scholarly journals Effect of Process Conditions on Particle Size and Shape in Continuous Antisolvent Crystallisation of Lovastatin

Crystals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 925
Author(s):  
John McGinty ◽  
Magdalene W. S. Chong ◽  
Andrew Manson ◽  
Cameron J. Brown ◽  
Alison Nordon ◽  
...  
Keyword(s):  
Particle Size ◽  
Flow Rate ◽  
Experimental Work ◽  
Downstream Processing ◽  
Process Conditions ◽  
Total Flow ◽  
Total Flow Rate ◽  
Size And Shape ◽  
Acetone Water ◽  
Particle Size And Shape

Lovastatin crystals often exhibit an undesirable needle-like morphology. Several studies have shown how a needle-like morphology can be modified in antisolvent crystallisation with the use of additives, but there is much less experimental work demonstrating crystal shape modification without the use of additives. In this study, a series of unseeded continuous antisolvent crystallisation experiments were conducted with the process conditions of supersaturation, total flow rate, and ultrasound level being varied to determine their effects on crystal size and shape. This experimental work involved identifying acetone/water as the most suitable solvent/antisolvent system, assessing lovastatin nucleation behaviour by means of induction time measurements, and then designing and implementing the continuous antisolvent crystallisation experiments. It was found that in order to produce the smallest and least needle-like particles, the maximum total flow rate and supersaturation had to be combined with the application of ultrasound. These results should aid development of pharmaceutical manufacturing processes where the ability to control particle size and shape would allow for optimisation of crystal isolation and more efficient downstream processing.

scholarly journals Effects of water salinity on the foam dynamics for EOR application

2021 ◽  
Author(s):  
Svetlana Rudyk ◽  
Sami Al-Khamisi ◽  
Yahya Al-Wahaibi
Keyword(s):  
Flow Rate ◽  
Liquid Flow ◽  
Apparent Viscosity ◽  
Liquid Flow Rate ◽  
Salinity Range ◽  
Porous System ◽  
Foam Formation ◽  
Total Flow ◽  
Total Flow Rate ◽  
Foam Flow

AbstractFactors limiting foam injection for EOR application are exceptionally low rock permeability and exceedingly high salinity of the formation water. In this regard, foam formation using internal olefin sulfonate is investigated over a wide salinity range (1, 5, 8, 10, and 12% NaCl) through 10 mD limestone. The relationships between pressure drop (dP), apparent viscosity, liquid flow rate, total flow rate, salinity, foam texture, and length of foam drops at the outlet used as an indicator of viscosity are studied. Foaming is observed up to 12% NaCl, compared to a maximum of 8% NaCl in similar core-flooding experiments with 50 mD limestone and 255 mD sandstone. Thus, the salinity limit of foam formation has increased significantly due to the low permeability, which can be explained by the fact that the narrow porous system acts like a membrane with smaller holes. Compared to the increasing dP reported for highly permeable rocks, dP linearly decreases in almost the entire range of gas fraction (fg) at 1–10% NaCl. As fg increases, dP at higher total flow rate is higher at all salinities, but the magnitude of dP controls the dependence of apparent viscosity on total flow rate. Low dP is measured at 1% and 10% NaCl, and high dP is measured at 5, 8, and 12% NaCl. In the case of low dP, the apparent viscosity is higher at higher total flow rate with increasing gas fraction, but similar at two total flow rates with increasing liquid flow rate. In the case of high dP, the apparent viscosity is higher at lower total flow rate, both with an increase in the gas fraction and with an increase in the liquid flow rate. A linear correlation is found between dP or apparent viscosity and liquid flow rate, which defines it as a governing factor of foam flow and can be considered when modeling foam flow.

EXTRACTION OF MINUTE GAS BUBBLES FROM LIQUIDS FLOWING IN A SIMULATED CARDIOPULMONARY BYPASS SYSTEM BY A VENTURI-ASPIRATOR UNIT

2002 ◽  
Vol 02 (03n04) ◽  
pp. 297-312
Author(s):  
WEN-JEI YANG ◽  
AMR EID ◽  
R. ECHIGO
Keyword(s):  
Cardiopulmonary Bypass ◽  
Flow Rate ◽  
Whole Blood ◽  
Pressure Difference ◽  
Gas Bubbles ◽  
Blood Oxygenation ◽  
Straight Tube ◽  
Suction Pressure ◽  
Total Flow ◽  
Total Flow Rate

An experimental study is performed to extract minute gas bubbles from liquids flowing in a simulated cardiopulmonary bypass system using a Venturi-aspirator unit. In other words, oxygen bubbles in oxygenated blood are simulated by air bubbles in water with AP30 (about same viscosity as whole blood). This study is intended to determine the feasibility of using a Venturi aspirator unit to extract minute gas bubbles from a simulated cardiopulmonary bypass system. Testing of the Venturi-type bubble extraction is carried out using three different test sections. Two Venturis are used, and a straight tube configuration is used as a control. The two Venturis are similar, with the exception that one has a longer inlet cone which causes the entering liquid to accelerate at a slower rate. Results are obtained for effectiveness of the aspirator unit as functions of total flow rate, extraction suction, suction pressure difference, and hydraulic head. It is concluded from the study that:(i) The effectiveness of the Venturis is typically between 90 and 100 percent. It increases with an increase in suction or suction pressure difference but decreases with an increase in total flow rate.(ii) The Venturi is most suitable for extraction of minute gas bubbles, especially for use with AP30 (whole blood), which yields substantially higher effectiveness than water.(iii) It is anticipated that a Venturi-aspirator unit can be superior to other bubble separation device as the cardiopulmonary bypass system for applications in extra corporeal blood oxygenation.

