Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations

2013 ◽  
Vol 5 (15) ◽  
pp. 6909-6914 ◽  
Author(s):  
Guodong Liu ◽  
He Shen ◽  
Jinning Mao ◽  
Liming Zhang ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

scholarly journals A Composite of Hyaluronic Acid-Modified Graphene Oxide and Iron Oxide Nanoparticles for Targeted Drug Delivery and Magnetothermal Therapy

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 9284-9293 ◽  
Author(s):  
Nilkamal Pramanik ◽  
Santhalakshmi Ranganathan ◽  
Sunaina Rao ◽  
Kaushik Suneet ◽  
Shilpee Jain ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Targeted Drug Delivery ◽  
Oxide Nanoparticles ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery

2017 ◽  
Vol 77 ◽  
pp. 904-911 ◽  
Author(s):  
Meng-Meng Song ◽  
Huai-Liang Xu ◽  
Jun-Xing Liang ◽  
Hui-Hui Xiang ◽  
Rui Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Iron Oxide ◽  
Targeted Drug Delivery ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene

Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations

2018 ◽  
Vol 295 ◽  
pp. 97-108 ◽  
Author(s):  
Sakine Shirvalilou ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Nida Jamali Raoufi ◽  
Mohammad Reza Karimi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Nano Graphene

scholarly journals Niosomes: A Novel Targeted Drug Delivery System

2021 ◽  
Author(s):  
Iman Akbarzadeh ◽  
Kamand Sedaghatnia ◽  
Mahsa Bourbour ◽  
Zahra Moghaddam ◽  
Maryam Moghtaderi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
In Silico ◽  
Metallic Nanoparticles ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Structure Characterization ◽  
Targeted Drug

Nanotechnology is making significant transformation to our world, especially in healthcare and the treatment of diseases. It is widely used in different medical applications, such as in treatment and detection. Targeting diseased cell with nanomedicines is one of the numerous applications of nanotechnology. Targeted drug delivery systems for delivering various types of drugs to specific sites are such a dynamic area in pharmaceutical biotechnology and nanotechnology. Compared to conventional drugs, nanomedicines have a higher absorption and bioavailability rate, improving efficacy and minimizing side effects. There are several drug delivery systems including metallic nanoparticles, polymers, liposomes, and microspheres, but one of the most important is the niosomes, which are produced by nonionic surfactants. Because of the amphiphilic nature and structure, hydrophilic or hydrophobic drugs can be loaded into niosome structures. Other compounds, including cholesterol, can also be applied to the niosomes' backbone to rigidize the structure. Several variables such as the type of surfactant in niosome production, the preparation method, and the hydration temperature can affect the structure of the niosomes. Nevertheless, in-silico design of drug delivery formulations requires molecular dynamic simulation tools, molecular docking, and ADME (absorption; distribution; excretion; metabolism) properties, which evaluate physicochemical features of formulation and ADME attitudes before synthesis, investigating the interaction between nano-carriers and specific targets. Hence, experimenting in-vitro and in-vivo is essential. In this review, the basic aspects of niosomes are described including their structure, characterization, preparation methods, optimization with in-silico tools, factors affecting their formation, and limitations.

scholarly journals Micro/Nanorobot: A Promising Targeted Drug Delivery System

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 665 ◽  
Author(s):  
Mengyi Hu ◽  
Xuemei Ge ◽  
Xuan Chen ◽  
Wenwei Mao ◽  
Xiuping Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electric Fields ◽  
Targeted Drug Delivery ◽  
Disease Diagnosis ◽  
Research Field ◽  
Traditional Drug ◽  
Targeted Drug ◽  
Autonomous Movement

Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots.

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