scholarly journals Acute Labyrinthitis Revealing COVID-19

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 482
Author(s):  
Marie Perret ◽  
Angélique Bernard ◽  
Alan Rahmani ◽  
Patrick Manckoundia ◽  
Alain Putot
Keyword(s):  
Acute Otitis Media ◽  
Semicircular Canals ◽  
Nasopharyngeal Swab ◽  
Resonance Imaging ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Cerebral Magnetic Resonance Imaging ◽  
Reactive Protein ◽  
Polymerase Chain ◽  
Rotational Vertigo

An 84-year-old man presented to the emergency department for acute vomiting associated with rotational vertigo and a sudden right sensorineural hearing loss. A left peripheral vestibular nystagmus was highlighted. The patient was afebrile, without respiratory signs or symptoms. Blood sampling at admission showed lymphopenia, thrombopenia and neutrophil polynucleosis, without elevation of C reactive protein. Cerebral magnetic resonance imaging eliminated a neurovascular origin. Vestibule, right semicircular canals and cochlear FLAIR hypersignals were highlighted, leading to the diagnosis of right labyrinthitis. A nasopharyngeal swab sampled at admission returned positive for SARS CoV2 by polymerase chain reaction. The etiologic investigation, including syphilitic and viral research, was otherwise negative. An oral corticotherapy (prednisone 70 mg daily) was introduced, followed by a progressive clinical recovery. Although acute otitis media have already been highlighted as an unusual presentation of COVID-19, radiology-proven labyrinthitis had to our knowledge, never been described to date.

scholarly journals Experience with the use of siltuximab in patients with SARS-CoV-2 infection

2021 ◽  
Author(s):  
Fernanda Meira ◽  
Laia Albiach ◽  
Cristina Carbonell ◽  
José-Ángel Martín-Oterino ◽  
Mercedes Martín-Ordiales ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Nasopharyngeal Swab ◽  
C Reactive Protein ◽  
Median Dose ◽  
First Line ◽  
Chain Reaction ◽  
Positive Polymerase Chain Reaction ◽  
Reactive Protein ◽  
Polymerase Chain ◽  
Hospital Clinic

Objectives. The study aims to describe characteristics and clinical outcome of patients with SARS-CoV-2 infection that received siltuximab according to a protocol that aimed to early block the activity of IL-6 to avoid the progression of the inflammatory flare. Patients and methods. Retrospective review of the first 31 patients with SARS-CoV-2 treated with siltuximab, in Hospital Clinic of Barcelona or Hospital Universitario Salamanca, from March to April 2020 with positive polymerase-chain reaction (PCR) from a nasopharyngeal swab. Results. The cohort included 31 cases that received siltuximab with a median (IQR) age of 62 (56-71) and 71% were males. The most frequent comorbidity was hypertension (48%). The median dose of siltuximab was 800 mg ranging between 785 and 900 mg. 7 patients received siltuximab as a salvage therapy after one dose of tocilizumab. At the end of the study, a total of 26 (83.9) patients had been discharged alive and the mortality rate was 16.1% but only 1 out of 24 that received siltuximab as a first line option (4%). Conclusions. Siltuximab is a well-tolerated alternative to tocilizumab when administered as a first line option in patients with COVID-19 pneumonia within the first 10 days from symptoms onset and high C-reactive protein.

scholarly journals Uji Diagnostik C-Reactive Protein pada Pneumonia Bakteri Komunitas Anak

Sari Pediatri ◽  
2016 ◽  
Vol 17 (5) ◽  
pp. 391
Author(s):  
Ikhsan Marzony ◽  
Finny Fitry Yani ◽  
Efrida Efrida
Keyword(s):  
Polymerase Chain Reaction ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Polymerase Chain

Latar belakang. Polymerase chain reaction (PCR) merupakan teknik untuk menentukan agen penyebab pneumonia dengan sensitivitas dan spesifisitas yang tinggi, tetapi harganya mahal dan tidak tersedia di semua tempat. C-reactive protein (CRP) juga dapat digunakan untuk memprediksi infeksi bakteri dan memiliki keunggulan yang lain, yakni harganya yang murah dan hampir tersedia di semua laboratorium.Tujuan. Mengetahui sensitivitas, spesifisitas, nilai prediksi positif, dan nilai prediksi negatif CRP pada pneumonia bakteri komunitas anak.Metode. Penelitian cross sectional pada 62 subjek di Bagian Ilmu Kesehatan Anak RS. Dr. M. Djamil Padang dari Desember 2013 sampai Oktober 2014. Subjek dipilih dengan teknik konsekutif. Dilakukan uji CRP dan teknik PCR sebagai baku emas. Duapuluh tiga sampel diekslusi karena menderita penyakit jantung bawaan (7), sepsis (6), telah mendapatkan antibiotik (4), dan orang tua menolak pemeriksaan (6) sehingga total sampel menjadi 39 anak.Hasil. Sebagian besar subjek penelitian adalah laki-laki (59%) dan kelompok umur terbanyak 2-11 bulan (48,7%). Sensitivitas CRP dengan cut off point 8 mg/L adalah 51,6%, spesifisitas 75%, nilai prediksi positif 88,8%, nilai prediksi negatif 28,6%. Pada cut off point 10 mg/L, sensitivitas CRP adalah 41,9%, spesifisitas 87,5%, nilai prediksi positif 92,9%, nilai prediksi negatif 28%.Kesimpulan. C-reactive protein tidak dapat digunakan sebagai uji tapis terhadap pneumonia bakteri komunitas anak.

