scholarly journals Generation of Synthetic Chest X-ray Images and Detection of COVID-19: A Deep Learning Based Approach

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 895
Author(s):  
Yash Karbhari ◽  
Arpan Basu ◽  
Zong-Woo Geem ◽  
Gi-Tae Han ◽  
Ram Sarkar
Keyword(s):  
Deep Learning ◽  
Distress Syndrome ◽  
Harmony Search ◽  
Nasal Discharge ◽  
X Rays ◽  
Generative Adversarial Network ◽  
Radiographic Images ◽  
X Ray ◽  
Adversarial Network ◽  
Chest X Ray

COVID-19 is a disease caused by the SARS-CoV-2 virus. The COVID-19 virus spreads when a person comes into contact with an affected individual. This is mainly through drops of saliva or nasal discharge. Most of the affected people have mild symptoms while some people develop acute respiratory distress syndrome (ARDS), which damages organs like the lungs and heart. Chest X-rays (CXRs) have been widely used to identify abnormalities that help in detecting the COVID-19 virus. They have also been used as an initial screening procedure for individuals highly suspected of being infected. However, the availability of radiographic CXRs is still scarce. This can limit the performance of deep learning (DL) based approaches for COVID-19 detection. To overcome these limitations, in this work, we developed an Auxiliary Classifier Generative Adversarial Network (ACGAN), to generate CXRs. Each generated X-ray belongs to one of the two classes COVID-19 positive or normal. To ensure the goodness of the synthetic images, we performed some experimentation on the obtained images using the latest Convolutional Neural Networks (CNNs) to detect COVID-19 in the CXRs. We fine-tuned the models and achieved more than 98% accuracy. After that, we also performed feature selection using the Harmony Search (HS) algorithm, which reduces the number of features while retaining classification accuracy. We further release a GAN-generated dataset consisting of 500 COVID-19 radiographic images.

scholarly journals RANDGAN: Randomized generative adversarial network for detection of COVID-19 in chest X-ray

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saman Motamed ◽  
Patrik Rogalla ◽  
Farzad Khalvati
Keyword(s):  
Health Care ◽  
Medical Images ◽  
Health Care Systems ◽  
Generative Adversarial Networks ◽  
X Rays ◽  
Generative Adversarial Network ◽  
X Ray ◽  
Adversarial Network ◽  
Care Systems ◽  
Chest X Ray

AbstractCOVID-19 spread across the globe at an immense rate and has left healthcare systems incapacitated to diagnose and test patients at the needed rate. Studies have shown promising results for detection of COVID-19 from viral bacterial pneumonia in chest X-rays. Automation of COVID-19 testing using medical images can speed up the testing process of patients where health care systems lack sufficient numbers of the reverse-transcription polymerase chain reaction tests. Supervised deep learning models such as convolutional neural networks need enough labeled data for all classes to correctly learn the task of detection. Gathering labeled data is a cumbersome task and requires time and resources which could further strain health care systems and radiologists at the early stages of a pandemic such as COVID-19. In this study, we propose a randomized generative adversarial network (RANDGAN) that detects images of an unknown class (COVID-19) from known and labelled classes (Normal and Viral Pneumonia) without the need for labels and training data from the unknown class of images (COVID-19). We used the largest publicly available COVID-19 chest X-ray dataset, COVIDx, which is comprised of Normal, Pneumonia, and COVID-19 images from multiple public databases. In this work, we use transfer learning to segment the lungs in the COVIDx dataset. Next, we show why segmentation of the region of interest (lungs) is vital to correctly learn the task of classification, specifically in datasets that contain images from different resources as it is the case for the COVIDx dataset. Finally, we show improved results in detection of COVID-19 cases using our generative model (RANDGAN) compared to conventional generative adversarial networks for anomaly detection in medical images, improving the area under the ROC curve from 0.71 to 0.77.

