scholarly journals Circulating MicroRNAs in Blood and Other Body Fluids as Biomarkers for Diagnosis, Prognosis, and Therapy Response in Lung Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 421
Author(s):  
Luis Vicente Gayosso-Gómez ◽  
Blanca Ortiz-Quintero
Keyword(s):  
Lung Cancer ◽  
Clinical Application ◽  
Therapy Response ◽  
Body Fluids ◽  
Response To Treatment ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Non Invasive ◽  
Potential Value ◽  
Potential Clinical Application

The identification of circulating microRNAs (miRNAs) in peripheral blood and other body fluids has led to considerable research interest in investigating their potential clinical application as non-invasive biomarkers of cancer, including lung cancer, the deadliest malignancy worldwide. Several studies have found that alterations in the levels of miRNAs in circulation are able to discriminate lung cancer patients from healthy individuals (diagnosis) and are associated with patient outcome (prognosis) and treatment response (prediction). Increasing evidence indicates that circulating miRNAs may function as mediators of cell-to-cell communication, affecting biological processes associated with tumor initiation and progression. This review is focused on the most recent studies that provide evidence of the potential value of circulating miRNAs in blood and other body fluids as non-invasive biomarkers of lung cancer in terms of diagnosis, prognosis, and response to treatment. The status of their potential clinical application in lung cancer is also discussed, and relevant clinical trials were sought and are described. Because of the relevance of their biological characteristics and potential value as biomarkers, this review provides an overview of the canonical biogenesis, release mechanisms, and biological role of miRNAs in lung cancer.

Potential Clinical Application of Antioncogene Ribozymes for Human Lung Cancer

2001 ◽  
Vol 2 (3) ◽  
pp. 220-226 ◽  
Author(s):  
Alex W. Tong ◽  
Yu-An Zhang ◽  
Casey Cunningham ◽  
Phillip Maples ◽  
John Nemunaitis
Keyword(s):  
Lung Cancer ◽  
Clinical Application ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Potential Clinical Application

scholarly journals Circulating MicroRNAs as Potential Molecular Biomarkers in Pathophysiological Evolution of Pregnancy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dragos Cretoiu ◽  
Jiahong Xu ◽  
Junjie Xiao ◽  
Nicolae Suciu ◽  
Sanda Maria Cretoiu
Keyword(s):  
Small Rna ◽  
Eukaryotic Cells ◽  
Biological Processes ◽  
Recurrent Abortion ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Rna Molecules ◽  
Potential Value ◽  
Pregnancy Status ◽  
Implantation Period

MicroRNAs represent nonprotein coding small RNA molecules that are very stable to degradation and responsible for gene silencing in most eukaryotic cells. Increased evidence has been accumulating over the years about their potential value as biomarkers for several diseases. MicroRNAs were predicted to be involved in nearly all biological processes from development to oncogenesis. In this review, we address the importance of circulating microRNAs in different conditions associated with pregnancy starting with the implantation period to preeclampsia and we shortly describe the correlation between placental circulating miRNAs and pregnancy status. We also discuss the importance of microRNAs in recurrent abortion and ectopic pregnancy.

scholarly journals Biomarker development for non-invasive prenatal diagnosis of fetal aneuploidies: predictive reliability and potential clinical application

2011 ◽  
Vol 2 (2) ◽  
pp. 157-161
Author(s):  
Aggeliki Kolialexi ◽  
Athanasios K. Anagnostopoulos ◽  
Georgia Tounta ◽  
Aris Antsaklis ◽  
Ariadni Mavrou ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Clinical Application ◽  
Non Invasive ◽  
Potential Clinical Application ◽  
Fetal Aneuploidies

scholarly journals Circulating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers

2014 ◽  
Vol 128 (1) ◽  
pp. 1-15 ◽  
Author(s):  
Kirsten Lindner ◽  
Joerg Haier ◽  
Zhe Wang ◽  
David I. Watson ◽  
Damian J. Hussey ◽  
...  
Keyword(s):  
Tumour Progression ◽  
Expression Profiles ◽  
Clinical Applications ◽  
Current Evidence ◽  
Gastrointestinal Cancers ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Non Invasive ◽  
Diagnosis And Prognosis ◽  
Key Characteristics

To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumour and therefore might correlate with tumour progression and recurrence, and they are bound to proteins or contained in subcellular particles, such as microvesicles or exosomes, making them highly stable and resistant to degradation. The present review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications of circulating miRNAs for diagnostic and prognostic purposes.