scholarly journals DETERMINATION OF DIAGNOSTIC ACCURACY OF BIOCHEMICAL PARAMETERS (CRP, LDH & FERRITIN) IN THE DIAGNOSIS OF COVID-19 IN SUSPECTED COVID CASES

2021 ◽  
Vol 71 (5) ◽  
pp. 1722-26
Author(s):  
Tayyaba Ashiq ◽  
Abdus Sattar ◽  
Nasir Uddin ◽  
Qamar Bashir ◽  
Sajida Shaheen ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Lactate Dehydrogenase ◽  
Diagnostic Accuracy ◽  
Biochemical Parameters ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Reactive Protein ◽  
Poor Predictor ◽  
Lactate Dehydrogenase C ◽  
Polymerase Chain

Objective: To determine the diagnostic accuracy of the Lactate Dehydrogenase, C-Reactive Protein and Ferritin in suspected patients of COVID-19. Study Design: Cross-sectional validation study. Place and Duration of Study: Pathology department of Combined Military Hospital Lahore in the month of May 2020. Methodology: We included 101 adult (>18 years) symptomatic suspected COVID-19 patients of both genders. Children, pregnant women and asymptomatic patients were excluded from study. Age, gender and results of Reverse Transcriptase Polymerase Chain Reaction, Lactate Dehydrogenase, C-Reactive Protein, ferritin were recorded. Results: Lactate Dehydrodenase had highest sensitivity (75%) with positive predictive value of 71.6% and diagnostic accuracy of 65.3% among three biochemical parameters studied. Receiver Operator Characteristic curve was studied. Area under curve of Lactate Dehydrogenase (AUC=0.65) and Ferritin (AUC=0.59) reflected their ability to prognosticate the presence of COVID19 disease. However, C-Reactive Protein (AUC=0.42) appeared to be a poor predictor of the disease. Conclusion: Raised serum Lactate Dehydrogenase (>490 U/L) and Ferritin (>152 ng/L) levels can be used to predict the Reverse Transcriptase Polymerase Chain Reaction positivity for COVID-19 in the population of suspected patients of COVID19. However, C-Reactive Protein is a poor predictor of COVID-19.

Herpes simplex encephalitis after craniopharyngioma surgery

2008 ◽  
Vol 2 (5) ◽  
pp. 355-358 ◽  
Author(s):  
Ji-Woong Kwon ◽  
Byung-Kyu Cho ◽  
Eui Chong Kim ◽  
Kyu-Chang Wang ◽  
Seung-Ki Kim
Keyword(s):  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Ct Scanning ◽  
High Dose ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Reactive Protein ◽  
Serial Ct ◽  
Polymerase Chain ◽  
Simplex Virus

A 13-year-old girl exhibited rapid deterioration in mental status 15 days after surgery for craniopharyngioma. Serial CT scanning detected progression of a low-density lesion on the left frontotemporal lobe. The serum level of C-reactive protein was elevated and polymerase chain reaction identified herpes simplex virus DNA in the cerebrospinal fluid. Antiviral therapy with high-dose acyclovir (10 mg/kg 3 times daily) was begun. She recovered and could speak short sentences, but dysphasia and right hemiparesis remained. Early diagnosis and active treatment of herpes simplex encephalitis is essential for improving prognosis and saving lives.

scholarly journals Assessment of Serum L-Ficolin Level as Inflammatory Marker and Its Correlation with Serum C-Reactive Protein, D-Dimer and Ferritin in a Sample of Iraqi COVID-19 Patients

2021 ◽  
Vol 23 (08) ◽  
pp. 107-116
Author(s):  
Layth Taha Abdulhussein ◽  
◽  
Dr. Mohammed Abdullatif ◽  
Dr. Aref Sami Malik ◽  
◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Reverse Transcriptase ◽  
Disease Stage ◽  
Viral Gene ◽  
Upper Respiratory Tract ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Reactive Protein ◽  
Polymerase Chain ◽  
D Dimer