scholarly journals Accessory pathway analysis using a multimodal deep learning model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Makoto Nishimori ◽  
Kunihiko Kiuchi ◽  
Kunihiro Nishimura ◽  
Kengo Kusano ◽  
Akihiro Yoshida ◽  
...  
Keyword(s):  
Deep Learning ◽  
Electrophysiological Study ◽  
Accessory Pathway ◽  
Learning Model ◽  
X Rays ◽  
X Ray ◽  
Wpw Syndrome ◽  
Chest X Ray ◽  
Deep Learning Model ◽  
Ecg Data

AbstractCardiac accessory pathways (APs) in Wolff–Parkinson–White (WPW) syndrome are conventionally diagnosed with decision tree algorithms; however, there are problems with clinical usage. We assessed the efficacy of the artificial intelligence model using electrocardiography (ECG) and chest X-rays to identify the location of APs. We retrospectively used ECG and chest X-rays to analyse 206 patients with WPW syndrome. Each AP location was defined by an electrophysiological study and divided into four classifications. We developed a deep learning model to classify AP locations and compared the accuracy with that of conventional algorithms. Moreover, 1519 chest X-ray samples from other datasets were used for prior learning, and the combined chest X-ray image and ECG data were put into the previous model to evaluate whether the accuracy improved. The convolutional neural network (CNN) model using ECG data was significantly more accurate than the conventional tree algorithm. In the multimodal model, which implemented input from the combined ECG and chest X-ray data, the accuracy was significantly improved. Deep learning with a combination of ECG and chest X-ray data could effectively identify the AP location, which may be a novel deep learning model for a multimodal model.

scholarly journals Detecting Coronavirus from Chest X-rays Using Transfer Learning

COVID ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 403-415
Author(s):  
Abeer Badawi ◽  
Khalid Elgazzar
Keyword(s):  
Deep Learning ◽  
Binary Classification ◽  
Healthcare Providers ◽  
Large Set ◽  
X Rays ◽  
Learning Models ◽  
X Ray ◽  
Chest X Ray ◽  
Multi Class Classification ◽  
Novel Coronavirus

Coronavirus disease (COVID-19) is an illness caused by a novel coronavirus family. One of the practical examinations for COVID-19 is chest radiography. COVID-19 infected patients show abnormalities in chest X-ray images. However, examining the chest X-rays requires a specialist with high experience. Hence, using deep learning techniques in detecting abnormalities in the X-ray images is presented commonly as a potential solution to help diagnose the disease. Numerous research has been reported on COVID-19 chest X-ray classification, but most of the previous studies have been conducted on a small set of COVID-19 X-ray images, which created an imbalanced dataset and affected the performance of the deep learning models. In this paper, we propose several image processing techniques to augment COVID-19 X-ray images to generate a large and diverse dataset to boost the performance of deep learning algorithms in detecting the virus from chest X-rays. We also propose innovative and robust deep learning models, based on DenseNet201, VGG16, and VGG19, to detect COVID-19 from a large set of chest X-ray images. A performance evaluation shows that the proposed models outperform all existing techniques to date. Our models achieved 99.62% on the binary classification and 95.48% on the multi-class classification. Based on these findings, we provide a pathway for researchers to develop enhanced models with a balanced dataset that includes the highest available COVID-19 chest X-ray images. This work is of high interest to healthcare providers, as it helps to better diagnose COVID-19 from chest X-rays in less time with higher accuracy.

scholarly journals An Effective Convolutional Neural Network Model for the Early Detection of COVID-19 Using Chest X-ray Images

2021 ◽  
Vol 11 (21) ◽  
pp. 10301
Author(s):  
Muhammad Shoaib Farooq ◽  
Attique Ur Rehman ◽  
Muhammad Idrees ◽  
Muhammad Ahsan Raza ◽  
Jehad Ali ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Real World ◽  
Early Stage ◽  
Binary Classification ◽  
X Rays ◽  
X Ray ◽  
Proposed Model ◽  
Chest X Ray