Abstract 884: Circulating microRNAs as non-invasive biomarkers for early detection of lung cancer

2014 ◽  
Author(s):  
Magdalena B. Wozniak ◽  
Ghislaine Scelo ◽  
David Muller ◽  
Anush Moukeria ◽  
David Zaridze ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Circulating Micrornas ◽  
Non Invasive

Clinical application of postoperative non-invasive positive pressure ventilation after lung cancer surgery

2018 ◽  
Vol 66 (10) ◽  
pp. 565-572 ◽  
Author(s):  
Satoru Okada ◽  
Kazuhiro Ito ◽  
Junichi Shimada ◽  
Daishiro Kato ◽  
Masanori Shimomura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Application ◽  
Positive Pressure Ventilation ◽  
Lung Cancer Surgery ◽  
Cancer Surgery ◽  
Positive Pressure ◽  
Non Invasive

Circulating microRNAs as biomarkers in progressive multiple sclerosis

2016 ◽  
Vol 23 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Julia Vistbakka ◽  
Irina Elovaara ◽  
Terho Lehtimäki ◽  
Sanna Hagman
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cells ◽  
Progressive Multiple Sclerosis ◽  
Body Fluids ◽  
Primary Progressive Multiple Sclerosis ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Primary Progressive ◽  
Secondary Progressive ◽  
Exceptional Stability

Background: In multiple sclerosis (MS), microRNA (miRNA) dysregulation is mostly reported in different immune cells, but less information is available on circulating miRNAs that exert strong biomarker potential due to their exceptional stability in body fluids. Objective: The aim of this study was to profile expression of circulating miRNAs in primary progressive multiple sclerosis (PPMS) and secondary progressive multiple sclerosis (SPMS) and assess their association with neurological worsening. Methods: The expressions of 84 different miRNAs were profiled in serum of 83 subjects (62 MS and 21 controls) using miScript miRNA techniques. First, they were screened on 18 PPMS and 10 controls; thereafter, 10 most aberrantly expressed miRNAs were validated on a larger cohort. Results: In comparison with controls, upregulation of miR-191-5p was found in both progressive MS subtypes, while miR-376c-3p was overexpressed only in PPMS. Additionally, upregulation of miR-128-3p and miR-24-3p was detected in PPMS when compared to controls and SPMS. Progression index correlated with miR-128-3p in PPMS and miR-375 in SPMS. Conclusion: We detected overexpression of four miRNAs that have not been previously associated with progressive forms of MS. The increased expression of circulating miR-191-5p seems to be associated with progressive forms of MS, while miR-128-3p seems to be associated mostly with PPMS.

scholarly journals Circulating MicroRNAs as Non-Invasive Biomarkers for Early Detection of Non-Small-Cell Lung Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125026 ◽  
Author(s):  
Magdalena B. Wozniak ◽  
Ghislaine Scelo ◽  
David C. Muller ◽  
Anush Mukeria ◽  
David Zaridze ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Early Detection ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Circulating Micrornas ◽  
Non Invasive

scholarly journals Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes

2020 ◽  
Vol 10 (3) ◽  
pp. 98
Author(s):  
Veronica Zelli ◽  
Chiara Compagnoni ◽  
Roberta Capelli ◽  
Katia Cannita ◽  
Tina Sidoni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Potential Role ◽  
Molecular Subtypes ◽  
Therapeutic Strategies ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Non Invasive ◽  
Biological Features ◽  
Non Coding Rna

Breast cancer (BC) is a common and heterogeneous disease, of which six molecular subtypes, characterized by different biological features and clinical outcomes, were described. The identification of additional biomarkers able to further connote and distinguish the different BC subtypes is essential to improve the diagnostic, prognostic and therapeutic strategies in BC patients. MicroRNAs (miRNAs) are short non-coding RNA involved in several physiological and pathological processes, including cancer development and progression. In particular, circulating miRNAs, which can be found in an adequately stable structure in serum/plasma of cancer patients, are emerging as very promising non-invasive biomarkers. Several studies have analyzed the potential role of circulating miRNAs as prognostic and therapeutic markers in BC. In the present review we describe circulating miRNAs, identified as putative biomarker in BC, with special reference to different BC molecular subtypes.

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