scholarly journals Point-of-Care Diagnostic Services as an Integral Part of Health Services during the Novel Coronavirus 2019 Era

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 449
Author(s):  
Tivani P. Mashamba-Thompson ◽  
Paul K. Drain
Keyword(s):  
Health Services ◽  
Mobile Technology ◽  
Point Of Care ◽  
Holistic Approach ◽  
The Novel ◽  
Pathology Laboratory ◽  
Laboratory Services ◽  
Point Of Care Diagnostics ◽  
Private And Public ◽  
Novel Coronavirus

Point-of-care (POC) diagnostic services are commonly associated with pathology laboratory services. This issue presents a holistic approach to POC diagnostics services from a variety of disciplines including pathology, radiological and information technology as well as mobile technology and artificial intelligence. This highlights the need for transdisciplinary collaboration to ensure the efficient development and implementation of point-of-care diagnostics. The advent of the novel coronavirus 2019 (COVID-19) pandemic has prompted rapid advances in the development of new POC diagnostics. Global private and public sector agencies have significantly increased their investment in the development of POC diagnostics. There is no longer a question about the availability and accessibility of POC diagnostics. The question is “how can POC diagnostic services be integrated into health services in way that is useful and acceptable in the COVID-19 era?”.

scholarly journals Pocket MUSE: an affordable, versatile and high-performance fluorescence microscope using a smartphone

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Yehe Liu ◽  
Andrew M. Rollins ◽  
Richard M. Levenson ◽  
Farzad Fereidouni ◽  
Michael W. Jenkins
Keyword(s):  
High Performance ◽  
Point Of Care ◽  
Low Cost ◽  
Consumer Electronics ◽  
Practical Implementation ◽  
The Novel ◽  
Point Of Care Diagnostics ◽  
Optical Module ◽  
Optical Configuration ◽  
User Friendly

AbstractSmartphone microscopes can be useful tools for a broad range of imaging applications. This manuscript demonstrates the first practical implementation of Microscopy with Ultraviolet Surface Excitation (MUSE) in a compact smartphone microscope called Pocket MUSE, resulting in a remarkably effective design. Fabricated with parts from consumer electronics that are readily available at low cost, the small optical module attaches directly over the rear lens in a smartphone. It enables high-quality multichannel fluorescence microscopy with submicron resolution over a 10× equivalent field of view. In addition to the novel optical configuration, Pocket MUSE is compatible with a series of simple, portable, and user-friendly sample preparation strategies that can be directly implemented for various microscopy applications for point-of-care diagnostics, at-home health monitoring, plant biology, STEM education, environmental studies, etc.

scholarly journals Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2

Viruses ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 582 ◽  
Author(s):  
Nadin Younes ◽  
Duaa W. Al-Sadeq ◽  
Hadeel AL-Jighefee ◽  
Salma Younes ◽  
Ola Al-Jamal ◽  
...  
Keyword(s):  
Point Of Care ◽  
Accurate Determination ◽  
High Sensitivity ◽  
Laboratory Diagnosis ◽  
The Novel ◽  
Viral Shedding ◽  
Diagnostic Capacity ◽  
Commercial Kits ◽  
Novel Coronavirus ◽  
Diagnostic Technologies

The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. The past three unprecedented outbreaks of emerging human coronavirus infections at the beginning of the 21st century have highlighted the importance of readily available, accurate, and rapid diagnostic technologies to contain emerging and re-emerging pandemics. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) based assays performed on respiratory specimens remain the gold standard for COVID-19 diagnostics. However, point-of-care technologies and serologic immunoassays are rapidly emerging with high sensitivity and specificity as well. Even though excellent techniques are available for the diagnosis of symptomatic patients with COVID-19 in well-equipped laboratories; critical gaps still remain in screening asymptomatic people who are in the incubation phase of the virus, as well as in the accurate determination of live viral shedding during convalescence to inform decisions for ending isolation. This review article aims to discuss the currently available laboratory methods and surveillance technologies available for the detection of COVID-19, their performance characteristics and highlight the gaps in current diagnostic capacity, and finally, propose potential solutions. We also summarize the specifications of the majority of the available commercial kits (PCR, EIA, and POC) for laboratory diagnosis of COVID-19.

scholarly journals ANALISIS LAMA WAKTU PELAYANAN LABORATORIUM DI RUMAH SAKIT UMUM DAERAH PASAMAN BARAT

2018 ◽  
Vol 5 (1) ◽  
pp. 114-121
Author(s):  
Betti Rosita ◽  
Ulfa Khairani
Keyword(s):  
Health Services ◽  
Waiting Time ◽  
Service Time ◽  
Clinical Chemistry ◽  
Clinical Pathology ◽  
Blood Chemistry ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Laboratory Service ◽  
Laboratory Services