COVID-19 has been difficult to diagnose and treat at an early stage all over the world. The numbers of patients showing symptoms for COVID-19 have caused medical facilities at hospitals to become unavailable or overcrowded, which is a major challenge. Studies have recently allowed us to determine that COVID-19 can be diagnosed with the aid of chest X-ray images. To combat the COVID-19 outbreak, developing a deep learning (DL) based model for automated COVID-19 diagnosis on chest X-ray is beneficial. In this research, we have proposed a customized convolutional neural network (CNN) model to detect COVID-19 from chest X-ray images. The model is based on nine layers which uses a binary classification method to differentiate between COVID-19 and normal chest X-rays. It provides COVID-19 detection early so the patients can be admitted in a timely fashion. The proposed model was trained and tested on two publicly available datasets. Cross-dataset studies are used to assess the robustness in a real-world context. Six hundred X-ray images were used for training and two hundred X-rays were used for validation of the model. The X-ray images of the dataset were preprocessed to improve the results and visualized for better analysis. The developed algorithm reached 98% precision, recall and f1-score. The cross-dataset studies also demonstrate the resilience of deep learning algorithms in a real-world context with 98.5 percent accuracy. Furthermore, a comparison table was created which shows that our proposed model outperforms other relative models in terms of accuracy. The quick and high-performance of our proposed DL-based customized model identifies COVID-19 patients quickly, which is helpful in controlling the COVID-19 outbreak.

scholarly journals A Hybrid Capsule Network for Pneumonia Detection Using Image Augmentation Based on Generative Adversarial Network

2021 ◽  
Vol 38 (3) ◽  
pp. 619-627
Author(s):  
Kazim Firildak ◽  
Muhammed Fatih Talu
Keyword(s):  
Classification Accuracy ◽  
Data Augmentation ◽  
Model Parameters ◽  
Classification Problems ◽  
Generative Adversarial Network ◽  
X Ray ◽  
Discrimination Capability ◽  
Adversarial Network ◽  
Original Dataset ◽  
Chest X Ray

Pneumonia, featured by inflammation of the air sacs in one or both lungs, is usually detected by examining chest X-ray images. This paper probes into the classification models that can distinguish between normal and pneumonia images. As is known, trained networks like AlexNet and GoogleNet are deep network architectures, which are widely adopted to solve many classification problems. They have been adapted to the target datasets, and employed to classify new data generated through transfer learning. However, the classical architectures are not accurate enough for the diagnosis of pneumonia. Therefore, this paper designs a capsule network with high discrimination capability, and trains the network on Kaggle’s online pneumonia dataset, which contains chest X-ray images of many adults and children. The original dataset consists of 1,583 normal images, and 4,273 pneumonia images. Then, two data augmentation approaches were applied to the dataset, and their effects on classification accuracy were compared in details. The model parameters were optimized through five different experiments. The results show that the highest classification accuracy (93.91% even on small images) was achieved by the capsule network, coupled with data augmentation by generative adversarial network (GAN), using optimized parameters. This network outperformed the classical strategies.

scholarly journals COVIDScreen: Explainable deep learning framework for differential diagnosis of COVID-19 using chest X-Rays

2020 ◽  
Author(s):  
Rajeev Kumar Singh ◽  
Rohan Pandey ◽  
Rishie Nandhan Babu
Keyword(s):  
Deep Learning ◽  
Model Performance ◽  
Alternative Methods ◽  
Model Complexity ◽  
X Rays ◽  
Kappa Score ◽  
X Ray ◽  
Pruning Strategy ◽  
Chest X Ray ◽  
To Come