Subject: At the end of December 2019, a COVID-19 outbreak was reported for the first time in Wuhan, China. Which quickly expanded throughout China, then to 209 nations across America, Europe, Australia, and Asia. More than 50,000 people have died and over one million individuals have been afflicted worldwide, with the number fast rising. COVID-19 has been combated in various ways around the world. The gold standard for COVID-19 diagnosis is real-time fluorescence quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase-polymerase chain reaction, RT-PCR) and viral gene sequencing. Currently, nasopharyngeal swabs from the upper respiratory tract are the most commonly employed nucleic acid detection samples. Objective of the Study: To estimate the level of ficolin in covid-19 patient in moderate and severe disease stage determination (series measurement and follow up) and find the diagnostic tool to early detect the virus to minimize the severity of the disease and further complication. Correlation of serum L-ficolin concentrations with Serum C-Reactive Protein, D-Dimer and Ferritin also to find Prognostic value of L-ficolin will be studied by corelating the treatment outcomes over one month with the three initial L-ficolin level. Materials and Methods: Sixty-two patients will be involved in the study from both sex male and female and different age group (18-80 yr.), the basal level of ficolin will be measure at time of admission of patient (time zero), then further serial measurement will be done on day 7 of admission for precise ficolin monitoring. Results: This study shows elevation of serum L-Ficolin level in survival and non-survival group. Conclusion: The results showed significant negative correlation between L-ficolin levels with the duration of illness (r = -0.377, p =0.020), however there were no significant correlation between L-ficolin levels with other patient‟s parameters.

scholarly journals Prognostic factors in spanish COVID-19 patients: A case series from barcelona

2020 ◽  
Author(s):  
Antoni Sisó-Almirall ◽  
Belchin Kostov ◽  
Minerva Mas-Heredia ◽  
Sergi Vilanova-Rotllan ◽  
Ethel Sequeira-Aymar ◽  
...  
Keyword(s):  
Medical Records ◽  
Case Series ◽  
Low Oxygen ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Reactive Protein ◽  
Low Platelet Count ◽  
Male Sex ◽  
Polymerase Chain ◽  
Elevated Lactate

ABSTRACTBackgroundIn addition to the lack of COVID-19 diagnostic tests for the whole Spanish population, the current strategy is to identify the disease early to limit contagion in the community.AimTo determine clinical factors of a poor prognosis in patients with COVID-19 infection.Design and SettingDescriptive, observational, retrospective study in three primary healthcare centres with an assigned population of 100,000.MethodExamination of the medical records of patients with COVID-19 infections confirmed by polymerase chain reaction.ResultsWe included 322 patients (mean age 56.7 years, 50% female, 115 (35.7%) aged ≥ 65 years). The best predictors of ICU admission or death were greater age, male sex (OR=2.99; 95%CI=1.55 to 6.01), fever (OR=2.18; 95%CI=1.06 to 4.80), dyspnoea(OR=2.22; 95%CI=1.14 to 4.24), low oxygen saturation (OR=2.94; 95%CI=1.34 to 6.42), auscultatory alterations (OR=2.21; 95%CI=1.00 to 5.29), heart disease (OR=4.37; 95%CI=1.68 to 11.13), autoimmune disease (OR=4.03; 95%CI=1.41 to 11.10), diabetes (OR=4.00; 95%CI=1.89 to 8.36), hypertension (OR=3.92; 95%CI=2.07 to 7.53), bilateral pulmonary infiltrates (OR=3.56; 95%CI=1.70 to 7.96), elevated lactate-dehydrogenase (OR=3.02; 95%CI=1.30 to 7.68), elevated C-reactive protein (OR=2.94; 95%CI=1.47 to 5.97), elevated D-dimer (OR=2.66; 95%CI=1.15 to 6.51) and low platelet count (OR=2.41; 95%CI=1.12 to 5.14). Myalgia or artralgia (OR=0.28; 95%CI=0.10 to 0.66), dysgeusia (OR=0.28; 95%CI=0.05 to 0.92) and anosmia (OR=0.23; 95%CI=0.04 to 0.75) were protective factors.ConclusionDetermining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection will be key to early treatment and isolation and the tracing of contacts.

scholarly journals Respiratory and non-respiratory manifestations in children admitted with COVID 19 in Rio de Janeiro city, Brazil

2021 ◽  
Author(s):  
AR Araujo da Silva ◽  
CGB Fonseca ◽  
JLPS Miranda ◽  
BV Travassos ◽  
CR Baião ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Length Of Stay ◽  
Respiratory Symptoms ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Serological Tests ◽  
Main Symptom ◽  
Reactive Protein ◽  
Polymerase Chain ◽  
Janeiro City

