scholarly journals Quasi-Continuous Production and Separation of Lysozyme Crystals on an Integrated Laboratory Plant

Crystals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 713
Author(s):  
Timo Dobler ◽  
Benjamin Radel ◽  
Marco Gleiss ◽  
Hermann Nirschl
Keyword(s):  
Continuous Production ◽  
Temperature Sensitive ◽  
Process Chain ◽  
Single Plant ◽  
Multistage Process ◽  
Filter Cloth ◽  
Solid Liquid ◽  
Solid Liquid Separation ◽  
Lysozyme Crystals ◽  
Complete Process

Vacuum crystallization with subsequent solid–liquid separation is a suitable method to produce and separate the temperature-sensitive protein lysozyme. The conventional process is performed batch-wise and on different devices, which in turn leads to disadvantages in terms of energy efficiency, contamination risk and process control. This publication therefore focuses on the application of the previously multistage process to a quasi-continuous, integrated single plant. The transfer occurs successively and starts with the substitution of the batch vessel by a process chamber. Afterwards, the filtration scale is increased and the formerly deployed membrane is replaced by an industrial filter cloth. Based on the results of these experiments, the complete process chain is successfully transferred to an integrated laboratory plant.

scholarly journals Development and Commissioning of a Small-Scale, Modular and Integrated Plant for the Quasi-Continuous Production of Crystalline Particles

Processes ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 663
Author(s):  
Timo Dobler ◽  
Simon Buchheiser ◽  
Marco Gleiß ◽  
Hermann Nirschl
Keyword(s):  
Modular Design ◽  
Continuous Production ◽  
Small Scale ◽  
Distribution Width ◽  
Pharmaceutical Industries ◽  
The Individual ◽  
Almost All ◽  
Solid Liquid ◽  
Solid Liquid Separation ◽  
High Degree

Increasing global competition, volatile markets and the demand for individual products challenge companies in almost all business sectors and require innovative solutions. In the chemical and pharmaceutical industries, these include modular design, the integration of several unit operations in one apparatus and the development of small-scale, versatile multipurpose plants. An example for such a modular, integrated and small-scale system is the belt crystallizer. This device combines the process steps cooling crystallization, solid-liquid separation and contact drying in a single plant. The basis of the apparatus is a belt filter in which the vacuum trays below the filter medium are replaced by temperature control and filtration units. Due to identical dimensions, it is possible to arrange the individual functional units in any order, which in turn allows a high degree of flexibility and rapid adaptation to customer requirements. Within the scope of the publication, the commissioning of the belt crystallizer takes place. First of all, the general functionality of the plant concept is demonstrated using sucrose as model system. Further experiments show that the particle size and the distribution width of the manufactured crystals can be specifically influenced by the selected process parameters, e.g., temperature profile during cooling and residence time.

scholarly journals Combination of Natural and Thermosensitive Polymers in Flocculation of Fine Silica Dispersions

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Angel Licea-Claverie ◽  
Simona Schwarz ◽  
Christine Steinbach ◽  
Sandra Montserrat Ponce-Vargas ◽  
Sabine Genest
Keyword(s):  
Sedimentation Velocity ◽  
Laser Diffraction ◽  
Temperature Sensitive ◽  
Thermosensitive Polymer ◽  
Separation Processes ◽  
Thermosensitive Polymers ◽  
Novel Strategy ◽  
Solid Liquid ◽  
Solid Liquid Separation ◽  
Sensitive Behavior

A novel strategy for faster and better flocculation in solid-liquid separation processes is reported: the use of the natural polyelectrolyte chitosan (CH2500) in combination with the biocompatible thermosensitive polymer poly(N-vinylcaprolactam) (PNVCL). Silica dispersions (Aerosil OX50) were used as model and evaluated by means of analytical centrifuge, laser diffraction, and turbidimetry studies. Results show that the sedimentation velocity is doubled by addition of PNVCL and that at 45°C the density of the sediment is 33% higher, as compared to the use of CH2500 only. This results from the temperature sensitive behavior of PNVCL that phase-separate expelling water at temperatures higher than its LCST (32–34°C) leading to compaction of the flocs. By using this strategy the sediment is more compact, contains less water, and contains a very small amount of biodegradable CH2500 and biocompatible PNVCL.

Nitrogen Removal in a Real-Time Controlled Sequencing Batch Membrane Bioreactor

2010 ◽  
Vol 5 (3) ◽  
Author(s):  
Cheng-Nan Chang ◽  
Li-Ling Lee ◽  
Han-Hsien Huang ◽  
Ying-Chih Chiu
Keyword(s):  
Real Time ◽  
Nitrogen Removal ◽  
Membrane Bioreactor ◽  
Synthetic Wastewater ◽  
Real Time Control ◽  
Time Control ◽  
Cake Layer ◽  
On Line ◽  
Solid Liquid ◽  
Solid Liquid Separation

