Xyloglucan as a mitomycin C carrier to reverse multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (109) ◽  
pp. 107800-107809 ◽  
Author(s):  
Chang Wang ◽  
Jean Felix Mukerabigwi ◽  
Shiying Luo ◽  
Yuannian Zhang ◽  
Xuan Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Developing Countries ◽  
Multidrug Resistance ◽  
Mitomycin C ◽  
Cancer Death ◽  
The Third

Hepatocellular carcinoma (HCC) is still considered as the third highest cause of cancer death in developing countries.

Advances in delivery vectors for gene therapy in liver cancer

2020 ◽  
Vol 11 (1) ◽  
pp. 833-850 ◽  
Author(s):  
Katherine E Redd Bowman ◽  
Phong Lu ◽  
Erica R Vander Mause ◽  
Carol S Lim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Therapy ◽  
Viral Vectors ◽  
Gene Editing ◽  
Cancer Death ◽  
Common Cause ◽  
The Third ◽  
Gene Delivery Vectors ◽  
Efficient Delivery ◽  
Therapy Delivery

Hepatocellular carcinoma (HCC) is the third most common cause of cancer death globally, mainly due to lack of effective treatments – a problem that gene therapy is poised to solve. Successful gene therapy requires safe and efficient delivery vectors, and recent advances in both viral and nonviral vectors have made an important impact on HCC gene therapy delivery. This review explores how adenoviral, retroviral and adeno-associated viral vectors have been modified to increase safety and delivery capacity, highlighting studies and clinical trials using these vectors for HCC gene therapy. Nanoparticles, liposomes, exosomes and virosomes are also featured in their roles as HCC gene delivery vectors. Finally, new discoveries in gene editing technology and their impacts on HCC gene therapy are discussed.

scholarly journals Abdominal Ultrasound and Treatment of Hepatocellular Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1268
Author(s):  
Kazushi Numata
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Abdominal Ultrasound ◽  
Cancer Death ◽  
Common Cause ◽  
Cancer Statistics ◽  
The Third ◽  
Common Cancer

Liver cancer is the sixth most common cancer and the third most common cause of cancer death, based on Global Cancer Statistics 2020 [...]

Health Informatics Education in the Third World

1989 ◽  
Vol 28 (04) ◽  
pp. 270-272 ◽  
Author(s):  
O. Rienhoff
Keyword(s):  
Developing Countries ◽  
Health Informatics ◽  
Third World ◽  
State Of The Art ◽  
The State ◽  
Collaboration Network ◽  
Educational Tools ◽  
The Third ◽  
The Third World

Abstract:The state of the art is summarized showing many efforts but only few results which can serve as demonstration examples for developing countries. Education in health informatics in developing countries is still mainly dealing with the type of health informatics known from the industrialized world. Educational tools or curricula geared to the matter of development are rarely to be found. Some WHO activities suggest that it is time for a collaboration network to derive tools and curricula within the next decade.

scholarly journals NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Shin Maeda
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathways ◽  
Inflammatory Cell ◽  
Prognostic Markers ◽  
Tumor Promotion ◽  
Neoplastic Cell ◽  
Nuclear Factor ◽  
Tlr Signaling ◽  
The Third

Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-κB and JNKs, is critical for tumor organization. JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.

Social Research in Developing Countries: Surveys and Censuses in The Third World.

1987 ◽  
Vol 16 (1) ◽  
pp. 104
Author(s):  
Kenneth D. Bailey ◽  
Martin Bulmer ◽  
Donald P. Warwick
Keyword(s):  
Developing Countries ◽  
Third World ◽  
Social Research ◽  
The Third ◽  
The Third World

The Third Generation of Real-Time Virtual Sonography for Navigation in the Treatment of Hepatocellular Carcinoma

2011 ◽  
Vol 37 (8) ◽  
pp. S136
Author(s):  
Y. Eso ◽  
A. Sakamoto ◽  
S.G. Kim ◽  
S. Saito ◽  
H. Nishikawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Real Time ◽  
Third Generation ◽  
The Third

Lenvatinib and Cu2-XS nanocrystals co-encapsulated in poly(D,L-lactide-co-glycolide) for synergistic chemo-photothermal therapy against advanced hepatocellular carcinoma

2021 ◽  
Author(s):  
Qi Xu ◽  
Qiuting Li ◽  
Zhe Yang ◽  
Piao Huang ◽  
Han Hu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multidrug Resistance ◽  
Photothermal Therapy ◽  
Advanced Hepatocellular Carcinoma ◽  
Anticancer Effect ◽  
Targeted Drug ◽  
Low Cytotoxicity

Lenvatinib (LT) is gradually replacing sorafenib as an alternative targeted drug for advanced hepatocellular carcinoma (HCC). However, the anticancer effect of LT is still limited by low cytotoxicity, multidrug resistance...

Rethinking Public Health Pedagogy in Muslim Countries Postcolonially

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Raudah Mohd Yunus ◽  
Md. Mahmudul Hasan ◽  
Nurul Yaqeen Mohd Esa
Keyword(s):  
Public Health ◽  
Developing Countries ◽  
Critical Analysis ◽  
Pedagogical Practices ◽  
Educational Model ◽  
Modern Education ◽  
The Third ◽  
Muslim Countries ◽  
History Of ◽  
Three Stages

This article discusses the history of modern education in developing countries and attempts to look at Public Health (PH) education and curriculum from a Muslim and postcolonial perspective. It argues that, since modern PH pedagogical practices in Muslim countries are derived almost entirely from the western educational model and paradigm, they need reconstruction mainly for compatibility and relevance checks. The reconstruction of PH that this paper proposes aims at complementing and enriching the existing syllabi and involves three stages: fundamental, intermediate and advanced. In the first stage, students are equipped with a strong foundation of western and Islamic philosophies; the second one involves the incorporation of Islamic principles into the existing PH curriculum; while the third entails a critical analysis and deconstruction of some PH concepts and approaches in order to nurture students’ creativity in solving complex, emerging problems in the light of Islamic teachings as well as the need of Muslim sociocultural settings.

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