scholarly journals Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer?

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1674
Author(s):  
Ann M. Bode ◽  
Eunmiri Roh

Solar ultraviolet (SUV) exposure is a major risk factor in the etiology of cutaneous squamous cell carcinoma (cSCC). People commonly use sunscreens to prevent SUV-induced skin damage and cancer. Nonetheless, the prevalence of cSCC continues to increase every year, suggesting that commercially available sunscreens might not be used appropriately or are not completely effective. In the current study, a solar simulated light (SSL)-induced cSCC mouse model was used to investigate the efficacy of eight commonly used FDA-approved sunscreen components against skin carcinogenesis. First, we tested FDA-approved sunscreen components for their ability to block UVA or UVB irradiation by using VITRO-SKIN (a model that mimics human skin properties), and then the efficacy of FDA-approved sunscreen components was investigated in an SSL-induced cSCC mouse model. Our results identified which FDA-approved sunscreen components or combinations are effective in preventing cSCC development. Not surprisingly, the results indicated that sunscreen combinations that block both UVA and UVB significantly suppressed the formation of cutaneous papillomas and cSCC development and decreased the activation of oncoproteins and the expression of COX-2, keratin 17, and EGFR in SSL-exposed SKH-1 (Crl:SKH1-Hrhr) hairless mouse skin. Notably, several sunscreen components that were individually purported to block both UVA and UVB were ineffective alone. At least one component had toxic effects that led to a high mortality rate in mice exposed to SSL. Our findings provide new insights into the development of the best sunscreen to prevent chronic SUV-induced cSCC development.

2019 ◽  
Vol 20 (6) ◽  
pp. 1435 ◽  
Author(s):  
Young Her ◽  
Bich-Na Shin ◽  
Yun Lee ◽  
Joon Park ◽  
Dae Kim ◽  
...  

In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. Oenanthe javanica is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an Oenanthe javanica extract (OJE) against UVB-induced skin damage in ICR mice. The extent of skin damage was evaluated in three groups: control mice with no UVB, UVB-exposed mice treated with vehicle (saline), and UVB-exposed mice treated with 1% extract. Photoprotective properties were assessed in the dorsal skin using hematoxylin and eosin staining, Masson trichrome staining, immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blotting to analyze the epidermal thickness, collagen expression, and mRNA and protein levels of type I collagen, type III collagen, and interstitial collagenases, including matrix metalloproteinase (MMP)-1 and MMP-3. In addition, tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 protein levels were also assessed. In the UVB-exposed mice treated with extract, UV-induced epidermal damage was significantly ameliorated. In this group, productions of collagen types I and III were increased, and expressions of MMP-1 and MMP-3 were decreased. In addition, TNF-α and COX-2 expressions were reduced. Based on these findings, we conclude that OJE displays photoprotective effects against UVB-induced collagen disruption and inflammation and suggest that Oenanthe javanica can be used as a natural product for the treatment of photodamaged skin.


Pathology ◽  
1986 ◽  
Vol 18 (3) ◽  
pp. 337-344 ◽  
Author(s):  
P.J. Canfield ◽  
G.E. Greenoak ◽  
V.E. Reeve ◽  
C.H. Gallagher ◽  
Fu-Nan Xu ◽  
...  

2017 ◽  
Author(s):  
Mee-Hyun Lee ◽  
Do Young Lim ◽  
Sung Young Lee ◽  
Jung Hyun Shim ◽  
Xuejiao Liu ◽  
...  

2008 ◽  
Vol 84 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Joydeb Kumar Kundu ◽  
Eun-Jin Chang ◽  
Hajime Fujii ◽  
Buxiang Sun ◽  
Young-Joon Surh

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e28065 ◽  
Author(s):  
Md. Mostafizur Rahman ◽  
Joydeb Kumar Kundu ◽  
Jun-Wan Shin ◽  
Hye-Kyung Na ◽  
Young-Joon Surh

Sign in / Sign up

Export Citation Format

Share Document