Abstract COVID-19 has emerged as a global crisis with unprecedented socio-economic challenges, jeopardizing our lives and livelihoods for years to come. The unavailability of vaccines for COVID-19 has rendered rapid testing of the population instrumental in order to contain the exponential rise in cases of infection. Shortage of RT-PCR test kits and delay in obtaining test results calls for alternative methods of rapid and reliable diagnosis. In this article, we propose a novel Deep Learning based solution to rapidly classify COVID -19 patient using chest X-Ray. The proposed solution uses image enhancement, image segmentation and employs a modified stacked ensemble model consisting of four CNN base-learners along with Naive Bayes as meta-learner to classify Chest X-Ray into three classes viz. COVID-19, Pneumonia and Normal. An effective pruning strategy as introduced in the proposed framework results in increased model performance, generalisability, and decreased model complexity. We incorporate explainability in our article by using Grad-CAM visualisation in order to establish trust in the medical AI system. Furthermore, we evaluate multiple state of the art GAN architectures and their ability to generate realistic synthetic samples of COVID-19 chest X-Rays to deal with limited numbers of training samples. The proposed solution significantly outperforms existing methods, with 98.67\% accuracy, 0.98 Kappa score, and F-1 scores of 100, 98, and 98 for COVID-19, Normal, and Pneumonia classes respectively on standard datasets. The proposed solution can be used as one element of patient evaluation along with gold standard clinical and laboratory testing.

scholarly journals Deep Learning for Screening COVID-19 using Chest X-Ray Images

2020 ◽  
Author(s):  
Sanhita Basu ◽  
Sushmita Mitra ◽  
Nilanjan Saha
Keyword(s):  
Deep Learning ◽  
Lung Parenchyma ◽  
Clinical Findings ◽  
Data Sets ◽  
X Rays ◽  
X Ray ◽  
Chest X Ray ◽  
Increasing Demand ◽  
Novel Coronavirus ◽  
Diverse Data

AbstractWith the ever increasing demand for screening millions of prospective “novel coronavirus” or COVID-19 cases, and due to the emergence of high false negatives in the commonly used PCR tests, the necessity for probing an alternative simple screening mechanism of COVID-19 using radiological images (like chest X-Rays) assumes importance. In this scenario, machine learning (ML) and deep learning (DL) offer fast, automated, effective strategies to detect abnormalities and extract key features of the altered lung parenchyma, which may be related to specific signatures of the COVID-19 virus. However, the available COVID-19 datasets are inadequate to train deep neural networks. Therefore, we propose a new concept called domain extension transfer learning (DETL). We employ DETL, with pre-trained deep convolutional neural network, on a related large chest X-Ray dataset that is tuned for classifying between four classes viz. normal, other_disease, pneumonia and Covid — 19. A 5-fold cross validation is performed to estimate the feasibility of using chest X-Rays to diagnose COVID-19. The initial results show promise, with the possibility of replication on bigger and more diverse data sets. The overall accuracy was measured as 95.3% ± 0.02. In order to get an idea about the COVID-19 detection transparency, we employed the concept of Gradient Class Activation Map (Grad-CAM) for detecting the regions where the model paid more attention during the classification. This was found to strongly correlate with clinical findings, as validated by experts.

scholarly journals A Deep Learning Approach to Detect COVID-19 Patients from Chest X-ray Images

AI ◽  
2020 ◽  
Vol 1 (3) ◽  
pp. 418-435
Author(s):  
Khandaker Haque ◽  
Ahmed Abdelgawad
Keyword(s):  
Deep Learning ◽  
World Health ◽  
X Rays ◽  
X Ray ◽  
Global Pandemic ◽  
Proposed Model ◽  
Dental Diseases ◽  
Chest X Ray ◽  
Artery Disease ◽  
Health Organization

