scholarly journals MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 359 ◽  
Author(s):  
Omneya Attallah

Medulloblastoma (MB) is a dangerous malignant pediatric brain tumor that could lead to death. It is considered the most common pediatric cancerous brain tumor. Precise and timely diagnosis of pediatric MB and its four subtypes (defined by the World Health Organization (WHO)) is essential to decide the appropriate follow-up plan and suitable treatments to prevent its progression and reduce mortality rates. Histopathology is the gold standard modality for the diagnosis of MB and its subtypes, but manual diagnosis via a pathologist is very complicated, needs excessive time, and is subjective to the pathologists’ expertise and skills, which may lead to variability in the diagnosis or misdiagnosis. The main purpose of the paper is to propose a time-efficient and reliable computer-aided diagnosis (CADx), namely MB-AI-His, for the automatic diagnosis of pediatric MB and its subtypes from histopathological images. The main challenge in this work is the lack of datasets available for the diagnosis of pediatric MB and its four subtypes and the limited related work. Related studies are based on either textural analysis or deep learning (DL) feature extraction methods. These studies used individual features to perform the classification task. However, MB-AI-His combines the benefits of DL techniques and textural analysis feature extraction methods through a cascaded manner. First, it uses three DL convolutional neural networks (CNNs), including DenseNet-201, MobileNet, and ResNet-50 CNNs to extract spatial DL features. Next, it extracts time-frequency features from the spatial DL features based on the discrete wavelet transform (DWT), which is a textural analysis method. Finally, MB-AI-His fuses the three spatial-time-frequency features generated from the three CNNs and DWT using the discrete cosine transform (DCT) and principal component analysis (PCA) to produce a time-efficient CADx system. MB-AI-His merges the privileges of different CNN architectures. MB-AI-His has a binary classification level for classifying among normal and abnormal MB images, and a multi-classification level to classify among the four subtypes of MB. The results of MB-AI-His show that it is accurate and reliable for both the binary and multi-class classification levels. It is also a time-efficient system as both the PCA and DCT methods have efficiently reduced the training execution time. The performance of MB-AI-His is compared with related CADx systems, and the comparison verified the powerfulness of MB-AI-His and its outperforming results. Therefore, it can support pathologists in the accurate and reliable diagnosis of MB and its subtypes from histopathological images. It can also reduce the time and cost of the diagnosis procedure which will correspondingly lead to lower death rates.

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Manab Kumar Das ◽  
Samit Ari

Classification of electrocardiogram (ECG) signals plays an important role in clinical diagnosis of heart disease. This paper proposes the design of an efficient system for classification of the normal beat (N), ventricular ectopic beat (V), supraventricular ectopic beat (S), fusion beat (F), and unknown beat (Q) using a mixture of features. In this paper, two different feature extraction methods are proposed for classification of ECG beats: (i) S-transform based features along with temporal features and (ii) mixture of ST and WT based features along with temporal features. The extracted feature set is independently classified using multilayer perceptron neural network (MLPNN). The performances are evaluated on several normal and abnormal ECG signals from 44 recordings of the MIT-BIH arrhythmia database. In this work, the performances of three feature extraction techniques with MLP-NN classifier are compared using five classes of ECG beat recommended by AAMI (Association for the Advancement of Medical Instrumentation) standards. The average sensitivity performances of the proposed feature extraction technique for N, S, F, V, and Q are 95.70%, 78.05%, 49.60%, 89.68%, and 33.89%, respectively. The experimental results demonstrate that the proposed feature extraction techniques show better performances compared to other existing features extraction techniques.


2020 ◽  
Vol 17 (12) ◽  
pp. 5535-5542
Author(s):  
Purohit Om Hemantkumar ◽  
Rakshit Lodha ◽  
Meghna Bajoria ◽  
R. Sujatha

Pneumonia is an infection caused by bacteria and viruses. It can shift from mellow to serious cases. This disease causes severe damages to the lungs since they fill with fluids. This situation causes difficulty in breathing. It further prevents oxygen to reach the blood. Pneumonia is diagnosed with the help of a chest X-rays, which can also use in the diagnosis of diseases like emphysema, lung cancer, and tuberculosis. According to WHO (World Health Organization (WHO). 2001. Standardization of Interpretation of Chest Radiographs for the Diagnosis of Pneumonia in Children. p.4.), Chest X-rays, at present, is the best available method for detecting pneumonia. Feature extraction methods like DiscreteWavelet Transform (DWT),Wavelet Frame Transform (WFT), andWavelet Packet Transform (WPT) can be used followed by any classification algorithm. In this paper, models like Squeezenet, DenseNet, and Resnet34 have been used for image recognition. In our system, the medical images were taken from Kaggle database and were recorded using a suitable imaging system. The images retrieved were then considered for input for the system where the images go through the various phases of image processing like pre-processing, edge detection and feature extraction. Later, a variety of training models are applied to know which model offers the highest accuracy.


