scholarly journals Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region

Computation ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
Anusmriti Ghosh ◽  
Mohammad S. Islam ◽  
Suvash C. Saha
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Particle Deposition ◽  
Magnetic Drug Targeting ◽  
Nano Particle ◽  
Specific Position ◽  
Targeted Drug ◽  
Lung Airways

Aerosolized drug inhalation plays an important role in the treatment of respiratory diseases. All of the published in silico, in vivo, and in vitro studies have improved the knowledge of aerosol delivery in the human respiratory system. However, aerosolized magnetic nano-particle (MNP) transport and deposition (TD) for the specific position of the human lung are still unavailable in the literature. Therefore, this study is aimed to provide an understanding of the magnetic nano-particle TD in the targeted region by imposing an external magnetic field for the development of future therapeutics. Uniform aerosolized nano-particle TD in the specific position of the lung airways will be modelled by adopting turbulence k–ω low Reynolds number simulation. The Euler–Lagrange (E–L) approach and the magneto hydrodynamics (MHD) model are incorporated in the ANSYS fluent (18.0) solver to investigate the targeted nano-particle TD. The human physical activity conditions of sleeping, resting, light activity and fast breathing are considered in this study. The aerosolized drug particles are navigated to the targeted position under the influence of external magnetic force (EMF), which is applied in two different positions of the two-generation lung airways. A numerical particle tracing model is also developed to predict the magnetic drug targeting behavior in the lung. The numerical results reveal that nano-particle deposition efficiency (DE) in two different magnetic field position is different for various physical activities, which could be helpful for targeted drug delivery to a specific region of the lung after extensive clinical trials. This process will also be cost-effective and will minimize unwanted side effects due to systemic drug distribution in the lung.

Computational Simulation of Magnetic Drug Targeting in Human Body

2011 ◽  
Author(s):  
Reza Kamali ◽  
Gholamreza Keshavarzi
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Human Body ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Computational Simulation ◽  
Magnetic Drug Targeting ◽  
Targeted Drug ◽  
Specific Part

Development of novel particle carrier methods has led to enhanced advances in targeted drug delivery. This paper has aimed the investigation of targeting drugs via attached magnetic particles into human body. This goal was approached by inducing a magnetic field near a specific part of the human body to target the drug or as it is called magnetic drug targeting (MDT). Blood flow and magnetic particles are simulated under the presence of the specified properties of a magnetic field. In order to demonstrate a more realistic simulation, the flow was considered pulsatile. Finally, the results provided show valuable information on magnetic drug targeting in human body.

scholarly journals Magnetic chitosan for drug targeting and in vitro drug delivery response

2011 ◽  
Vol 1 (5) ◽  
pp. 160-165 ◽  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Hybrid Materials ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Laser Scanning Microscopy ◽  
Magnetic Drug Targeting ◽  
Targeted Drug

The magnetic targeted drug delivery system is one of the most attractive strategies of delivering drugs to the area of interest. Magnetic drug targeting is based on using magnetic drug carrier particles to selectively deliver drugs to a specific site inside the body by using an external magnet field to attract and retain them there. Our study was focused to the synthesis, characterization and in vitro drug delivery response of magnetic hybrid material based Fe3O4/chitosan/cephalosporins (Cefepime, Ceftriaxone, Cefuroxime, Cefoperazone, Cefpirome, Cefaclor). Magnetic materials were characterized by CLSM (Confocal Laser Scanning Microscopy) and µATR-FT-IR (Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy). All these hybrid materials have been prepared in order to develop a magnetic drug delivery system and can be utilized to facilitate the targeted drug delivery of cephalosporins. The hybrid materials are obtained under mild conditions without any organic solvents and surfactants, which are more suitable for pharmaceutical applications.

Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations

2013 ◽  
Vol 5 (15) ◽  
pp. 6909-6914 ◽  
Author(s):  
Guodong Liu ◽  
He Shen ◽  
Jinning Mao ◽  
Liming Zhang ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

Corrigendum to: Establishment and In Vitro Evaluation of Porous Ion-Responsive Targeted Drug Delivery System. Protein & Peptide Letters, volume 27(11), (2020).

2021 ◽  
Vol 28 (3) ◽  
pp. 359-359
Author(s):  
Hongfei Liu ◽  
Jie Zhu ◽  
Pengyue Bao ◽  
Yueping Ding ◽  
Jiapeng Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Electronic Version ◽  
In Vitro Evaluation ◽  
Corrected Version ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The authors are regretful for submitting and approving the publication of incorrect Figure 4 in this article. Below is the corrected version along with the revised caption. The electronic version of the article has already been corrected.

Ultrasound-Mediated Targeted Drug Delivery Generated by Multifocal Beam Patterns: An In vitro Study

2013 ◽  
Vol 39 (3) ◽  
pp. 507-514 ◽  
Author(s):  
Dana Gourevich ◽  
Yoni Hertzberg ◽  
Alexander Volovick ◽  
Yaron Shafran ◽  
Gil Navon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Targeted Drug ◽  
Beam Patterns
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