scholarly journals Solvent-Mediated Polymorphic Transformation of Famoxadone from Form II to Form I in Several Mixed Solvent Systems

Crystals ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 161 ◽  
Author(s):  
Dan Du ◽  
Guo-Bin Ren ◽  
Ming-Hui Qi ◽  
Zhong Li ◽  
Xiao-Yong Xu
Keyword(s):  
Polymorphic Transformation ◽  
Growth Process ◽  
Mixed Solvent ◽  
Transformation Process ◽  
Stable Form ◽  
Transformation Rate ◽  
Metastable Form ◽  
Dipolar Polarizability ◽  
Solvent Systems ◽  
Polymorph Screening

This paper discloses six polymorphs of famoxadone obtained from polymorph screening, which were characterized by XRPD, DSC, and SEM. A study of solvent-mediated polymorphic transformation (SMPT) of famoxadone from the metastable Form II to the stable Form I in several mixed solvent systems at the temperature of 30 °C was also conducted. The transformation process was monitored by Process Analytical Technologies. It was confirmed that the Form II to Form I polymorphic transformation is controlled by the Form I growth process. The transformation rate constants depended linearly on the solubility difference value between Form I and Form II. Furthermore, the hydrogen-bond-donation/acceptance ability and dipolar polarizability also had an effect on the rate of solvent-mediated polymorphic transformation.

scholarly journals Natural product mixture analysis by matrix-assisted DOSY using Brij surfactants in mixed solvents

RSC Advances ◽  
2014 ◽  
Vol 4 (79) ◽  
pp. 42029-42034 ◽  
Author(s):  
Mariano G. S. Vieira ◽  
Nilce V. Gramosa ◽  
Nágila M. P. S. Ricardo ◽  
Gareth A. Morris ◽  
Ralph W. Adams ◽  
...  
Keyword(s):  
Natural Product ◽  
Mixed Solvent ◽  
Mixed Solvents ◽  
Mixture Analysis ◽  
Surfactant Micelles ◽  
Product Mixture ◽  
Solvent Systems ◽  
Nmr Signals

Brij surfactant micelles in mixed solvent systems aid resolution of natural product NMR signals in diffusion-ordered spectroscopy.

scholarly journals A review on conductometric studies of electrolytes in mixed solvent systems to understand ion-ion and ion-solvent interactions

2020 ◽  
Vol 10 (3) ◽  
pp. 5355-5360
Keyword(s):  
Mixed Solvent ◽  
Mixed Solvents ◽  
Chemical Properties ◽  
Electrolyte Solutions ◽  
Molar Conductance ◽  
Extensive Literature ◽  
Solvent Interactions ◽  
Physico Chemical ◽  
Wide Range ◽  
Solvent Systems

The study of ion- solvent interaction is of much importance to investigate the nature of different solutions. Measurement of electrical conductivity and evaluation of physico-chemical properties, such as molar conductance, limiting molar conductance, ion-pair association, Walden product etc. shade light on different intermolecular interactions present in electrolyte solutions. Solvation properties can be varied by mixing two or more solvents. An extensive literature survey on conductometric studies has been carried out on different electrolytes dissolved in a wide range of mixed solvent systems. The reported results show that strong solute-solute, solute-solvent and solvent-solvent interactions are responsible for the physico- chemical behavior of a solution in mixed solvents.

Excess molar volumes of N,N-dimethylformamide+2-pentanone+alkan-1-ols mixed solvent systems at 303.15K

2006 ◽  
Vol 443 (1) ◽  
pp. 62-71 ◽  
Author(s):  
P. Venkatesu ◽  
G. Chandra Sekhar ◽  
M.V. Prabhakara Rao ◽  
Tadeusz Hofman
Keyword(s):  
Mixed Solvent ◽  
Excess Molar Volumes ◽  
Molar Volumes ◽  
Solvent Systems
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