AbstractIntroductionCOVID 19 is still a challenge in pediatrics due to variety of symptoms and different presentationsAimTo describe clinical, laboratorial and treatment of confirmed COVID-19 pediatric admitted in hospitals.MethodsA retrospective study was conducted in children (0-18 years), admitted between March and November 15, 2020, with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Clinical data about symptoms, laboratorial exams and treatments were analysed. Patients were evaluated according predominant (PRS) or non-predominant respiratory symptoms (non-PRS)ResultsSixty-four patients were evaluated, being the median age 5.6 years. Forty-seven (73.4%) children were admitted with PRS and 17 (26.4%) with non-PRS. The main symptoms in the PRS group were fever in 74.5% of children and cough in 66%; and fever in 76.5% and edema/cavitary effusion in 29.4% in the non-PRS group. The median of C-reactive protein (in mg/dl) was 2.5 in the PRS group and 6.1 in the non-PRS group. Antibiotics were used in 85.1% of the PRS group and 94.1% of non-group. Comorbidity was present in 30/47 (63.8%) of PRS group and 8/17 (47.1%) of non-PRS group (p=0.22). Length of stay until 7 days in patients with comorbidity was present in 27/64 (42.1%) and more than 7 days in 11/64 (17.1%) (p= 0.2)ConclusionNon-PRS represented more than one quarter of admitted patients. Fever was the main symptom detected, elevated CRP was frequent and antibiotics were commonly prescribed. Comorbidity was found in both groups and his presence was not associated with a longer length of stay.

scholarly journals Subcorneal Pustular Dermatosis with Temporary Autoimmune Features during COVID-19 Pandemic

2020 ◽  
Vol 8 (T1) ◽  
pp. 12-15
Author(s):  
Uwe Wollina ◽  
André Koch ◽  
Gesina Hansel ◽  
Caroline Fürll ◽  
Jacqueline Schönlebe
Keyword(s):  
Inflammatory Infiltrate ◽  
Antinuclear Antibodies ◽  
Neutrophilic Dermatosis ◽  
Unknown Etiology ◽  
C Reactive Protein ◽  
Chain Reaction ◽  
Reactive Protein ◽  
Subcorneal Pustular Dermatosis ◽  
Laboratory Investigations ◽  
Polymerase Chain

Subcorneal pustular dermatosis, Sneddon-Wilkinson, is an uncommon neutrophilic dermatosis of unknown etiology. We report on a 51-year-old woman who presented with multiple superficial erythematous erosions surrounded by annular arranged sterile pustules concentrated on the trunk, the neck, and the proximal extremities during the coronavirus disease-19 pandemic. Larges pustules and flaccid bullae showed a hypopyon. There were no fever and no pruritus, general health was unaffected. Laboratory investigations revealed leukocytosis, neutrophilia, lymphopenia, and increased C-reactive protein. Initially, antinuclear antibodies, pemphigoid antibodies, and antibodies to BP 230 were positive, but negative 5 days later. Nasopharyngeal swabs were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA tested by real-time reverse-transcriptase-polymerase chain reaction. A diagnostic skin biopsy showed epidermal spongiotic vesiculation and subcorneal pustulation with acantholysis and an inflammatory infiltrate composed of neutrophils and lymphocytes. The confirmed diagnosis was subcorneal pustular dermatosis Sneddon-Wilkinson. She was treated by dapsone and corticosteroids with the latter tempered down. Clinical response was rapid. We suggest that the autoimmune features seen on admission may be due to an undefined viral infection, but not SARS-CoV-2.

scholarly journals Malacoplakia of the Uterine Cervix: A Case Report

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 343
Author(s):  
Adela Saco ◽  
Natalia Rakislova ◽  
Lorena Marimon ◽  
Aureli Torne ◽  
Berta Diaz-Feijoo ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Genital Tract ◽  
Vaginal Bleeding ◽  
Female Genital Tract ◽  
Granulomatous Inflammation ◽  
Resonance Imaging ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Cervical Tumors ◽  
Female Genital

Malacoplakia is an uncommon chronic granulomatous inflammation that rarely affects the female genital tract. A case of a 78-year-old woman with malacoplakia involving the uterine cervix and the vagina is described. The patient complained of vaginal bleeding. Clinically, a 13-mm mass was detected in the cervix, which was confirmed by ultrasound scan and magnetic resonance imaging. Histological examination showed a dense histiocytic infiltrate with abundant Michaelis–Gutmann bodies involving the uterine cervix and the upper vagina. The presence of Escherichia coli was confirmed in the lesion by immunohistochemistry and polymerase chain reaction. Only 12 cases of cervical malacoplakia have been reported to date. This condition should be included in the differential diagnosis of cervical tumors.

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