Brake Wear Particle Size and Shape Analysis of Non-Asbestos Organic (NAO) and Semi Metallic Brake Pad

2014 ◽  
Vol 71 (2) ◽  
Author(s):  
Hussain, S. ◽  
M.K Abdul Hamid ◽  
A.R Mat Lazim ◽  
A.R. Abu Bakar
Keyword(s):  
Particle Size ◽  
Wear Particle ◽  
Brake Disc ◽  
Wear Particles ◽  
Brake Pad ◽  
Brake Pads ◽  
Size And Shape ◽  
Brake Wear Particles ◽  
Brake Wear ◽  
Particle Size And Shape

Brake wear particles resulting from friction between the brake pad and disc are common in brake system. In this work brake wear particles were analyzed based on the size and shape to investigate the effects of speed and load applied to the generation of brake wear particles. Scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDX) was used to identify the size, shape and element compositions of these particles. Two types of brake pads were studied which are non-asbestos organic and semi metallic brake pads. Results showed that the size and shape of the particles generatedvary significantly depending on the applied brake load, and less significantly on brake disc speed. The wear particle becomes bigger with increasing applied brake pressure. The wear particle size varies from 300 nm to 600 µm, and contained elements such as carbon, oxygen, magnesium, aluminum, sulfur and iron.

scholarly journals Particle Morphology Analysis of Biomass Material Based on Improved Image Processing Method

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Zhaolin Lu ◽  
Xiaojuan Hu ◽  
Yao Lu
Keyword(s):  
Image Processing ◽  
Particle Size ◽  
Particle Morphology ◽  
Processing Method ◽  
Image Resolution ◽  
Ultrasonic Dispersion ◽  
Image Processing Method ◽  
Size And Shape ◽  
Nominal Size ◽  
Particle Size And Shape

Particle morphology, including size and shape, is an important factor that significantly influences the physical and chemical properties of biomass material. Based on image processing technology, a method was developed to process sample images, measure particle dimensions, and analyse the particle size and shape distributions of knife-milled wheat straw, which had been preclassified into five nominal size groups using mechanical sieving approach. Considering the great variation of particle size from micrometer to millimeter, the powders greater than 250 μm were photographed by a flatbed scanner without zoom function, and the others were photographed using a scanning electron microscopy (SEM) with high-image resolution. Actual imaging tests confirmed the excellent effect of backscattered electron (BSE) imaging mode of SEM. Particle aggregation is an important factor that affects the recognition accuracy of the image processing method. In sample preparation, the singulated arrangement and ultrasonic dispersion methods were used to separate powders into particles that were larger and smaller than the nominal size of 250 μm. In addition, an image segmentation algorithm based on particle geometrical information was proposed to recognise the finer clustered powders. Experimental results demonstrated that the improved image processing method was suitable to analyse the particle size and shape distributions of ground biomass materials and solve the size inconsistencies in sieving analysis.

Residual Stress in Bone: A Parametric Study

2008 ◽  
Author(s):  
A. Hizal ◽  
B. Sadasivam ◽  
D. Arola
Keyword(s):  
Residual Stress ◽  
Particle Size ◽  
Residual Stresses ◽  
Material Removal ◽  
Surface Deformation ◽  
Radius Of Curvature ◽  
Near Surface ◽  
Size And Shape ◽  
Air Jet ◽  
Particle Size And Shape

A preliminary study was conducted to evaluate the parametric dependence of the residual stress distributions in bone that result from an abrasive air-jet surface treatment. Specifically, the influence of particle size and shape used in the treatment on the residual stress, propensity of embedding particles and material removal were studied. Rectangular beams of cortical bone were prepared from bovine femurs and treated with aluminum oxide and glass particles with different treatment angles. Residual stresses within the bone were quantified in terms of the radius of curvature of the bone specimens measured before and after the treatments, as well as a function of time to quantify decay in the stress. The sub-surface distribution was also examined using the layer removal technique. Results showed that the particle size and shape could be used to control the amount of material removal and the magnitude of residual stress within the treated surfaces. An increase in size of the glass particles resulted in an increase in the residual stress and a decrease in material removed during the treatment. The magnitude of residual stress ranged from 22 MPa to nearly 44 MPa through modulation of the particle qualities (size and shape). A microscopic examination of the treated surfaces suggests that the residual stresses resulted primarily from near-surface deformation.

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