rate was not significant. But after Cox regression between age, family history of liver cancer, diabetes and treatment with survival in patients with hepatocellular carcinoma, there was a significant relationship. Keywords: HCC, Yazd, Survival

Xyloglucan as a mitomycin C carrier to reverse multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (109) ◽  
pp. 107800-107809 ◽  
Author(s):  
Chang Wang ◽  
Jean Felix Mukerabigwi ◽  
Shiying Luo ◽  
Yuannian Zhang ◽  
Xuan Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Developing Countries ◽  
Multidrug Resistance ◽  
Mitomycin C ◽  
Cancer Death ◽  
The Third

Hepatocellular carcinoma (HCC) is still considered as the third highest cause of cancer death in developing countries.

Increasing Incidence of Intrahepatic Cholangiocarcinoma and its Relationship to Chronic Viral Hepatitis

2009 ◽  
Vol 7 (4) ◽  
pp. 423-427 ◽  
Author(s):  
Kwang-Yu Chang ◽  
Jang-Yang Chang ◽  
Yun Yen
Keyword(s):  
Intrahepatic Cholangiocarcinoma ◽  
Viral Infections ◽  
Primary Liver Cancer ◽  
Chronic Viral Hepatitis ◽  
Cancer Death ◽  
Common Cause ◽  
Primary Liver Tumor ◽  
Common Cancer ◽  
The Relationship

Primary liver cancer is the sixth most common cancer and third most common cause of cancer death worldwide. Cholangiocarcinoma is the second most common primary liver tumor after hepatocellular carcinoma. Because the incidence of intrahepatic cholangiocarcinoma is rising in most areas worldwide, identification of the main causes of this problem is urgently needed. Despite well-known risk factors in the development of intrahepatic cholangiocarcinoma, recent reports focus on chronic hepatitis B and C viral infections because an increasing number of studies have observed an association. The relationship, however, is still not conclusive because of the diversity in clinical reports and the lack of in vitro evidences. This issue should be emphasized and further investigation is required for clarification.

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