Hospital laboratory services is one of the activities in hospitals that support quality health services. One indicator of the success of health services in the field of clinical pathology laboratory services is the waiting time for laboratory services. The standard set for laboratory service outcome waiting time is ≤ 140 minutes for blood chemistry and routine blood. This research analyzed the service time of outpatient laboratory that conducted hematology and clinical chemistry examination in the laboratory of Pasaman Barat Hospital. This research is a type of descriptive analytic research that is quantitative and supported by qualitative using cross sectional approach. The result of the research showed that laboratory service time at RSUD Pasaman Barat fulfilled the standard (≤ 140 minutes) for hematology examination 33.94 minutes, clinical chemistry 83.92 minutes, hematology and clinical chemistry 98 minutes. Based on the results of this study, the stages that contribute to the length of time laboratory services for hematological examination lies in the pre analytical stage, for clinical chemistry examination is located at the analytical stage, as well as for hematology and clinical chemistry examination lies in the analytic stage as well as the factors that affect the length of time laboratory services are human resources that is in the ability of officers and infrastructure facilities

scholarly journals Clinical Progress Note: Point-of-Care Ultrasound Applications in COVID-19

2020 ◽  
Vol 15 (6) ◽  
pp. 353-355 ◽  
Author(s):  
Benji K Mathews ◽  
Seth Koenig ◽  
Linda Kurian ◽  
Benjamin Galen ◽  
Gregory Mints ◽  
...  
Keyword(s):  
Septic Shock ◽  
Respiratory Failure ◽  
Critical Illness ◽  
Literature Search ◽  
Point Of Care ◽  
Severe Illness ◽  
Point Of Care Ultrasound ◽  
The Novel ◽  
Novel Coronavirus ◽  
Ultrasound Applications

COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, was declared a pandemic on March 11, 2020. Although most patients (81%) develop mild illness, 14% develop severe illness, and 5% develop critical illness, including acute respiratory failure, septic shock, and multiorgan dysfunction.1 Point-of-care ultrasound (POCUS), or bedside ultrasound performed by a clinician caring for the patient, is being used to support the diagnosis and serially monitor patients with COVID-19. We performed a literature search of electronically discoverable peer-reviewed publications on POCUS use in COVID-19 from December 1, 2019, to April 10, 2020. We review key POCUS applications that are most relevant to frontline providers in the care of COVID-19 patients.

scholarly journals 2019 Novel Coronavirus Disease (COVID-19): Paving the Road for Rapid Detection and Point-of-Care Diagnostics

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 306 ◽  
Author(s):  
Trieu Nguyen ◽  
Dang Duong Bang ◽  
Anders Wolff
Keyword(s):  
Rapid Detection ◽  
Point Of Care ◽  
Potential Candidate ◽  
The Road ◽  
Point Of Care Diagnostics ◽  
Novel Coronavirus

We believe a point-of-care (PoC) device for the rapid detection of the 2019 novel Coronavirus (SARS-CoV-2) is crucial and urgently needed. With this perspective, we give suggestions regarding a potential candidate for the rapid detection of the coronavirus disease 2019 (COVID-19), as well as factors for the preparedness and response to the outbreak of the COVID-19.

scholarly journals Medical Tourism Markets: Models of Sustainability. The Case of Spain and The Costa del Sol (Malaga)

2020 ◽  
Vol 12 (21) ◽  
pp. 8818
Author(s):  
Ricardo Pagan ◽  
Daniel Horsfall
Keyword(s):  
Health Services ◽  
Medical Tourism ◽  
Tourism Industry ◽  
Data Availability ◽  
The Novel ◽  
Health Providers ◽  
Domestic Industry ◽  
Competitive Prices ◽  
Novel Coronavirus ◽  
Near Future

The interest and relevance of medical tourism has increased significantly over the last few decades, and it has become a very lucrative source of income and profit for many firms. This paper analyses the sustainability of the medical tourism model in Spain in general, and in The Costa del Sol (Spain) in particular, in order to investigate the potential challenges that the domestic industry will face in the future. For this purpose, we first analysed the process of the globalization of health services and the main characteristics of the Spanish medical tourism industry (in terms of tourism and health services). Second, we examined the data availability on medical tourism for the cases of Spain, Andalusia and The Costa del Sol, and identified who travels, why, and for what reasons. The results show that Spain and The Costa del Sol offer high-quality medical and tourism facilities and services with very competitive prices, and with the high commitment and support of public local authorities, tourism and health providers, and universities. However, the lack of a real leadership, well-defined strategy, financial support, and specific training programs are considered to be crucial challenges for the near future. In addition to this, the novel coronavirus, the economic crisis, Brexit and the situation of British expats living in Spain and The Costa del sol are also discussed.