The performance of a real-time controlled Sequencing Batch Membrane Bioreactor (SBMBR) for removing organic matter and nitrogen from synthetic wastewater has been investigated in this study under two specific ammonia loadings of 0.0086 and 0.0045g NH4+-N gVSS−1 day−1. Laboratory results indicate that both COD and DOC removal are greater than 97.5% (w/w) but the major benefit of using membrane for solid-liquid separation is that the effluent can be decanted through the membrane while aeration is continued during the draw stage. With a continued aeration, the sludge cake layer is prevented from forming thus alleviating the membrane clogging problem in addition to significant nitrification activities observed in the draw stage. With adequate aeration in the oxic stage, the nitrogen removal efficiency exceeding 99% can be achieved with the SBMBR system. Furthermore, the SBMBR system has also been used to study the occurrence of ammonia valley and nitrate knee that can be used for real-time control of the biological process. Under appropriate ammonia loading rates, applicable ammonia valley and nitrate knee are detected. The real-time control of the SBMBR can be performed based on on-line ORP and pH measurements.

Investigations on the filtration of natural aquatic suspensions supported by dosing small amounts of Fe(III)-salts (βFe ≤ 0.1 mg.L-1): mode of action and basic design criteria

2002 ◽  
Vol 2 (2) ◽  
pp. 91-98
Author(s):  
R. Winzenbacher ◽  
R. Schick ◽  
H.-H. Stabel ◽  
M. Jekel
Keyword(s):  
Large Scale ◽  
Suspended Solids ◽  
Iron Hydroxides ◽  
Essential Step ◽  
Iron Salts ◽  
Alkaline Earths ◽  
Co Precipitation ◽  
Solid Liquid ◽  
Solid Liquid Separation

Improved removal of particles during the treatment of natural aquatic suspensions has been achieved by pre-ozonation and the addition of small quantities of iron salts (βFe ≤ 0.1 mg.L-1; “Fe(III)-assisted filtration”) followed by rapid filtration. As shown by investigations on a large-scale installation at Lake Constance Water Supply, this procedure reliably reduces suspended solids by at least 2-3 powers of ten in long-term use. However, the high efficacy of Fe(III)-assisted filtration cannot be explained on the basis of known coagulation mechanisms (like adsorption-charge neutralization, co-precipitation). Instead, the essential step was found to be the conditioning of the filter medium by coating it with colloids containing Fe(OH)3, and this “Fe coating” process occurs only in the presence of alkaline earths (especially Ca2+). According to further experiments, the enhanced solid-liquid separation was ultimately traced to chemical interactions such as the formation of calcium-organic association structures between the iron hydroxides and other solids. For design of Fe(III)-assisted filtration steps, finally, a βCa/DOC ratio above 40 mg.mg-1 and pre-oxidation with ozone dosages not exceeding 2 mg O3/mg DOC was recommended.

scholarly journals Fundamental Study of Palladium Recycling Using “Dry Aqua Regia” Considering the Recovery from Spent Auto-catalyst

2021 ◽  
Author(s):  
Akihiro Yoshimura ◽  
Shunta Tochigi ◽  
Yasunari Matsuno
Keyword(s):  
Potassium Chloride ◽  
Platinum Group Metals ◽  
Recycling Process ◽  
Fundamental Study ◽  
Aqua Regia ◽  
Sodium Chloride Solutions ◽  
Pure Compounds ◽  
The Difference ◽  
Solid Liquid ◽  
Solid Liquid Separation

AbstractIn this research, a recycling process for palladium using “dry aqua regia,” which consists of iron(III) chloride–potassium chloride, was proposed. Palladium was dissolved in “dry aqua regia,” and the dissolved palladium was recovered by leaching with potassium chloride solution with added ammonium chloride and nitric acid. Palladium was almost completely dissolved in 3 h at 600 K, and the recovery ratio of dissolved palladium was up to 80%. In addition, the dissolution of palladium in coexistence with platinum and the dissolution of platinum-palladium alloy by “dry aqua regia” were also tested. The dissolved palladium and platinum were separated and recovered by solid–liquid separation technique using the difference in solubility of their compounds in potassium chloride and sodium chloride solutions. As a result, pure compounds of each element were recovered. This result suggested the possibility of using “dry aqua regia” for the separation of platinum-group metals. Graphical Abstract

Intensification of solid–liquid separation by thermal sedimentation in pressure oxidative leaching process of chromite

2021 ◽  
Vol 164 ◽  
pp. 106825
Author(s):  
Xiaoyu Tang ◽  
Shihao He ◽  
Facheng Qiu ◽  
Xianfeng Qin ◽  
Xuejun Quan ◽  
...  
Keyword(s):  
Liquid Separation ◽  
Leaching Process ◽  
Oxidative Leaching ◽  
Solid Liquid ◽  
Solid Liquid Separation

<i>Evaluation of Mechanical Scraper System Finishing Barn for Solid-Liquid Separation</i>

2017 ◽  
Author(s):  
Joshua Tyler Brown ◽  
Teng Teeh Lim ◽  
Joseph Zulovich ◽  
Christine Costello
Keyword(s):  
Liquid Separation ◽  
Solid Liquid ◽  
Solid Liquid Separation
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