Deep Learning has improved multi-fold in recent years and it has been playing a great role in image classification which also includes medical imaging. Convolutional Neural Networks (CNNs) have been performing well in detecting many diseases including coronary artery disease, malaria, Alzheimer’s disease, different dental diseases, and Parkinson’s disease. Like other cases, CNN has a substantial prospect in detecting COVID-19 patients with medical images like chest X-rays and CTs. Coronavirus or COVID-19 has been declared a global pandemic by the World Health Organization (WHO). As of 8 August 2020, the total COVID-19 confirmed cases are 19.18 M and deaths are 0.716 M worldwide. Detecting Coronavirus positive patients is very important in preventing the spread of this virus. On this conquest, a CNN model is proposed to detect COVID-19 patients from chest X-ray images. Two more CNN models with different number of convolution layers and three other models based on pretrained ResNet50, VGG-16 and VGG-19 are evaluated with comparative analytical analysis. All six models are trained and validated with Dataset 1 and Dataset 2. Dataset 1 has 201 normal and 201 COVID-19 chest X-rays whereas Dataset 2 is comparatively larger with 659 normal and 295 COVID-19 chest X-ray images. The proposed model performs with an accuracy of 98.3% and a precision of 96.72% with Dataset 2. This model gives the Receiver Operating Characteristic (ROC) curve area of 0.983 and F1-score of 98.3 with Dataset 2. Moreover, this work shows a comparative analysis of how change in convolutional layers and increase in dataset affect classifying performances.

scholarly journals Finding COVID-19 from Chest X-rays using Deep Learning on a Small Dataset

2020 ◽  
Author(s):  
Lawrence Hall ◽  
Dmitry Goldgof ◽  
Rahul Paul ◽  
Gregory M. Goldgof
Keyword(s):  
Deep Learning ◽  
Bacterial Pneumonia ◽  
False Negative ◽  
False Negative Rate ◽  
X Rays ◽  
Test Results ◽  
X Ray ◽  
Chest X Ray ◽  
Small Dataset ◽  
Children Under 5

<p>Testing for COVID-19 has been unable to keep up with the demand. Further, the false negative rate is projected to be as high as 30% and test results can take some time to obtain. X-ray machines are widely available and provide images for diagnosis quickly. This paper explores how useful chest X-ray images can be in diagnosing COVID-19 disease. We have obtained 122 chest X-rays of COVID-19 and over 4,000 chest X-rays of viral and bacterial pneumonia. Unfortunately, we missed the fact that the chest X-rays of viral and bacterial pneumonia came from children under 5 years old. So, this work shows that you can tell kids with pneumonia from COVID-19 adult cases which is not anyone's goal. However, data from adult chest X-rays of other causes of lung disease is needed to see if you can tell adult diseases apart.<br></p>

scholarly journals Deep Mining Generation of Lung Cancer Malignancy Models from Chest X-ray Images

Sensors ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 6655
Author(s):  
Michael Horry ◽  
Subrata Chakraborty ◽  
Biswajeet Pradhan ◽  
Manoranjan Paul ◽  
Douglas Gomes ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Computer Vision ◽  
Deep Learning ◽  
Decision Tree ◽  
Decision Trees ◽  
Lung Nodules ◽  
X Rays ◽  
Learning Models ◽  
X Ray ◽  
Chest X Ray

Lung cancer is the leading cause of cancer death and morbidity worldwide. Many studies have shown machine learning models to be effective in detecting lung nodules from chest X-ray images. However, these techniques have yet to be embraced by the medical community due to several practical, ethical, and regulatory constraints stemming from the “black-box” nature of deep learning models. Additionally, most lung nodules visible on chest X-rays are benign; therefore, the narrow task of computer vision-based lung nodule detection cannot be equated to automated lung cancer detection. Addressing both concerns, this study introduces a novel hybrid deep learning and decision tree-based computer vision model, which presents lung cancer malignancy predictions as interpretable decision trees. The deep learning component of this process is trained using a large publicly available dataset on pathological biomarkers associated with lung cancer. These models are then used to inference biomarker scores for chest X-ray images from two independent data sets, for which malignancy metadata is available. Next, multi-variate predictive models were mined by fitting shallow decision trees to the malignancy stratified datasets and interrogating a range of metrics to determine the best model. The best decision tree model achieved sensitivity and specificity of 86.7% and 80.0%, respectively, with a positive predictive value of 92.9%. Decision trees mined using this method may be considered as a starting point for refinement into clinically useful multi-variate lung cancer malignancy models for implementation as a workflow augmentation tool to improve the efficiency of human radiologists.

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