scholarly journals Risk Factors of Growth Retardation and Developmental Deficits in Very Preterm Infants in a German Tertiary Neonatal Unit

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 394
Author(s):  
Hanne Lademann ◽  
Anna Janning ◽  
Josephyn Müller ◽  
Luisa Neumann ◽  
Dirk Olbertz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Body Length ◽  
Cognitive Outcome ◽  
Individual Risk ◽  
Future Research ◽  
National Guidelines ◽  
Very Preterm Infants ◽  
Developmental Care ◽  
Developmental Index

Over the last two decades, improvements in perinatology have led to increased survival rates of preterm infants. A large number of studies and meta-analyses have investigated of preterm infants and/or the influence of developmental care. However, the combined influence of the most frequent risk factors and developmental care on the long-term somatic, motor, and cognitive outcome of preterm infants remains unclear. This retrospective, single-center cohort study includes 256 children treated in a tertiary neonatal intensive care unit in Rostock, Germany, between 2008 and 2013. Follow-up examinations (somatic, psychomotor, and mental development) were performed at (corrected) 24 months using Bayley Scales of Infant Development II (BSID-II). Developmental care was carried out according to the legal framework and national guidelines (physiotherapy and/or early education). Bronchopulmonary dysplasia (BPD) and an exclusive formula feeding showed a 2.8–4.6-fold higher risk (95% Confidence Interval: Mental Developmental Index 1.73–7.58; Psychomotor Developmental Index 1.44–14.54; body length 1.20–6.41) for developmental deficits (mental and psychomotor developmental index; body length). Developmental care after discharge according to national guidelines did not prevent this. Since this is a retrospective pilot study, no recommendations can be made based on this analysis. Therefore, future research should evaluate whether standard developmental care should be extended by tailored measures depending on individual risk factors.

scholarly journals Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

2017 ◽  
Vol 106 (3) ◽  
pp. 821-830 ◽  
Author(s):  
Jean-Christophe Rozé ◽  
Pierre-Yves Ancel ◽  
Patricia Lepage ◽  
Laetitia Martin-Marchand ◽  
Ziad Al Nabhani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gut Microbiota ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Microbiota Composition ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Nutritional Strategies ◽  
Gut Microbiota Composition

scholarly journals 49 NEUROLOGICAL IMPAIRMENT AT ONE YEAR PREDICTS NEUROLOGICAL AND COGNITIVE OUTCOME AT EIGHT YEARS IN VERY PRETERM INFANTS

1991 ◽  
Vol 30 (6) ◽  
pp. 636-636 ◽  
Author(s):  
S C Roth ◽  
J Baudin ◽  
J Townsend ◽  
D C McCormick ◽  
A D Edwards ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurological Impairment ◽  
Cognitive Outcome ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
One Year

Leading Causes of Preterm Delivery as Risk Factors for Intraventricular Hemorrhage in Very Preterm Infants

2018 ◽  
Vol 38 (1) ◽  
pp. 43-44
Author(s):  
M. Chevallier ◽  
T. Debillon ◽  
V. Pierrat ◽  
P. Delorme ◽  
G. Kayem ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Delivery ◽  
Preterm Infants ◽  
Intraventricular Hemorrhage ◽  
Very Preterm Infants ◽  
Very Preterm

Neurodevelopmental outcomes following preterm birth and the association with postmenstrual age at discharge

2022 ◽  
Author(s):  
Polly Kellner ◽  
Jenny Kwon ◽  
Joan Smith ◽  
Roberta G Pineda
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Ductus Arteriosus ◽  
Neurodevelopmental Outcome ◽  
Cognitive Outcome ◽  
Composite Score ◽  
Neurodevelopmental Outcomes ◽  
Medical Risk ◽  
Medical Risk Factors ◽  
Postmenstrual Age

Objective: To 1) define the prevalence of motor, cognitive, and language delays in preterm infants born < 32 weeks estimated gestational age (EGA) and 2) identify the relationship between the timing of discharge from the NICU and neurodevelopmental outcome in early childhood. Study Design: This retrospective study of 176 preterm infants born < 32 weeks EGA and hospitalized in a level IV NICU captured medical factors, including timing of discharge, from the NICU stay. Standardized developmental testing at 1-2 years corrected age was conducted in the newborn follow-up clinic. Results: At 1-2 years corrected age, the sample had an average cognitive composite score of 91.5 ± 17.4, language composite score of 84.5 ± 17.3, and motor composite score of 88.9 ± 18.4. Lower EGA at birth, necrotizing enterocolitis, patent ductus arteriosus, and oxygen requirement for > 28 days were independently associated with higher postmenstrual age (PMA) at NICU discharge. After controlling for known risk factors, higher PMA at discharge was associated with poorer cognitive outcome [p < 0.001, (-0.16, -0.07), β = -0.35], poorer language outcome [p = 0.049 (-0.10, 0.00), β = -0.15] and poorer motor outcome [p < 0.001, (-0.14, -0.05), β = -0.30]. Conclusion: Poorer cognitive, language, and motor outcomes were associated with longer hospitalization, even after controlling for medical risk factors known to be associated with poorer outcome. This provides further evidence for the potential role of the environment that may be impacting the developmental outcomes of infants hospitalized in the NICU.

scholarly journals Level of NICU Quality of Developmental Care and Neurobehavioral Performance in Very Preterm Infants

PEDIATRICS ◽  
2012 ◽  
Vol 129 (5) ◽  
pp. e1129-e1137 ◽  
Author(s):  
R. Montirosso ◽  
A. Del Prete ◽  
R. Bellu ◽  
E. Tronick ◽  
R. Borgatti ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurobehavioral Performance ◽  
Very Preterm Infants ◽  
Developmental Care ◽  
Very Preterm
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