A Rapid and Quantitative Serum Test for SARS-CoV-2 Antibodies with Portable Surface Plasmon Resonance Sensing

2020 ◽  
Author(s):  
Abdelhadi Djaileb ◽  
Benjamin Charron ◽  
Maryam Hojjat Jodaylami ◽  
Vincent Thibault ◽  
Julien Coutu ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Human Serum ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Point Of Care ◽  
The Novel ◽  
Label Free ◽  
Spr Sensor ◽  
Novel Coronavirus ◽  
Nanomolar Range

We report a surface plasmon resonance (SPR) sensor detecting nucleocapsid antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in undiluted human serum. When exposed to SARS-CoV-2, the immune system responds by expressing antibodies at levels that can be detected and monitored to identify the patient population immunized against SARD-CoV-2 and support efforts to deploy a vaccine strategically. A SPR sensor coated with a peptide monolayer and functionalized with SARS-CoV-2 nucleocapsid recombinant protein detected anti-SARS-CoV-2 antibodies in the nanomolar range. This bioassay was performed on a portable SPR instrument in undiluted human serum and results were collected within 15 minutes of sample/sensor contact. This strategy paves the way to point-of-care and label-free rapid testing for antibodies.

A Rapid and Quantitative Serum Test for SARS-CoV-2 Antibodies with Portable Surface Plasmon Resonance Sensing

2020 ◽  
Author(s):  
Abdelhadi Djaileb ◽  
Benjamin Charron ◽  
Maryam Hojjat Jodaylami ◽  
Vincent Thibault ◽  
Julien Coutu ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Human Serum ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Point Of Care ◽  
The Novel ◽  
Label Free ◽  
Spr Sensor ◽  
Novel Coronavirus ◽  
Nanomolar Range

We report a surface plasmon resonance (SPR) sensor detecting nucleocapsid antibodies specific against the novel coronavirus 2019 (SARS-CoV-2) in undiluted human serum. When exposed to SARS-CoV-2, the immune system responds by expressing antibodies at levels that can be detected and monitored to identify the patient population immunized against SARD-CoV-2 and support efforts to deploy a vaccine strategically. A SPR sensor coated with a peptide monolayer and functionalized with SARS-CoV-2 nucleocapsid recombinant protein detected anti-SARS-CoV-2 antibodies in the nanomolar range. This bioassay was performed on a portable SPR instrument in undiluted human serum and results were collected within 15 minutes of sample/sensor contact. This strategy paves the way to point-of-care and label-free rapid testing for antibodies.

scholarly journals The SARS-COV-2 Spike Protein Binds Sialic Acids, and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device

2020 ◽  
Author(s):  
Alexander N. Baker ◽  
Sarah-Jane Richards ◽  
Collette S. Guy ◽  
Thomas R. Congdon ◽  
Muhammad Hasan ◽  
...  
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lateral Flow ◽  
Function Optimization ◽  
Spike Protein ◽  
Spike Glycoprotein ◽  
Binding Function ◽  
Point Of Care Diagnostics ◽  
Novel Coronavirus ◽  
Flow Detection

<div> <div> <div> <p>There is an urgent need to understand the behavior of novel coronavirus (SARS-COV-2), which is the causative agent of COVID-19, and to develop point-of-care diagnostics. Here, a glyconanoparticle platform is used to discover that N-acetyl neuraminic acid has high affinity towards the SARS-COV-2 spike glycoprotein, demonstrating its glycan-binding function. Optimization of the particle size and coating enabled detection of the spike glycoprotein in lateral flow and showed selectivity over the SARS-COV-1 spike protein. Using a viral particle mimic, paper-based lateral flow detection was demonstrated in under 30 minutes showing the potential of this system as a low-cost detection platform. </p> </div> </div> </div>

scholarly journals Current and emerging diagnostic tests available for the novel COVID-19 global pandemic

2020 ◽  
Vol 3 ◽  
pp. 8 ◽  
Author(s):  
Gerald Mboowa
Keyword(s):  
Diagnostic Tests ◽  
Point Of Care ◽  
World Health ◽  
The Novel ◽  
Global Pandemic ◽  
The Us ◽  
The Status ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Point Of Care Tests

On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests have been developed at an astonishing pace; however, COVID-19 requires more highly specific rapid point-of-care diagnostic tests. This review describes the currently available testing approaches, as well as the available test assays including the Xpert® Xpress SARS-CoV-2 test (takes ~45 min) and Abbott ID COVID-19 test (5 min) as easy to use point-of-care tests for diagnosis of novel COVID-19 that have so far received the US Food and Drug Administration emergency use authorizations clearance. This review is correct as of the date published and will be updated as more diagnostic tests come to light.

Sign in / Sign up

Export Citation Format

Share Document