2020 ◽  
Vol 10 (20) ◽  
pp. 7068
Author(s):  
Minh Tuan Pham ◽  
Jong-Myon Kim ◽  
Cheol Hong Kim

Recent convolutional neural network (CNN) models in image processing can be used as feature-extraction methods to achieve high accuracy as well as automatic processing in bearing fault diagnosis. The combination of deep learning methods with appropriate signal representation techniques has proven its efficiency compared with traditional algorithms. Vital electrical machines require a strict monitoring system, and the accuracy of these machines’ monitoring systems takes precedence over any other factors. In this paper, we propose a new method for diagnosing bearing faults under variable shaft speeds using acoustic emission (AE) signals. Our proposed method predicts not only bearing fault types but also the degradation level of bearings. In the proposed technique, AE signals acquired from bearings are represented by spectrograms to obtain as much information as possible in the time–frequency domain. Feature extraction and classification processes are performed by deep learning using EfficientNet and a stochastic line-search optimizer. According to our various experiments, the proposed method can provide high accuracy and robustness under noisy environments compared with existing AE-based bearing fault diagnosis methods.


2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Amjed S. Al-Fahoum ◽  
Ausilah A. Al-Fraihat

Technically, a feature represents a distinguishing property, a recognizable measurement, and a functional component obtained from a section of a pattern. Extracted features are meant to minimize the loss of important information embedded in the signal. In addition, they also simplify the amount of resources needed to describe a huge set of data accurately. This is necessary to minimize the complexity of implementation, to reduce the cost of information processing, and to cancel the potential need to compress the information. More recently, a variety of methods have been widely used to extract the features from EEG signals, among these methods are time frequency distributions (TFD), fast fourier transform (FFT), eigenvector methods (EM), wavelet transform (WT), and auto regressive method (ARM), and so on. In general, the analysis of EEG signal has been the subject of several studies, because of its ability to yield an objective mode of recording brain stimulation which is widely used in brain-computer interface researches with application in medical diagnosis and rehabilitation engineering. The purposes of this paper, therefore, shall be discussing some conventional methods of EEG feature extraction methods, comparing their performances for specific task, and finally, recommending the most suitable method for feature extraction based on performance.


2021 ◽  
Vol 11 ◽  
Author(s):  
Hao Fu ◽  
Weiming Mi ◽  
Boju Pan ◽  
Yucheng Guo ◽  
Junjie Li ◽  
...  

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancer types worldwide, with the lowest 5-year survival rate among all kinds of cancers. Histopathology image analysis is considered a gold standard for PDAC detection and diagnosis. However, the manual diagnosis used in current clinical practice is a tedious and time-consuming task and diagnosis concordance can be low. With the development of digital imaging and machine learning, several scholars have proposed PDAC analysis approaches based on feature extraction methods that rely on field knowledge. However, feature-based classification methods are applicable only to a specific problem and lack versatility, so that the deep-learning method is becoming a vital alternative to feature extraction. This paper proposes the first deep convolutional neural network architecture for classifying and segmenting pancreatic histopathological images on a relatively large WSI dataset. Our automatic patch-level approach achieved 95.3% classification accuracy and the WSI-level approach achieved 100%. Additionally, we visualized the classification and segmentation outcomes of histopathological images to determine which areas of an image are more important for PDAC identification. Experimental results demonstrate that our proposed model can effectively diagnose PDAC using histopathological images, which illustrates the potential of this practical application.


2020 ◽  
Vol 139 ◽  
pp. 109696 ◽  
Author(s):  
Kaplan Kaplan ◽  
Yılmaz Kaya ◽  
Melih Kuncan ◽  
H. Metin Ertunç

2020 ◽  
Author(s):  
Tuan Pham

The importance of automated classification of histopathological images has been increasingly recognized for effective processing of large volumes of data in the era of digital pathology for new discovery of disease mechanism. This paper presents a deep-learning approach that extracts time-frequency features of H&E stained tissue images for classification by long short-term memory networks. Using two large public databases of colorectal-cancer and heart-failure H&E stained tissue images, the proposed approach outperforms several state-of-the-art benchmark classification methods, including support vector machines and convolutional neural networks in terms of several statistical measures.


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